ENSMUSG00000031780


Mus musculus

Features
Gene ID: ENSMUSG00000031780
  
Biological name :Ccl17
  
Synonyms : Ccl17 / chemokine (C-C motif) ligand 17
  
Possible biological names infered from orthology : C-C motif chemokine ligand 17 / Q92583
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: C5
Gene start: 94810453
Gene end: 94812036
  
Corresponding Affymetrix probe sets: 10574226 (MoGene1.0st)   1419413_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034232
NCBI entrez gene - 20295     See in Manteia.
MGI - MGI:1329039
RefSeq - XM_017312623
RefSeq - NM_011332
RefSeq - XM_006530782
RefSeq - XM_006530783
RefSeq Peptide - NP_035462
swissprot - F6R5P4
Ensembl - ENSMUSG00000031780
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CCL17ENSG00000102970Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000827  CC chemokine, conserved site
 IPR001811  Chemokine interleukin-8-like domain
 IPR036048  Chemokine interleukin-8-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002548 monocyte chemotaxis IBA
 biological_processGO:0006935 chemotaxis TAS
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0006968 cellular defense response TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IBA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030593 neutrophil chemotaxis IBA
 biological_processGO:0043547 positive regulation of GTPase activity IBA
 biological_processGO:0045662 negative regulation of myoblast differentiation IMP
 biological_processGO:0048247 lymphocyte chemotaxis IBA
 biological_processGO:0070098 chemokine-mediated signaling pathway IBA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IBA
 biological_processGO:0071346 cellular response to interferon-gamma IBA
 biological_processGO:0071347 cellular response to interleukin-1 IBA
 biological_processGO:0071356 cellular response to tumor necrosis factor IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005125 cytokine activity TAS
 molecular_functionGO:0008009 chemokine activity TAS
 molecular_functionGO:0048020 CCR chemokine receptor binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
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Allelic Composition: Kittm1(cre/ERT2)Dsa/Kit+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0004751 increased length of allograft survival "compared to controls, a greater length of time that transplanted tissue, in which the donor and recipient are genetically similar (same species) but not genetically identical, retains function and/or remains alive" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tubb3tm1.1Ece/Tubb3+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tubb3tm1.1Ece/Tubb3+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Kittm1(cre/ERT2)Dsa/Kit+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0008125 abnormal dendritic cell number "anomaly in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kittm1(cre/ERT2)Dsa/Kit+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0008556 abnormal tumor necrosis factor secretion "anomaly in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Kittm1(cre/ERT2)Dsa/Kit+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0008656 abnormal interleukin-1 beta secretion "anomaly in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
Show

Allelic Composition: Kittm1(cre/ERT2)Dsa/Kit+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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