ENSMUSG00000031959


Mus musculus

Features
Gene ID: ENSMUSG00000031959
  
Biological name :Wdr59
  
Synonyms : Q8C0M0 / Wdr59 / WD repeat domain 59
  
Possible biological names infered from orthology : Q6PJI9
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: E1
Gene start: 111448797
Gene end: 111522092
  
Corresponding Affymetrix probe sets: 10581835 (MoGene1.0st)   1456638_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000148397
Ensembl peptide - ENSMUSP00000034437
Ensembl peptide - ENSMUSP00000043671
NCBI entrez gene - 319481     See in Manteia.
MGI - MGI:2442115
RefSeq - XM_011248402
RefSeq - NM_001170742
RefSeq - NM_001170743
RefSeq - NM_176923
RefSeq - XM_006531082
RefSeq - XM_006531083
RefSeq Peptide - NP_001164214
RefSeq Peptide - NP_795897
RefSeq Peptide - NP_001164213
swissprot - D3Z1F9
swissprot - Q8C0M0
swissprot - A0A1D5RLJ8
Ensembl - ENSMUSG00000031959
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wdr59ENSDARG00000088817Danio rerio
 WDR59ENSGALG00000002798Gallus gallus
 WDR59ENSG00000103091Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Wdr24 / Q8CFJ9 / WD repeat domain 24 / Q96S15*ENSMUSG0000002573714


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR006575  RWD domain
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016135  Ubiquitin-conjugating enzyme/RWD-like
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR036322  WD40-repeat-containing domain superfamily
 IPR037591  GATOR complex protein WDR59


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0032008 positive regulation of TOR signaling IEA
 biological_processGO:0034198 cellular response to amino acid starvation IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0061700 GATOR2 complex IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
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Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0013294 prenatal lethality prior to heart atrial septation "death prior to the completion of heart atrial septation (Mus: E14.5-15.5)" [MGI:smb]
Show

Allelic Composition: Usp3tm1b(EUCOMM)Wtsi/Usp3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Usp3tm1b(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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