ENSMUSG00000031897


Mus musculus

Features
Gene ID: ENSMUSG00000031897
  
Biological name :Psmb10
  
Synonyms : O35955 / Proteasome subunit beta type-10 / Psmb10
  
Possible biological names infered from orthology : AC040162.1 / P40306 / proteasome subunit beta 10
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: D3
Gene start: 105935735
Gene end: 105938444
  
Corresponding Affymetrix probe sets: 10581378 (MoGene1.0st)   1448632_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034369
NCBI entrez gene - 19171     See in Manteia.
MGI - MGI:1096380
RefSeq - XM_006530770
RefSeq - NM_013640
RefSeq - XM_006530769
RefSeq Peptide - NP_038668
swissprot - O35955
Ensembl - ENSMUSG00000031897
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 psmb10ENSDARG00000043781Danio rerio
 AC040162.1ENSG00000261884Homo sapiens
 P40306ENSG00000205220Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Psmb7 / P70195 / Proteasome subunit beta type-7 / Q99436* / proteasome subunit beta 7*ENSMUSG0000002675057


Protein motifs (from Interpro)
Interpro ID Name
 IPR000243  Peptidase T1A, proteasome beta-subunit
 IPR001353  Proteasome, subunit alpha/beta
 IPR016050  Proteasome beta-type subunit, conserved site
 IPR023333  Proteasome B-type subunit
 IPR024689  Proteasome beta subunit, C-terminal
 IPR029055  Nucleophile aminohydrolases, N-terminal
 IPR034384  Proteasome subunit beta type 10


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0042098 T cell proliferation IMP
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IEA
 cellular_componentGO:0000502 proteasome complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005839 proteasome core complex IDA
 cellular_componentGO:0019774 proteasome core complex, beta-subunit complex ISS
 cellular_componentGO:1990111 spermatoproteasome complex IDA
 molecular_functionGO:0004175 endopeptidase activity IEA
 molecular_functionGO:0004298 threonine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog on state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Ubiquitin-dependent degradation of Cyclin D1
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Interleukin-1 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Psmb10Tub6/Psmb10+
Genetic Background: C3HeB/FeJ-Psmb10Tub6

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Psmb10Tub6/Psmb10+
Genetic Background: C3HeB/FeJ-Psmb10Tub6

Allelic Composition: Psmb10Tub6/Psmb10Tub6
Genetic Background: B6.C3Fe-Psmb10Tub6

Allelic Composition: Psmb10Tub6/Psmb10Tub6
Genetic Background: C.C3Fe-Psmb10Tub6

Allelic Composition: Psmb10tm1Mgro/Psmb10Tub6
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
Show

Allelic Composition: Psmb10Tub6/Psmb10+
Genetic Background: C3HeB/FeJ-Psmb10Tub6

 MP:0000705 athymia "absence of the primary lymphoid organ" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Psmb10Tub6/Psmb10+
Genetic Background: C3HeB/FeJ-Psmb10Tub6

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
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Allelic Composition: Psmb10Tub6/Psmb10+
Genetic Background: C3HeB/FeJ-Psmb10Tub6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Psmb10Tub6/Psmb10+
Genetic Background: C3HeB/FeJ-Psmb10Tub6

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Bag3tm1b(EUCOMM)Hmgu/Bag3tm1b(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6N

 MP:0001836 abnormal antigen presentation via MHC class I "anomaly in the process by which peptide, bound to major histocompatibility complex class I, is presented to lymphocytes at the surface of antigen presenting cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Mir128-2)Ans/Gt(ROSA)26Sor+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: BALB/cJ * C57BL/6J * FVB/N

Allelic Composition: Psmb10tm1Mgro/Psmb10tm1Mgro,Psmb9/Psmb8tm1Klr/Psmb9/Psmb8tm1Klr
Genetic Background: B6.129-Psmb10tm1Mgro Psmb9/Psmb8tm1Klr

 MP:0001841 decreased level of surface class I molecule "reduced expression of major histocompatibility complex class I molecules at the cell surface " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm2(CAG-Mir128-2)Ans/Gt(ROSA)26Sor+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: BALB/cJ * C57BL/6J * FVB/N

Allelic Composition: Psmb10tm1Mgro/Psmb10tm1Mgro,Psmb9/Psmb8tm1Klr/Psmb9/Psmb8tm1Klr
Genetic Background: B6.129-Psmb10tm1Mgro Psmb9/Psmb8tm1Klr

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Psmb10Tub6/Psmb10+
Genetic Background: C3HeB/FeJ-Psmb10Tub6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Psmb10Tub6/Psmb10+
Genetic Background: C3HeB/FeJ-Psmb10Tub6

Allelic Composition: Psmb10tm1Mgro/Psmb10Tub6
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ

 MP:0002436 abnormal cytotoxic T cell morphology/development "anomalous structure, formation, or numbers of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pgm3Gt(W037B08)Wrst/Pgm3mld1
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002453 abnormal B lymphocyte antigen presentation "impairment in the ability of B lymphocyte to process and/or present antigen " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Mir128-2)Ans/Gt(ROSA)26Sor+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: BALB/cJ * C57BL/6J * FVB/N

Allelic Composition: Psmb10tm1Mgro/Psmb10tm1Mgro,Psmb9/Psmb8tm1Klr/Psmb9/Psmb8tm1Klr
Genetic Background: B6.129-Psmb10tm1Mgro Psmb9/Psmb8tm1Klr

 MP:0002455 abnormal dendritic cell antigen presentation "impairment of these specialized cells to process and present antigen to T lymphoytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Mir128-2)Ans/Gt(ROSA)26Sor+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: BALB/cJ * C57BL/6J * FVB/N

Allelic Composition: Psmb10tm1Mgro/Psmb10tm1Mgro,Psmb9/Psmb8tm1Klr/Psmb9/Psmb8tm1Klr
Genetic Background: B6.129-Psmb10tm1Mgro Psmb9/Psmb8tm1Klr

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Psmb10Tub6/Psmb10+
Genetic Background: C3HeB/FeJ-Psmb10Tub6

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Psmb10Tub6/Psmb10Tub6
Genetic Background: C3HeB/FeJ-Psmb10Tub6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Psmb10Tub6/Psmb10+
Genetic Background: C3HeB/FeJ-Psmb10Tub6

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bag3tm1b(EUCOMM)Hmgu/Bag3tm1b(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6N

Allelic Composition: Psmb10Tub6/Psmb10Tub6
Genetic Background: C3HeB/FeJ-Psmb10Tub6

Allelic Composition: Psmb10tm1Mgro/Psmb10Tub6
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ

 MP:0005046 failure of spleen white pulp formation "lack of development of the lymphoid area of the spleen" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
Show

Allelic Composition: Psmb10Tub6/Psmb10Tub6
Genetic Background: C3HeB/FeJ-Psmb10Tub6

 MP:0005078 abnormal cytotoxic T cell physiology "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pgm3Gt(W037B08)Wrst/Pgm3mld1
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Pgm3Gt(W037B08)Wrst/Pgm3mld1
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008024 absent lymph nodes "absence of the oval or bean shaped bodies located along the lymphatic system that consist of densely packed lymphocytes, lymph fluid and connective tissue; these are the sites where acquired immune responses are launched" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Psmb10Tub6/Psmb10Tub6
Genetic Background: C3HeB/FeJ-Psmb10Tub6

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Psmb10Tub6/Psmb10Tub6
Genetic Background: C3HeB/FeJ-Psmb10Tub6

Allelic Composition: Psmb10tm1Mgro/Psmb10Tub6
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bag3tm1b(EUCOMM)Hmgu/Bag3tm1b(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6N

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pgm3Gt(W037B08)Wrst/Pgm3mld1
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Psmb10tm1Mgro/Psmb10tm1Mgro,Psmb9/Psmb8tm1Klr/Psmb9/Psmb8tm1Klr
Genetic Background: B6.129-Psmb10tm1Mgro Psmb9/Psmb8tm1Klr

Allelic Composition: Psmb10Tub6/Psmb10+
Genetic Background: C3HeB/FeJ-Psmb10Tub6

 MP:0008477 decreased spleen red pulp amount "reduction in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Psmb10Tub6/Psmb10Tub6
Genetic Background: C3HeB/FeJ-Psmb10Tub6

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Psmb10Tub6/Psmb10Tub6
Genetic Background: C3HeB/FeJ-Psmb10Tub6

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Psmb10Tub6/Psmb10+
Genetic Background: C3HeB/FeJ-Psmb10Tub6

 MP:0008591 increased circulating interleukin-1 level "increase in the amount in the blood of a soluble factor produced by monocytes, macrophages and other cells, which activates T-lymphocytes and potentiates their response to mitogens or antigens" [MESH:D12.644.276.374.465.501]
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Allelic Composition: Psmb10Tub6/Psmb10Tub6
Genetic Background: C3HeB/FeJ-Psmb10Tub6

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Psmb10Tub6/Psmb10Tub6
Genetic Background: C3HeB/FeJ-Psmb10Tub6

 MP:0008843 absent subcutaneous adipose tissue "absence of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Psmb10Tub6/Psmb10Tub6
Genetic Background: C3HeB/FeJ-Psmb10Tub6

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Psmb10Tub6/Psmb10+
Genetic Background: C3HeB/FeJ-Psmb10Tub6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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