ENSMUSG00000032053


Mus musculus

Features
Gene ID: ENSMUSG00000032053
  
Biological name :Pou2af1
  
Synonyms : Pou2af1 / POU domain, class 2, associating factor 1 / Q64693
  
Possible biological names infered from orthology : POU class 2 associating factor 1 / Q16633
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A5.3
Gene start: 51213708
Gene end: 51240080
  
Corresponding Affymetrix probe sets: 10585276 (MoGene1.0st)   1416957_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000149529
Ensembl peptide - ENSMUSP00000034554
NCBI entrez gene - 18985     See in Manteia.
MGI - MGI:105086
RefSeq - NM_011136
RefSeq Peptide - NP_035266
swissprot - A0A1L1SRM5
swissprot - Q542H4
swissprot - Q64693
Ensembl - ENSMUSG00000032053
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CT573342.2ENSDARG00000104312Danio rerio
 POU2AF1ENSGALG00000006809Gallus gallus
 Q16633ENSG00000110777Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR015389  POU, class 2, associating factor 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IEA
 molecular_functionGO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Prkdctm1Gcl/Prkdctm1Gcl
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Map3k7tm1.1Mds/Map3k7tm1.1Mds
Genetic Background: Not Specified

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: Pou2af1tm1Pmt/Pou2af1tm1Pmt,Ikzf3tm1Kge/Ikzf3tm1Kge
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Pou2af1tm1Rgr/Pou2af1tm1Rgr
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv)

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

Allelic Composition: Pou2af1tm1Rgr/Pou2af1tm1Rgr
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv)

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pou2af1tm1Pmt/Pou2af1tm1Pmt,Ikzf3tm1Kge/Ikzf3tm1Kge
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

Allelic Composition: Pou2af1tm1Rgr/Pou2af1tm1Rgr
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv)

Allelic Composition: Pou2af1tm1Pjln/Pou2af1tm1Pjln
Genetic Background: C57BL/6-Pou2af1tm1Pjln

 MP:0001844 autoimmune response "condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Faslpr/Faslpr,Pou2af1tm1Pmt/Pou2af1tm1Pmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * MRL

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Map3k7tm1.1Mds/Map3k7tm1.1Mds
Genetic Background: Not Specified

Allelic Composition: Pou2af1tm1Pjln/Pou2af1tm1Pjln
Genetic Background: involves: C57BL/6

 MP:0002391 abnormal Peyer s patch germinal center morphology "anomalous structure or differentiation of the area of the Peyer s patch where B cells proliferate and differentiate into plasma cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Pou2af1tm1Rgr/Pou2af1tm1Rgr
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv)

 MP:0002403 abnormal pre-B cell "anomalous structure, development, or number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Pou2af1tm1Rgr/Pou2af1tm1Rgr
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv)

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

Allelic Composition: Pou2af1tm1Rgr/Pou2af1tm1Rgr
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv)

Allelic Composition: Faslpr/Faslpr,Pou2af1tm1Pmt/Pou2af1tm1Pmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * MRL

Allelic Composition: Pou2af1tm1Pmt/Pou2af1tm1Pmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pou2af1tm1Pjln/Pou2af1tm1Pjln,Tg(tetO-Pou2af1)1Pjln/0,Tg(tTA)1Pjln/0
Genetic Background: involves: C57BL/6

 MP:0002491 decreased IgD "less than normal immunoglobulin class D level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)

Allelic Composition: Pou2af1tm1Rgr/Pou2af1tm1Rgr
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv)

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pou2af1tm1Rgr/Pou2af1tm1Rgr
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv)

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Pou2af1tm1Pmt/Pou2af1tm1Pmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * MRL

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pou2af1tm1Rgr/Pou2af1tm1Rgr
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv)

Allelic Composition: Pou2af1tm1Pjln/Pou2af1tm1Pjln
Genetic Background: C57BL/6-Pou2af1tm1Pjln

Allelic Composition: Pou2af1tm1Pjln/Pou2af1tm1Pjln
Genetic Background: involves: C57BL/6

Allelic Composition: Pou2af1tm1Pjln/Pou2af1tm1Pjln,Tg(tetO-Pou2af1)1Pjln/0,Tg(tTA)1Pjln/0
Genetic Background: involves: C57BL/6

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pou2af1tm1Pjln/Pou2af1tm1Pjln
Genetic Background: involves: C57BL/6

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pou2af1tm1Pjln/Pou2af1tm1Pjln
Genetic Background: involves: C57BL/6

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pou2af1tm1Rgr/Pou2af1tm1Rgr
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv)

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pou2af1tm1Rgr/Pou2af1tm1Rgr
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv)

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Pou2af1tm1Pmt/Pou2af1tm1Pmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * MRL

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Pou2af1tm1Pjln/Pou2af1tm1Pjln
Genetic Background: involves: C57BL/6

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pou2af1tm1Pjln/Pou2af1tm1Pjln
Genetic Background: involves: C57BL/6

 MP:0006387 abnormal T cell number "deviation from the normal count of T cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Pou2af1tm1Pmt/Pou2af1tm1Pmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * MRL

 MP:0008098 decreased plasma cell number "reduced number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Pou2af1tm1Pmt/Pou2af1tm1Pmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * MRL

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Pou2af1tm1Pjln/Pou2af1tm1Pjln
Genetic Background: involves: C57BL/6

Allelic Composition: Pou2af1tm1Pjln/Pou2af1tm1Pjln,Tg(tetO-Pou2af1)1Pjln/0,Tg(tTA)1Pjln/0
Genetic Background: involves: C57BL/6

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pou2af1tm1Pjln/Pou2af1tm1Pjln
Genetic Background: involves: C57BL/6

 MP:0008474 absent spleen germinal center "absence of the area of the spleen secondary B follicle where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Pou2af1tm1Pmt/Pou2af1tm1Pmt,Ikzf3tm1Kge/Ikzf3tm1Kge
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Pou2af1tm1Rgr/Pou2af1tm1Rgr
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv)

Allelic Composition: Pou2af1tm1Pjln/Pou2af1tm1Pjln
Genetic Background: C57BL/6-Pou2af1tm1Pjln

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Pou2af1tm1Rgr/Pou2af1tm1Rgr
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv)

Allelic Composition: Pou2af1tm1Pjln/Pou2af1tm1Pjln
Genetic Background: C57BL/6-Pou2af1tm1Pjln

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Pou2af1tm1Rgr/Pou2af1tm1Rgr
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv)

Allelic Composition: Pou2af1tm1Pjln/Pou2af1tm1Pjln
Genetic Background: C57BL/6-Pou2af1tm1Pjln

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Pou2af1tm1Rgr/Pou2af1tm1Rgr
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv)

Allelic Composition: Pou2af1tm1Pjln/Pou2af1tm1Pjln
Genetic Background: C57BL/6-Pou2af1tm1Pjln

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Pou2af1tm1Rgr/Pou2af1tm1Rgr
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv)

Allelic Composition: Pou2af1tm1Pjln/Pou2af1tm1Pjln
Genetic Background: C57BL/6-Pou2af1tm1Pjln

 MP:0008523 absent lymph node germinal center "absence of the area of the lymph node secondary follicle where B cells are stimulated by antigens and helper T cells are stimulated to generate memory cells" [MESH:A10.549.400.500, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pou2af1tm1Rgr/Pou2af1tm1Rgr
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv)

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Pou2af1tm1Pjln/Pou2af1tm1Pjln
Genetic Background: involves: C57BL/6

 MP:0008672 increased interleukin-13 secretion "increase in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
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Allelic Composition: Pou2af1tm1Pjln/Pou2af1tm1Pjln
Genetic Background: involves: C57BL/6

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Pou2af1tm1Pjln/Pou2af1tm1Pjln
Genetic Background: involves: C57BL/6

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Pou2af1tm1Pjln/Pou2af1tm1Pjln
Genetic Background: involves: C57BL/6

 MP:0008782 increased B cell apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pou2af1tm1Pjln/Pou2af1tm1Pjln
Genetic Background: involves: C57BL/6

 MP:0011294 renal glomerulus hypertrophy "increase in the bulk size of the capillary loops of the kidney that normally function as a filtration unit, due to cell enlargement" [MGI:anna]
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Allelic Composition: Faslpr/Faslpr,Pou2af1tm1Pmt/Pou2af1tm1Pmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * MRL

 MP:0011506 glomerular crescent "formation of a crescent-shaped (semi-lunar) glomerular lesion corresponding to extracapillary proliferation of Bowman s capsular epithelium and acquiring a fibroblast-like spindled morphology, possibly stimulated by release of fibrinogen from a ruptured glomerular basement membrane; epithelial crescents occur in aggressive forms of glomerulonephritis, may be accompanied by collagen and fibrin deposition and/or monocyte and macrophage proliferation, may protrude into Bowman s space, and ultimately compress and destroy the glomerular tuft" [MGI:anna]
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Allelic Composition: Faslpr/Faslpr,Pou2af1tm1Pmt/Pou2af1tm1Pmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * MRL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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