ENSMUSG00000032114


Mus musculus

Features
Gene ID: ENSMUSG00000032114
  
Biological name :Slc37a4
  
Synonyms : glucose-6-phosphate exchanger SLC37A4 isoform a / Slc37a4
  
Possible biological names infered from orthology : solute carrier family 37 member 4
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A5.2
Gene start: 44396852
Gene end: 44402968
  
Corresponding Affymetrix probe sets: 10584741 (MoGene1.0st)   1417042_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000150843
Ensembl peptide - ENSMUSP00000150753
Ensembl peptide - ENSMUSP00000150902
Ensembl peptide - ENSMUSP00000151004
Ensembl peptide - ENSMUSP00000129564
Ensembl peptide - ENSMUSP00000148956
NCBI entrez gene - 14385     See in Manteia.
MGI - MGI:1316650
RefSeq - XM_006510016
RefSeq - NM_001293630
RefSeq - NM_001293631
RefSeq - NM_008063
RefSeq - XM_006510010
RefSeq - XM_006510011
RefSeq - XM_006510012
RefSeq - XM_006510013
RefSeq Peptide - NP_001280560
RefSeq Peptide - NP_001344659
RefSeq Peptide - NP_032089
RefSeq Peptide - NP_001280559
RefSeq Peptide - NP_001344658
swissprot - Q9D1F9
swissprot - A0A1L1SV42
swissprot - A0A1L1SUV7
swissprot - A0A1L1SUI3
Ensembl - ENSMUSG00000032114
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc37a4aENSDARG00000038106Danio rerio
 slc37a4bENSDARG00000093531Danio rerio
 slc37a4bENSDARG00000077180Danio rerio
 SLC37A4ENSGALG00000007716Gallus gallus
 SLC37A4ENSG00000137700Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000849  Sugar phosphate transporter
 IPR011701  Major facilitator superfamily
 IPR020846  Major facilitator superfamily domain
 IPR021159  Glycerate/sugar phosphate transporter, conserved site
 IPR027378  Cyclic nucleotide-regulated ion channel, N-terminal
 IPR036259  MFS transporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001780 neutrophil homeostasis IMP
 biological_processGO:0001816 cytokine production IMP
 biological_processGO:0002318 myeloid progenitor cell differentiation IMP
 biological_processGO:0005977 glycogen metabolic process IMP
 biological_processGO:0006089 lactate metabolic process IMP
 biological_processGO:0006641 triglyceride metabolic process IMP
 biological_processGO:0006874 cellular calcium ion homeostasis IMP
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0008202 steroid metabolic process IMP
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0015760 glucose-6-phosphate transport ISO
 biological_processGO:0030593 neutrophil chemotaxis IMP
 biological_processGO:0032682 negative regulation of chemokine production IMP
 biological_processGO:0035166 post-embryonic hemopoiesis IMP
 biological_processGO:0035435 phosphate ion transmembrane transport ISO
 biological_processGO:0042593 glucose homeostasis ISO
 biological_processGO:0042632 cholesterol homeostasis IMP
 biological_processGO:0043085 positive regulation of catalytic activity IMP
 biological_processGO:0045730 respiratory burst IMP
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane ISO
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0015152 glucose-6-phosphate transmembrane transporter activity ISO
 molecular_functionGO:0022857 transmembrane transporter activity IEA
 molecular_functionGO:0061513 glucose 6-phosphate:inorganic phosphate antiporter activity ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000065 abnormal bone marrow cavities "absence or abnormal size or shape of the medullary cavities of the bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

 MP:0000131 abnormal long bone epiphysis morphology "the head of a developing long bone that is separated from the shaft by the epiphyseal plate" [J:61509]
Show

Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

 MP:0000133 abnormal long bone metaphysis morphology "malformed conical section of bone between the epiphysis and diaphysis of the long bones" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
Show

Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

 MP:0001548 hyperlipidemia "abnormally high concentration of lipids in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

 MP:0001764 abnormal homeostasis "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

 MP:0003068 enlarged kidney "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
Show

Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

 MP:0005046 failure of spleen white pulp formation "lack of development of the lymphoid area of the spleen" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
Show

Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

 MP:0005440 increased glycogen level "greater than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

 MP:0006396 decreased long bone epiphyseal plate size "reduced size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

 MP:0008720 impaired neutrophil migration "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
Show

Allelic Composition: Card11tm1Pngr/Card11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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