ENSMUSG00000031982


Mus musculus

Features
Gene ID: ENSMUSG00000031982
  
Biological name :Arv1
  
Synonyms : Arv1 / Protein ARV1 / Q9D0U9
  
Possible biological names infered from orthology : ARV1 homolog, fatty acid homeostasis modulator / Q9H2C2
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: E2
Gene start: 124722139
Gene end: 124734123
  
Corresponding Affymetrix probe sets: 10576482 (MoGene1.0st)   1429161_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000148475
Ensembl peptide - ENSMUSP00000034463
Ensembl peptide - ENSMUSP00000148335
NCBI entrez gene - 68865     See in Manteia.
MGI - MGI:1916115
RefSeq - XM_011248496
RefSeq - NM_026855
RefSeq - XM_006531337
RefSeq - XM_006531338
RefSeq Peptide - NP_081131
swissprot - Q0VBH5
swissprot - Q9D0U9
swissprot - A0A1D5RLR4
swissprot - A0A1D5RLE6
Ensembl - ENSMUSG00000031982
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arv1ENSDARG00000074757Danio rerio
 ARV1ENSGALG00000011155Gallus gallus
 ARV1ENSG00000173409Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007290  Arv1 protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006665 sphingolipid metabolic process IBA
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0008206 bile acid metabolic process IMP
 biological_processGO:0030301 cholesterol transport ISO
 biological_processGO:0032366 intracellular sterol transport IBA
 biological_processGO:0032383 regulation of intracellular cholesterol transport ISS
 biological_processGO:0090181 regulation of cholesterol metabolic process IEA
 biological_processGO:0097036 regulation of plasma membrane sterol distribution IBA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane ISO
 cellular_componentGO:0005794 Golgi apparatus IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032541 cortical endoplasmic reticulum IBA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
Cholesterol biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trim25tm1Mura/Trim25+,Usp15L749R/Usp15+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Trim25tm1Mura/Trim25+,Usp15L749R/Usp15+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Trim25tm1Mura/Trim25+,Usp15L749R/Usp15+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

 MP:0001633 poor circulation "insufficient movement of blood throughout the body" [MGI:cls, J:45302]
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Allelic Composition: Trim25tm1Mura/Trim25+,Usp15L749R/Usp15+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trim25tm1Mura/Trim25+,Usp15L749R/Usp15+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Trim25tm1Mura/Trim25+,Usp15L749R/Usp15+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trim25tm1Mura/Trim25+,Usp15L749R/Usp15+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

 MP:0003949 abnormal circulating lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Trim25tm1Mura/Trim25+,Usp15L749R/Usp15+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Trim25tm1Mura/Trim25+,Usp15L749R/Usp15+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

 MP:0004892 increased adiponectin level "greater level of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trim25tm1Mura/Trim25+,Usp15L749R/Usp15+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trim25tm1Mura/Trim25+,Usp15L749R/Usp15+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Trim25tm1Mura/Trim25+,Usp15L749R/Usp15+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Trim25tm1Mura/Trim25+,Usp15L749R/Usp15+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trim25tm1Mura/Trim25+,Usp15L749R/Usp15+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Trim25tm1Mura/Trim25+,Usp15L749R/Usp15+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trim25tm1Mura/Trim25+,Usp15L749R/Usp15+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Trim25tm1Mura/Trim25+,Usp15L749R/Usp15+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trim25tm1Mura/Trim25+,Usp15L749R/Usp15+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

 MP:0008963 increased carbon dioxide production "increase in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trim25tm1Mura/Trim25+,Usp15L749R/Usp15+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

 MP:0008965 increased basal metabolism "increase in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [MESH:E01.370.374.750.100]
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Allelic Composition: Trim25tm1Mura/Trim25+,Usp15L749R/Usp15+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

 MP:0009133 decreased white fat cell size "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trim25tm1Mura/Trim25+,Usp15L749R/Usp15+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trim25tm1Mura/Trim25+,Usp15L749R/Usp15+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Trim25tm1Mura/Trim25+,Usp15L749R/Usp15+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

 MP:0013139 moribund "in terminal decline and approaching death; lacking vitality or vigor and becoming unresponsive" [MGI:Ahmad_Retha]
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Allelic Composition: Trim25tm1Mura/Trim25+,Usp15L749R/Usp15+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

 MP:0013245 abnormal lipid metabolism "any anomaly in the chemical reactions and pathways involving a lipid, including metabolic, catabolic and biosynthetic processes" [MPD:Molly]
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Allelic Composition: Trim25tm1Mura/Trim25+,Usp15L749R/Usp15+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

 MP:0013278 decreased fasted circulating glucose level "reduction in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
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Allelic Composition: Trim25tm1Mura/Trim25+,Usp15L749R/Usp15+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

 MP:0014143 decreased body fat mass "decreased physical bulk or volume of fat in the whole body" [MGI:csmith]
Show

Allelic Composition: Trim25tm1Mura/Trim25+,Usp15L749R/Usp15+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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