| MP:0000130 | abnormal cancellous bone morphology | "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Atp7aMo-brJ/Y
Genetic Background: involves: C3H/HeJ * C57BL/6J
|
| MP:0000135 | reduced cortical bone thickness | "thinner than normal superficial layer of compact bone " [J:61509] |
Show
Allelic Composition: Atp7aMo-brJ/Y
Genetic Background: involves: C3H/HeJ * C57BL/6J
|
| MP:0000136 | abnormal microglial cell morphology | "anomalous structure, number, or composition of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, J:71688] |
Show
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: 129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri/J
|
| MP:0000219 | increased neutrophil count | "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Atp7aMo-brJ/Y
Genetic Background: involves: C3H/HeJ * C57BL/6J
|
| MP:0000598 | abnormal liver morphology | "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170] |
Show
Allelic Composition: Camk2atm1Sva/Camk2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0000599 | enlarged liver | "larger than average size of the liver" [J:65146] |
Show
Allelic Composition: Atp7aMo-brJ/Y
Genetic Background: involves: C3H/HeJ * C57BL/6J
|
| MP:0000607 | abnormal hepatocyte morphology | "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Bard1tm1Thl/Bard1tm1Thl,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S1/Sv * 129S2/SvPas
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: involves: 129S7/SvEvBrd
|
| MP:0000691 | enlarged spleen | "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Atp7aMo-brJ/Y
Genetic Background: involves: C3H/HeJ * C57BL/6J
|
| MP:0000693 | spleen hyperplasia | "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401] |
Show
Allelic Composition: Atp7aMo-brJ/Y
Genetic Background: involves: C3H/HeJ * C57BL/6J
|
| MP:0001263 | weight loss | "progressive reduction of body weight below normal average for age" [J:45400] |
Show
Allelic Composition: Atp7aMo-brJ/Y
Genetic Background: involves: C3H/HeJ * C57BL/6J
|
| MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
Show
Allelic Composition: Atp7aMo-brJ/Y,Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6J
|
| MP:0001570 | abnormal circulating enzyme level | "aberrent concentration in the blood of any of the proteins that act as catalysts for biological reactions" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Camk2atm1Sva/Camk2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0001654 | hepatic necrosis | "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Bard1tm1Thl/Bard1tm1Thl,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S1/Sv * 129S2/SvPas
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: 129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: involves: 129S7/SvEvBrd
|
| MP:0001670 | abnormal mineral absorption | "anomalous ability of the body to take in any inorganic substance that has importance in body functions" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Tyrp1rgsc101/Tyrp1rgsc101
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl
|
| MP:0001759 | increased urine glucose level | "a greater level of excretion of glucose in the urine compared to the normal state" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Atp7aMo-brJ/Y
Genetic Background: involves: C3H/HeJ * C57BL/6J
|
| MP:0001765 | abnormal ion homeostasis | "anomaly in the state of equilibrium in the body with respect to charged molecules in the fluids and tissues" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Bard1tm1Thl/Bard1tm1Thl,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S1/Sv * 129S2/SvPas
|
| MP:0001792 | impaired wound healing | "reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: involves: 129S7/SvEvBrd
|
| MP:0001800 | abnormal humoral immune response | "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
Show
Allelic Composition: Atp7aMo-brJ/Y
Genetic Background: involves: C3H/HeJ * C57BL/6J
|
| MP:0001859 | kidney inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
Show
Allelic Composition: Atp7aMo-brJ/Y
Genetic Background: involves: C3H/HeJ * C57BL/6J
|
| MP:0001861 | lung inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
Show
Allelic Composition: Atp7aMo-brJ/Y
Genetic Background: involves: C3H/HeJ * C57BL/6J
|
| MP:0001914 | hemorrhage | "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: involves: 129S7/SvEvBrd
|
| MP:0001919 | abnormal reproductive system physiology | "anomaly in the function of the organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Atp7aMo-brJ/Y
Genetic Background: involves: C3H/HeJ * C57BL/6J
|
| MP:0001944 | abnormal pancreas morphology | "malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: involves: 129S7/SvEvBrd
|
| MP:0002020 | increased tumor incidence | "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193] |
Show
Allelic Composition: Bard1tm1Thl/Bard1tm1Thl,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S1/Sv * 129S2/SvPas
|
| MP:0002063 | abnormal learning/memory/conditioning | "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Atp7aMo-brJ/Y
Genetic Background: involves: C3H/HeJ * C57BL/6J
|
| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Camk2atm1Sva/Camk2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0002118 | abnormal lipid homeostasis | "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Bard1tm1Thl/Bard1tm1Thl,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S1/Sv * 129S2/SvPas
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: involves: 129S7/SvEvBrd
|
| MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: involves: 129S7/SvEvBrd
|
| MP:0002182 | abnormal astrocyte morphology | "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Atp7aMo-brJ/Y
Genetic Background: involves: C3H/HeJ * C57BL/6J
|
| MP:0002493 | increased IgG | "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Atp7aMo-brJ/Y
Genetic Background: involves: C3H/HeJ * C57BL/6J
|
| MP:0002494 | increased IgM | "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Atp7aMo-brJ/Y
Genetic Background: involves: C3H/HeJ * C57BL/6J
|
| MP:0002906 | susceptibility to pharmacologically induced seizures | "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504] |
Show
Allelic Composition: Atp7aMo-brJ/Y
Genetic Background: involves: C3H/HeJ * C57BL/6J
|
| MP:0002941 | increased circulating alanine transaminase level | "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Bard1tm1Thl/Bard1tm1Thl,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S1/Sv * 129S2/SvPas
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: involves: 129S7/SvEvBrd
|
| MP:0002968 | increased circulating alkaline phosphatase level | "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: 129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri
|
| MP:0003055 | abnormal epiphyseal plate morphology | "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003] |
Show
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: 129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri/J
|
| MP:0003068 | enlarged kidney | "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: 129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri/J
|
| MP:0003103 | liver degeneration | "deterioration of the liver due to injury or disease, often accompanied by loss of function" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91653] |
Show
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: 129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri
|
| MP:0003197 | kidney calcification | "pathologic deposition of calcium salts in the kidney" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission] |
Show
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: 129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri/J
|
| MP:0003203 | increased neuron apoptosis | "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission] |
Show
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: 129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri/J
|
| MP:0003215 | renal interstitial fibrosis | "formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission] |
Show
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: 129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri/J
|
| MP:0003354 | astrocytosis | "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: involves: 129S7/SvEvBrd
|
| MP:0003674 | oxidative stress | "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: involves: 129S7/SvEvBrd
|
| MP:0003691 | abnormal microglial cell function | "anomalous activity of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [hdene:Howard Dene , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: involves: 129S7/SvEvBrd
|
| MP:0003797 | abnormal compact bone morphology | "structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: 129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri/J
|
| MP:0003945 | abnormal lymphocyte physiology | "abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: 129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri/J
|
| MP:0003946 | renal necrosis | "pathological cell death in the kidney, usually due to irreversible damage" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: 129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri/J
|
| MP:0003996 | clonic seizures | "increased number or decreased threshold for the induction of a seizure characterized by unilateral or bilateral rhythmic jerking movements of the arms and legs caused by alternating contraction and relaxation of muscle" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: 129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri/J
|
| MP:0003997 | tonic-clonic seizures | "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: 129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri/J
|
| MP:0004001 | decreased hepatocyte proliferation | "reduced growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: 129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri/J
|
| MP:0004016 | decreased bone mass | "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: 129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri/J
|
| MP:0004153 | increased renal tubule apoptosis | "increase in the number of renal tubule cells undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: 129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri/J
|
| MP:0004499 | increased incidence of chemically-induced tumors | "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Bard1tm1Thl/Bard1tm1Thl,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S1/Sv * 129S2/SvPas
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: 129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri/J
|
| MP:0004799 | increased susceptibility to experimental autoimmune encephalomyelitis | "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: involves: 129S7/SvEvBrd
|
| MP:0004860 | dilated kidney collecting duct | "stretched or widened aperture of the luminal space of the collecting ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: 129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri/J
|
| MP:0004952 | increased spleen weight | "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: 129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri/J
|
| MP:0004970 | kidney atrophy | "wasting of the kidney due to injury or disease, resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: 129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri/J
|
| MP:0005013 | increased lymphocyte number | "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Atp7aMo-brJ/Y
Genetic Background: involves: C3H/HeJ * C57BL/6J
|
| MP:0005017 | decreased B cell number | "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Atp7aMo-brJ/Y
Genetic Background: involves: C3H/HeJ * C57BL/6J
|
| MP:0005018 | decreased T cell number | "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Atp7aMo-brJ/Y
Genetic Background: involves: C3H/HeJ * C57BL/6J
|
| MP:0005165 | increased susceptibility to injury | "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Atp7aMo-brJ/Y
Genetic Background: involves: C3H/HeJ * C57BL/6J
|
| MP:0005241 | abnormal retinal ganglion layer morphology | "anomalous structure of the innermost nuclear layer of the retina, which projects axons through the optic nerve to the brain " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Hip1tm1Tsr/Hip1+
Genetic Background: involves: 129X1/SvJ * C57BL/6
|
| MP:0005325 | abnormal glomerulus | "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: involves: 129S7/SvEvBrd
|
| MP:0005425 | increased macrophage count | "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418] |
Show
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: involves: 129S7/SvEvBrd
|
| MP:0005517 | decreased liver regeneration | "less than the normal ability of liver to regenerate healthy tissue following partial hepatectomy" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Atp7aMo-brJ/Y
Genetic Background: involves: C3H/HeJ * C57BL/6J
|
| MP:0005565 | increased blood urea nitrogen level | "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Atp7aMo-brJ/Y
Genetic Background: involves: C3H/HeJ * C57BL/6J
|
| MP:0006399 | abnormal long bone epiphyseal ossification zone morphology | "any anomaly in the structure of the layer of the epiphyseal plate where new bone matrix is deposited" [CALnet tutorial:http://137.222.110.150/calnet/Introanat/Introanat.htm, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: 129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri/J
|
| MP:0008074 | increased CD4-positive T cell number | "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: 129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri/J
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| MP:0008078 | increased CD8-positive T cell number | "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: 129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri/J
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| MP:0008097 | increased plasma cell number | "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: 129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri/J
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| MP:0008560 | increased tumor necrosis factor secretion | "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800] |
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Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0008657 | increased interleukin-1 beta secretion | "increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600] |
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Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0008705 | increased interleukin-6 secretion | "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506] |
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Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0008872 | abnormal response to xenobiotics | "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: 129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri/J
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| MP:0008873 | increased sensitivity to xenobiotics | "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bard1tm1Thl/Bard1tm1Thl,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S1/Sv * 129S2/SvPas
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: 129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri/J
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
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| MP:0008943 | increased sensitivity to induced cell death | "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Atp7aMo-brJ/Y,Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6J
Allelic Composition: Atp7aMo-brJ/Atp7a+,Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: involves: 129S7/SvEvBrd * C3H/HeJ
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| MP:0009050 | dilated proximal convoluted tubules | "stretched or widened aperture of the luminal space of the convoluted portion of the duct system of the nephron that extends from the renal glomerular capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: 129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri/J
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| MP:0009541 | increased thymocyte apoptosis | "increase in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: 129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri/J
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| MP:0009615 | abnormal zinc homeostasis | "anomaly in the processes involved in the maintenance of an internal equilibrium of zinc that normally is a cofactor in many proteins" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: 129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri/J
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: involves: 129S7/SvEvBrd * CD-1
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| MP:0009641 | kidney degeneration | "a retrogressive impairment of function or destruction of either or both of the two excretory organs that filter wastes (especially urea) from the blood and excrete them and water in urine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: 129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri/J
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| MP:0009766 | increased sensitivity to xenobiotic induced morbidity/mortality | "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bard1tm1Thl/Bard1tm1Thl,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S1/Sv * 129S2/SvPas
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: 129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri/J
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| MP:0010124 | decreased bone mineral content | "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: 129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri/J
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| MP:0011085 | complete postnatal lethality | "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Atp7aMo-brJ/Y,Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6J
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| MP:0011092 | complete embryonic lethality | "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith] |
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Allelic Composition: Atp7aMo-brJ/Atp7a+,Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: involves: 129S7/SvEvBrd * C3H/HeJ
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| MP:0011108 | partial embryonic lethality during organogenesis | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Atp7aMo-brJ/Y,Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6J
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| MP:0011501 | increased glomerular capsule space | "increased volume of the luminal region between the glomerular capsule visceral and parietal layers, into which filtrate enters after passing through the filtration barrier from the glomerular capillaries" [MGI:csmith] |
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Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0011924 | abnormal liver zinc level | "anomaly in the amount of zinc present in the liver tissue" [MPD:Molly] |
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Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0014178 | increased brain apoptosis | "increase in the number of cells of the brain undergoing programmed cell death" [MGI:Anna] |
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Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: involves: 129S7/SvEvBrd
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