ENSMUSG00000032306


Mus musculus

Features
Gene ID: ENSMUSG00000032306
  
Biological name :Mpi
  
Synonyms : mannose phosphate isomerase / Mpi / Q924M7
  
Possible biological names infered from orthology : P34949
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: B
Gene start: 57544256
Gene end: 57552763
  
Corresponding Affymetrix probe sets: 10593937 (MoGene1.0st)   1451540_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034856
Ensembl peptide - ENSMUSP00000119342
NCBI entrez gene - 110119     See in Manteia.
MGI - MGI:97075
RefSeq - XM_006510771
RefSeq - NM_025837
RefSeq Peptide - NP_080113
swissprot - Q3V100
swissprot - Q924M7
swissprot - F6Q3K8
Ensembl - ENSMUSG00000032306
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mpiENSDARG00000030786Danio rerio
 MPIENSGALG00000029296Gallus gallus
 MPIENSG00000178802Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001250  Mannose-6-phosphate isomerase, type I
 IPR011051  RmlC-like cupin domain superfamily
 IPR014710  RmlC-like jelly roll fold
 IPR016305  Mannose-6-phosphate isomerase
 IPR018050  Phosphomannose isomerase, type I, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000032 cell wall mannoprotein biosynthetic process IBA
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006486 protein glycosylation IBA
 biological_processGO:0009298 GDP-mannose biosynthetic process IEA
 biological_processGO:0061611 mannose to fructose-6-phosphate metabolic process IMP
 biological_processGO:0061619 glycolytic process from mannose through fructose-6-phosphate IC
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004476 mannose-6-phosphate isomerase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of GDP-mannose


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
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Allelic Composition: Trp53tm1Tyj/Trp53+,Trp53bp2tm1Xlu/Trp53bp2+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm1Tyj/Trp53+,Trp53bp2tm1Xlu/Trp53bp2+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J

 MP:0000350 abnormal cell proliferation "anomalous growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Trp53tm1Tyj/Trp53+,Trp53bp2tm1Xlu/Trp53bp2+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J

 MP:0001711 abnormal placenta 
Show

Allelic Composition: Trp53tm1Tyj/Trp53+,Trp53bp2tm1Xlu/Trp53bp2+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
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Allelic Composition: Trp53tm1Tyj/Trp53+,Trp53bp2tm1Xlu/Trp53bp2+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
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Allelic Composition: Trp53tm1Tyj/Trp53+,Trp53bp2tm1Xlu/Trp53bp2+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J

 MP:0002824 abnormal chorioallantoic fusion "abnormal process of or failure of the formation of the membrane that forms the fetal portion of the placenta; derived from the fusion of the chorion and the allantois" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+,Trp53bp2tm1Xlu/Trp53bp2+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+,Trp53bp2tm1Xlu/Trp53bp2+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm1Tyj/Trp53+,Trp53bp2tm1Xlu/Trp53bp2+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J

 MP:0004073 caudal body truncation "caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+,Trp53bp2tm1Xlu/Trp53bp2+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J

 MP:0004188 delayed embryo turning "completion of axial rotation occurs later than in controls but is eventually completed" [smb:Susan M Bello, Mouse Genome Informatics Curator ""]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+,Trp53bp2tm1Xlu/Trp53bp2+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J

 MP:0004255 abnormal spongiotrophoblast layer morphology "anomaly in the structure of the outer structural layer of the rodent placenta" [PMID:11433360]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+,Trp53bp2tm1Xlu/Trp53bp2+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J

 MP:0005031 abnormal trophoblast "malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+,Trp53bp2tm1Xlu/Trp53bp2+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+,Trp53bp2tm1Xlu/Trp53bp2+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J

 MP:0009141 increased prepulse inhibition "increase in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+,Trp53bp2tm1Xlu/Trp53bp2+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+,Trp53bp2tm1Xlu/Trp53bp2+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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