ENSMUSG00000032221


Mus musculus

Features
Gene ID: ENSMUSG00000032221
  
Biological name :Mns1
  
Synonyms : Meiosis-specific nuclear structural protein 1 / Mns1 / Q61884
  
Possible biological names infered from orthology : meiosis specific nuclear structural 1 / Q8NEH6
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: D
Gene start: 72438011
Gene end: 72462025
  
Corresponding Affymetrix probe sets: 10586907 (MoGene1.0st)   1419402_at (Mouse Genome 430 2.0 Array)   1444769_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034746
Ensembl peptide - ENSMUSP00000139105
Ensembl peptide - ENSMUSP00000139232
NCBI entrez gene - 17427     See in Manteia.
MGI - MGI:107933
RefSeq - XM_011242665
RefSeq - NM_008613
RefSeq - XM_006510824
RefSeq Peptide - NP_032639
swissprot - V9GXE0
swissprot - V9GXM7
swissprot - Q61884
Ensembl - ENSMUSG00000032221
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mns1ENSDARG00000060169Danio rerio
 MNS1ENSGALG00000013893Gallus gallus
 MNS1ENSG00000138587Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR026504  Meiosis-specific nuclear structural protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0044782 cilium organization IMP
 biological_processGO:0045724 positive regulation of cilium assembly IMP
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:0070986 left/right axis specification IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope IDA
 cellular_componentGO:0005882 intermediate filament IDA
 cellular_componentGO:0005930 axoneme IDA
 cellular_componentGO:0036126 sperm flagellum IDA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Gli3tm1.1Zllr/Gli3tm1.2Zllr,Hoxa13tm1.1(cre)Makm/Hoxa13+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Gli3tm1.1Zllr/Gli3tm1.2Zllr,Hoxa13tm1.1(cre)Makm/Hoxa13+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gli3tm1.1Zllr/Gli3tm1.2Zllr,Hoxa13tm1.1(cre)Makm/Hoxa13+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gli3tm1.1Zllr/Gli3tm1.2Zllr,Hoxa13tm1.1(cre)Makm/Hoxa13+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Gli3tm1.1Zllr/Gli3tm1.2Zllr,Hoxa13tm1.1(cre)Makm/Hoxa13+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003178 left pulmonary isomerism "bilaterally symmetric left lung pattern (or altered asymmetric patterning of the lung)" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93051]
Show

Allelic Composition: Gli3tm1.1Zllr/Gli3tm1.2Zllr,Hoxa13tm1.1(cre)Makm/Hoxa13+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gli3tm1.1Zllr/Gli3tm1.2Zllr,Hoxa13tm1.1(cre)Makm/Hoxa13+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gli3tm1.1Zllr/Gli3tm1.2Zllr,Hoxa13tm1.1(cre)Makm/Hoxa13+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008892 abnormal sperm flagellum "any strucutral anomaly of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MESH:A05.360.490.890.840]
Show

Allelic Composition: Gli3tm1.1Zllr/Gli3tm1.2Zllr,Hoxa13tm1.1(cre)Makm/Hoxa13+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009237 kinked sperm flagellum "a sharp bend or zigzag in the sperm tail" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gli3tm1.1Zllr/Gli3tm1.2Zllr,Hoxa13tm1.1(cre)Makm/Hoxa13+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009239 short sperm flagellum "decreased length of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gli3tm1.1Zllr/Gli3tm1.2Zllr,Hoxa13tm1.1(cre)Makm/Hoxa13+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009832 abnormal sperm mitochondrial sheath morphology "any structural anomaly or impairment of the tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum" [PMID:14581499]
Show

Allelic Composition: Gli3tm1.1Zllr/Gli3tm1.2Zllr,Hoxa13tm1.1(cre)Makm/Hoxa13+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009836 abnormal sperm principal piece morphology "any structural abnormality in the segment of the sperm flagellum where the mitochondrial sheath ends and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs; the principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece" [PMID:14581499]
Show

Allelic Composition: Gli3tm1.1Zllr/Gli3tm1.2Zllr,Hoxa13tm1.1(cre)Makm/Hoxa13+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009838 abnormal sperm axoneme morphology "any structural abnormality of the central core of the sperm flagellum, composed of a ring of 9 outer microtubule doublets surrounding a central pair; inner and outer dynein arms project from each of the outer 9 doublets, and these arms are responsible for generating the motive force of the flagellum; in addition, 9 radial spokes, each of which originates from 1 of the 9 outer microtubular doublet pairs, project inward toward the central pair in a helical fashion" [PMID:14581499]
Show

Allelic Composition: Gli3tm1.1Zllr/Gli3tm1.2Zllr,Hoxa13tm1.1(cre)Makm/Hoxa13+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010831 partial lethality "the appearance of lower than Mendelian ratios of offspring of a given genotype due to death of some, but not all of the organisms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gli3tm1.1Zllr/Gli3tm1.2Zllr,Hoxa13tm1.1(cre)Makm/Hoxa13+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010854 lung situs inversus "anomaly in the asymmetry of the lung such that lung lobes on both the left and right side have the morphology normally seen on the opposite side of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gli3tm1.1Zllr/Gli3tm1.2Zllr,Hoxa13tm1.1(cre)Makm/Hoxa13+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011050 abnormal respiratory motile cilium morphology "any structural anomaly of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the respiratory tract" [GO:0031514, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gli3tm1.1Zllr/Gli3tm1.2Zllr,Hoxa13tm1.1(cre)Makm/Hoxa13+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr