ENSMUSG00000032040


Mus musculus

Features
Gene ID: ENSMUSG00000032040
  
Biological name :Dcps
  
Synonyms : Dcps / m7GpppX diphosphatase / Q9DAR7
  
Possible biological names infered from orthology : decapping enzyme, scavenger / Q96C86
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A4
Gene start: 35124408
Gene end: 35176061
  
Corresponding Affymetrix probe sets: 10592099 (MoGene1.0st)   1424080_at (Mouse Genome 430 2.0 Array)   1446979_at (Mouse Genome 430 2.0 Array)   1456571_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121041
Ensembl peptide - ENSMUSP00000034539
Ensembl peptide - ENSMUSP00000113284
NCBI entrez gene - 69305     See in Manteia.
MGI - MGI:1916555
RefSeq - NM_027030
RefSeq Peptide - NP_081306
swissprot - D6RFQ0
swissprot - Q3TBW9
swissprot - Q9DAR7
Ensembl - ENSMUSG00000032040
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dcpsENSDARG00000009862Danio rerio
 DCPSENSGALG00000031143Gallus gallus
 DCPSENSG00000110063Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR008594  Scavenger mRNA decapping enzyme DcpS/DCS2
 IPR011145  Scavenger mRNA decapping enzyme, N-terminal
 IPR019808  Histidine triad, conserved site
 IPR036265  HIT-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0036245 cellular response to menadione IEA
 biological_processGO:0043069 negative regulation of programmed cell death IEA
 biological_processGO:0045292 mRNA cis splicing, via spliceosome IEA
 cellular_componentGO:0000932 P-body IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000340 RNA 7-methylguanosine cap binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0050072 m7G(5")pppN diphosphatase activity IEA


Pathways (from Reactome)
Pathway description
mRNA decay by 3 to 5 exoribonuclease


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Bay

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Bay

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Bay

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Bbs7tm1b(EUCOMM)Wtsi/Bbs7tm1b(EUCOMM)Wtsi
Genetic Background: B6N(Cg)-Bbs7tm1b(EUCOMM)Wtsi/J

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Bbs7tm1b(EUCOMM)Wtsi/Bbs7tm1b(EUCOMM)Wtsi
Genetic Background: B6N(Cg)-Bbs7tm1b(EUCOMM)Wtsi/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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