| MP:0000063 | reduced bone density | "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315] |
Show
Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0000130 | abnormal cancellous bone morphology | "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Gsdma3Bsk/Gsdma3Bsk
Genetic Background: Not Specified
|
| MP:0000182 | increased circulating LDL cholesterol level | "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
|
| MP:0000186 | decreased circulating HDL cholesterol level | "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
|
| MP:0000218 | increased WBC count | "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0000230 | abnormal blood pressure | "altered tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0000231 | hypertension | "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
|
| MP:0000321 | increased bone marrow cell number | "increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0000322 | increased granulocyte number | "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0000598 | abnormal liver morphology | "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170] |
Show
Allelic Composition: Gtf2ird1tm1Hrd/Gtf2ird1tm1Hrd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
| MP:0000599 | enlarged liver | "larger than average size of the liver" [J:65146] |
Show
Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6
|
| MP:0000603 | pale liver | "liver lacking normal coloration, often refers to bloodless condition" [J:18048] |
Show
Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6
|
| MP:0000609 | abnormal liver physiology | "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0000613 | abnormal salivary gland morphology | "malformed saliva-secreting glands of the oral cavity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:63764] |
Show
Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv
|
| MP:0000659 | prostate gland hyperplasia | "increased cell number in the prostate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63764] |
Show
Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0000691 | enlarged spleen | "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0000693 | spleen hyperplasia | "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401] |
Show
Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0001121 | uterine hypoplasia | "reduced size of the uterus due to decreased cell number" [J:45065] |
Show
Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0001126 | abnormal ovary morphology | "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782] |
Show
Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv
Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac
|
| MP:0001129 | impaired ovarian folliculogenesis | "a block in the formation of the spherical ovum in the ovary" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac
|
| MP:0001131 | abnormal ovarian follicles | "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042] |
Show
Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac
|
| MP:0001134 | absent corpora lutea | "missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782] |
Show
Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv
Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac
|
| MP:0001145 | abnormal male reproductive anatomy | "anomalous structure of the organs associated with producing offspring in the gender that produces spermatozoa" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0001152 | Leydig cell hyperplasia | "increased number of interstitial cells of the seminiferous tubules that secrete testosterone" [J:45065] |
Show
Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0001156 | abnormal spermatogenesis | "incomplete maturation or aberrant formation of the male gametes" [J:58959] |
Show
Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac
|
| MP:0001260 | increased body weight | "greater than normal average weight " [J:33400] |
Show
Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
|
| MP:0001261 | obese | "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0001356 | increased aggression towards females | "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward female mice" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9] |
Show
Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv
Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv * C57BL/6
|
| MP:0001377 | abnormal copulation | "reduced or absent attempt of sexual contact between a male and a receptive female " [MeSH:National Library of Medicine - Medical Subject Headings, 2003] |
Show
Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac
|
| MP:0001380 | male reduced copulation without impotence | "males do not initiate sexual behavior as scored by the presence of copulation plugs (not due to infertility)" [J:57125] |
Show
Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv
Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv * C57BL/6
|
| MP:0001441 | increased grooming behavior | "increased amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Kmt2atm1Saam/Kmt2a+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
|
| MP:0001552 | increased circulating triglyceride level | "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416] |
Show
Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
|
| MP:0001556 | increased circulating HDL cholesterol level | "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439] |
Show
Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac
|
| MP:0001750 | increased circulating follicle stimulating hormone level | "higher than normal levels in the blood stream of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [J:35782, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0001751 | increased circulating luteinizing hormone level | "higher than the normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35782, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0001859 | kidney inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
Show
Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0001870 | salivary gland inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the salivary gland" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
Show
Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv
|
| MP:0001919 | abnormal reproductive system physiology | "anomaly in the function of the organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0001922 | reduced male fertility | "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340] |
Show
Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv
Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv * C57BL/6
|
| MP:0001925 | male infertility | "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409] |
Show
Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv * C57BL/6
|
| MP:0001926 | female infertility | "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193] |
Show
Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv
|
| MP:0001932 | abnormal spermiogenesis | "failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0002016 | ovarian cysts | "cystic ovary; usually refers to a benign growth" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782] |
Show
Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac
|
| MP:0002068 | abnormal parental behavior | "altered behavior of animals towards offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv * C57BL/6
|
| MP:0002075 | abnormal coat color | "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0002078 | abnormal glucose homeostasis | "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Bcl2l1tm1Mam/Bcl2l1tm1Mam
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6
|
| MP:0002079 | increased circulating insulin level | "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac
|
| MP:0002118 | abnormal lipid homeostasis | "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Gsdma3Bsk/Gsdma3Bsk
Genetic Background: Not Specified
|
| MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: PhexHyp/PhexHyp
Genetic Background: B6.Cg-PhexHyp/J
|
| MP:0002211 | abnormal primary sex determination | "aberrant gonadal development resulting in either abnormal or absent gonads or the development of gonads inconsistent with the chromosomal sex " [llw2:Linda Washburn , Mouse Genome Informatics Curator, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac
|
| MP:0002216 | abnormal seminiferous tubule morphology | "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0002359 | abnormal spleen germinal center morphology | "anomalous structure or formation of the area of the spleen in which activated follicles are located" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0] |
Show
Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0002493 | increased IgG | "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0002566 | abnormal sexual interaction | "altered initiation, failure of initiation or incomplete mating behavior" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Gsdma3Bsk/Gsdma3Bsk
Genetic Background: Not Specified
Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv * C57BL/6
|
| MP:0002572 | abnormal emotion/affect behavior | "altered response in tests for emotional related behaviors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Kmt2atm1Saam/Kmt2a+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
|
| MP:0002626 | increased heart rate | "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0002628 | fatty liver | "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
|
| MP:0002631 | abnormal epididymis morphology | "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0002637 | small uterus | "reduced size of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0002675 | asthenozoospermia | "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac
|
| MP:0002687 | oligozoospermia | "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312] |
Show
Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac
|
| MP:0002727 | decreased circulating insulin level | "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
|
| MP:0002777 | absent ovarian follicles | "lack of the sac-like structures in the ovaries that surround the ova" [J:42612, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0002781 | increased circulating testosterone level | "greater than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0002808 | barbering | "the biting and ingesting of hair (self, mate, pups); recognized as patches of unevenly chopped hair; seldom is the underlying skin inflamed" [What s wrong with my mouse?:ISBN 0-471-31639-3] |
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Allelic Composition: Kmt2atm1Saam/Kmt2a+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
|
| MP:0002842 | increased blood pressure | "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
|
| MP:0002962 | increased protein excretion | "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission] |
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0002970 | abnormal white fat morphology | "structural aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv
|
| MP:0002981 | increased liver weight | "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
|
| MP:0003313 | abnormal locomotor activation | "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Kmt2atm1Saam/Kmt2a+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
|
| MP:0003356 | impaired lutenization | "atypical transformation of the mature ovarian follicle and its theca interna into a corpus luteum after ovulation" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:57854, J:43075] |
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Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0003509 | increased circulating levels of dihydrotestosterone | "greater than normal blood concentration of this potent androgenic metabolite of testosterone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0003511 | abnormal labium morphology | "malformation of the folds of skin which form the inner lips (labia minora) and outer lips (labia majora) on both sides of the vaginal opening " [ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0003529 | enlarged clitoris | "increased size of the small, erectile body located at the anterior end of the vulva" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0003572 | abnormal uterus development | "abnormal morphogenesis of the female muscular organ of gestation" [ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv
|
| MP:0003607 | abnormal prostate physiology | "malfunction of the gland in males that secretes part of the seminiferous fluid" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0003725 | increased autoantibody level | "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator] |
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv
|
| MP:0003797 | abnormal compact bone morphology | "structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator] |
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Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0003862 | decreased aggression towards males | "when compared to controls, subjects exhibit less than normal level of domineering, assaultive posture and/or hostile physical action towards male mice " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv * C57BL/6
|
| MP:0003929 | decreased heart rate variability | "reduced variation of beat-to-beat intervals of the heart, usually indicitive of cardiac disease" [RGD:Rat Genome Database submission] |
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0003961 | decreased lean body mass | "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator] |
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Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac
|
| MP:0004016 | decreased bone mass | "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0004184 | abnormal baroreceptor physiology | "anomaly in the function of the sensory nerve endings found in the wall of the atria of the heart, vena cava, aortic arch and carotid sinus that are sensitive to changes in blood pressure" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0004738 | abnormal brainstem auditory evoked potential | "anomaly in the electrical activity generated in response to short tone bursts; may be used to evaluate sensorineural hearing function" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac
|
| MP:0004771 | increased anti-single stranded DNA antibody level | "increase in the level of antibodies that recognize single stranded DNA" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv
|
| MP:0004834 | ovary hemorrhage | "presence of bleeding in the ovary" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac
|
| MP:0004852 | decreased testis weight | "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0004876 | decreased mean arterial blood pressure | "decrease in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0004901 | decreased male germ cell number | "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0004905 | decreased uterus weight | "reduction in the weight of the female organ of gestation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv
|
| MP:0004909 | increased seminal gland weight | "increase in the weight of one or both of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0004958 | enlarged prostate | "increased size of the gland in males that secretes part of the seminiferous fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0004961 | increased prostate weight | "greater than average weight of the gland in males that secretes part of the seminiferous fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0004984 | increased osteoclast cell number | "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0004992 | increased bone resorption | "greater than average amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0005013 | increased lymphocyte number | "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0005014 | increased B cell number | "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0005124 | increased circulating prolactin level | "greater than expected blood concentration of the hormone that stimulates milk secretion " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0005145 | increased circulating VLDL cholesterol level | "greater than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
|
| MP:0005156 | bradykinesia | "decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301] |
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Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac
|
| MP:0005178 | increased total circulating cholesterol level | "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
|
| MP:0005181 | decreased circulating estradiol level | "less than the normal blood concentration of this most potent naturally occurring estrogen in mammals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0005293 | impaired glucose tolerance | "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
|
| MP:0005319 | abnormal enzyme/ coenzyme level | "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0005331 | insulin resistance | "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
|
| MP:0005335 | abnormal gonadal fat pad | "malformed or aberrant size of the encapsulated adipose tissue associated with the ovaries or testes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:84541] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
|
| MP:0005338 | atherosclerotic lesions | "thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
|
| MP:0005350 | increased susceptibility to autoimmune disorders | "greater likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv
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| MP:0005425 | increased macrophage count | "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418] |
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Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv
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| MP:0005455 | increased weight gain | "greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702] |
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Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0005559 | increased circulating glucose level | "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission] |
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Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
|
| MP:0005599 | increased cardiac muscle contractility | "greater than the normal ability of the heart muscle to shorten or to develop increased tension
" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission] |
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0005656 | decreased aggression | "when compared to controls, subjects exhibit less than the normal level of domineering, assaultive posture and/or hostile physical action" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator] |
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Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0005669 | increased circulating leptin level | "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751] |
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Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac
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| MP:0006094 | adipocyte hypertrophy | "increase in the size of fat cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:90802] |
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Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
|
| MP:0006263 | decreased diastolic blood pressure | "abnormal decrease in the pressure in the arteries between heart beats when the heart is relaxed" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887] |
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0006362 | abnormal male germ cell morphology | "any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0006380 | abnormal spermatid morphology | "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0008126 | increased dendritic cell number | "greater number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv
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| MP:0008210 | increased mature B cell number | "greater number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149] |
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0008257 | thin myometrium | "reduced thickness of the smooth muscle coat of the uterus, which forms the main mass of the organ and surrounds and supports the endometrium" [MESH:A02.633.570.500, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0008258 | thin endometrium | "reduced thickness of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy" [MESH:A05.360.319.679.490, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0008279 | arrest of spermiogenesis | "block in the process by which a spermatid transforms into a functional spermatozoon" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0008280 | male germ cell apoptosis | "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0008431 | abnormal short-term spatial reference memory | "anomaly in the short-term memory for spatial location information that is established during the first few minutes after training or an encouter at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Kmt2atm1Saam/Kmt2a+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
|
| MP:0008466 | enlarged mesenteric lymph nodes | "increased size of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0008553 | increased circulating tumor necrosis factor level | "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
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| MP:0008596 | increased circulating interleukin-6 level | "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
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| MP:0008868 | abnormal granulosa cell morphology | "any structural anomaly of a supporting cell for the developing female gamete in the ovary of mammals; granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle" [MESH:A.05.360.319.114.630.535.200] |
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0008869 | anovulation | "complete failure of ovum to be released from an ovarian follicle" [MESH:C13.351.500.056.630.050, MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0008880 | lacrimal gland inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the glands that secrete tears" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv
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| MP:0008898 | abnormal acrosome morphology | "any structural anomaly of the cap-like structure at the anterior end of the sperm head that produces enzymes needed for egg penetration" [MESH:A05.360.490.890.820.100] |
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0008987 | abnormal liver lobule morphology | "any structural anomaly of the polygonal structure of the liver that consists of hepatocytes radiating outward from a hepatic vein" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0009285 | increased gonadal fat pad weight | "greater than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac
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| MP:0009286 | increased abdominal fat pad weight | "greater than average weight of the encapsulated adipose tissue in the abdomen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0009296 | increased mammary fat pad weight | |
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0009302 | increased renal fat pad weight | |
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Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac
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| MP:0009364 | abnormal mature ovarian follicle morphology | "any structural abnormality in the ovarian follicle that is ready for ovulation and presents a blanched spot (the follicular stigma) where the graafian follicle is about to rupture on the surface of the ovary; a first maturation (meiotic) division of the primary oocyte usually occurs just prior to rupture of the follicle" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac
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| MP:0009516 | enlarged salivary gland | "increased size of the saliva-secreting glands of the oral cavity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0009697 | abnormal copulation | "an anomaly in sexual union that normally enables the transfer of ejaculate (sperm) from male to female, sometimes resulting in the fertilization of an egg" [GO:0007620, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv * C57BL/6
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| MP:0009856 | failure of ejaculation | "inability to propulse semen from the genital ducts and the urethra to the exterior within a defined test period" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv * C57BL/6
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| MP:0010024 | increased total body fat amount | "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv
Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac
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| MP:0010210 | abnormal circulating cytokine level | "deviation from the normal levels in the blood of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
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| MP:0010867 | abnormal bone trabecula morphology | "any structural anomaly of the network of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0011572 | abnormal aorta bulb morphology | "any structural anomaly of the portion of the left ventricular outflow tract delineated by the sinotubular ridge superiorly and the bases of the valve leaflets inferiorly; it comprises the aortic sinuses, the aortic valve leaflets, the commissures, and the interleaflet triangles" [MGI:csmith, PMID:10722531] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
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| MP:0011750 | abnormal seminiferous tubule epithelium morphology | "any structural anomaly of the stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule" [MGI:csmith] |
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0013507 | increased ovary apotosis | "increase in the timing or the number of ovary cells undergoing programmed cell death" [MGI:csmith] |
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Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0013508 | increased granulosa cell apoptosis | "increase in the timing or the number of granulsa cells undergoing programmed cell death" [MGI:csmith] |
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0020411 | increased abdominal adipose tissue amount | "increase in amount of adipose tissue associated with internal organs" [MGI:anna] |
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Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv
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| MP:0020519 | renal glomerular immunoglobulin deposits | "any anomalous accumulation of immunoglobulins in the renal glomerulus" [PMID:12764198, PMID:17685926] |
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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