ENSMUSG00000032534


Mus musculus

Features
Gene ID: ENSMUSG00000032534
  
Biological name :Cep63
  
Synonyms : Centrosomal protein of 63 kDa / Cep63 / Q3UPP8
  
Possible biological names infered from orthology : centrosomal protein 63 / Q96MT8
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: F1
Gene start: 102584588
Gene end: 102626534
  
Corresponding Affymetrix probe sets: 10596117 (MoGene1.0st)   10596119 (MoGene1.0st)   1438409_at (Mouse Genome 430 2.0 Array)   1446482_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000125621
Ensembl peptide - ENSMUSP00000124836
Ensembl peptide - ENSMUSP00000125705
Ensembl peptide - ENSMUSP00000150899
Ensembl peptide - ENSMUSP00000150702
Ensembl peptide - ENSMUSP00000149157
Ensembl peptide - ENSMUSP00000091306
Ensembl peptide - ENSMUSP00000123954
NCBI entrez gene - 28135     See in Manteia.
MGI - MGI:2158560
RefSeq - XM_017313415
RefSeq - XM_011242891
RefSeq - XM_017313406
RefSeq - XM_017313407
RefSeq - XM_017313408
RefSeq - XM_017313409
RefSeq - XM_017313410
RefSeq - XM_017313411
RefSeq - XM_017313412
RefSeq - XM_017313413
RefSeq - XM_017313414
RefSeq - NM_001081122
RefSeq - NM_001301689
RefSeq - XM_006511739
RefSeq - XM_006511741
RefSeq - XM_006511744
RefSeq - XM_006511745
RefSeq - XM_006511747
RefSeq - XM_011242882
RefSeq - XM_011242883
RefSeq - XM_011242884
RefSeq - XM_011242885
RefSeq - XM_011242886
RefSeq - XM_011242890
RefSeq Peptide - NP_001288618
RefSeq Peptide - NP_001074591
swissprot - E0CX88
swissprot - F8VPJ7
swissprot - A0A1L1SUS8
swissprot - U5KVR9
swissprot - A0A1L1SUB9
swissprot - E0CZ48
swissprot - Q3UPP8
swissprot - E0CYR4
Ensembl - ENSMUSG00000032534
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cep63ENSDARG00000056862Danio rerio
 CEP63ENSGALG00000006632Gallus gallus
 CEP63ENSG00000182923Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Deup1 / Q7M6Y5 / Deuterosome assembly protein 1 / Q05D60*ENSMUSG0000003997719


Protein motifs (from Interpro)
Interpro ID Name
 IPR029608  Centrosomal protein of 63kDa
 IPR031470  Centrosomal protein Cep63/Deup1, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000077 DNA damage checkpoint ISS
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007099 centriole replication IEA
 biological_processGO:0007131 reciprocal meiotic recombination IMP
 biological_processGO:0042770 signal transduction in response to DNA damage ISS
 biological_processGO:0045141 meiotic telomere clustering IMP
 biological_processGO:0051225 spindle assembly ISS
 biological_processGO:0051298 centrosome duplication IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0071539 protein localization to centrosome IMP
 biological_processGO:0098535 de novo centriole assembly involved in multi-ciliated epithelial cell differentiation IBA
 biological_processGO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator IGI
 cellular_componentGO:0000922 spindle pole ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005814 centriole IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tardbptm2(TARDBP*A382T/Venus)Okn/Tardbp+
Genetic Background: Not Specified

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Tardbptm2(TARDBP*A382T/Venus)Okn/Tardbp+
Genetic Background: Not Specified

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Tardbptm2(TARDBP*A382T/Venus)Okn/Tardbp+
Genetic Background: Not Specified

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Tardbptm2(TARDBP*A382T/Venus)Okn/Tardbp+
Genetic Background: Not Specified

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Tardbptm2(TARDBP*A382T/Venus)Okn/Tardbp+
Genetic Background: Not Specified

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Tardbptm2(TARDBP*A382T/Venus)Okn/Tardbp+
Genetic Background: Not Specified

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tardbptm2(TARDBP*A382T/Venus)Okn/Tardbp+
Genetic Background: Not Specified

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Tardbptm2(TARDBP*A382T/Venus)Okn/Tardbp+
Genetic Background: Not Specified

 MP:0001940 testicular hypoplasia "decreased cell number in the testicles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tardbptm2(TARDBP*A382T/Venus)Okn/Tardbp+
Genetic Background: Not Specified

 MP:0003830 abnormal testis development "abnormal morphogenesis of the male reproductive gland containing the germ cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:100020]
Show

Allelic Composition: Tardbptm2(TARDBP*A382T/Venus)Okn/Tardbp+
Genetic Background: Not Specified

 MP:0004025 polyploidy "more than two chromosome sets are present" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tardbptm2(TARDBP*A382T/Venus)Okn/Tardbp+
Genetic Background: Not Specified

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tardbptm2(TARDBP*A382T/Venus)Okn/Tardbp+
Genetic Background: Not Specified

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tardbptm2(TARDBP*A382T/Venus)Okn/Tardbp+
Genetic Background: Not Specified

 MP:0004981 decreased neuronal precursor cell number "reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tardbptm2(TARDBP*A382T/Venus)Okn/Tardbp+
Genetic Background: Not Specified

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tardbptm2(TARDBP*A382T/Venus)Okn/Tardbp+
Genetic Background: Not Specified

 MP:0005169 abnormal male meiosis "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tardbptm2(TARDBP*A382T/Venus)Okn/Tardbp+
Genetic Background: Not Specified

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tardbptm2(TARDBP*A382T/Venus)Okn/Tardbp+
Genetic Background: Not Specified

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
Show

Allelic Composition: Tardbptm2(TARDBP*A382T/Venus)Okn/Tardbp+
Genetic Background: Not Specified

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Cep63Gt(EUCE0251h11)Hmgu/Cep63Gt(EUCE0251h11)Hmgu
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Cep63Gt(EUCE0251h11)Hmgu/Cep63Gt(EUCE0251h11)Hmgu,Chek2tm1Mak/Chek2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0006378 abnormal spermatogonia morphology "anomaly in the number, structure or development of the large unspecialized male germ cells that give rise to spermatocytes" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tardbptm2(TARDBP*A382T/Venus)Okn/Tardbp+
Genetic Background: Not Specified

 MP:0006379 abnormal spermatocyte morphology "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tardbptm2(TARDBP*A382T/Venus)Okn/Tardbp+
Genetic Background: Not Specified

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tardbptm2(TARDBP*A382T/Venus)Okn/Tardbp+
Genetic Background: Not Specified

 MP:0008458 abnormal cortical ventricular zone morphology "any structural anomaly of a transient region of the developing cerebral cortex that contains migrating neurons, radial glial cells, and a large population of cycling multipotent neural stem cells that generate newborn neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tardbptm2(TARDBP*A382T/Venus)Okn/Tardbp+
Genetic Background: Not Specified

 MP:0009452 abnormal synaptonemal complex "an anomaly in the formation of the proteinaceous structure involved in the pairing of homologous chromosomes during first prophase of meiosis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tardbptm2(TARDBP*A382T/Venus)Okn/Tardbp+
Genetic Background: Not Specified

 MP:0009760 abnormal mitotic spindle "an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during mitosis" [ISBN:8185198691 "Rieger R et al Eds Glossary of Genetics Classical and Molecular"]
Show

Allelic Composition: Tardbptm2(TARDBP*A382T/Venus)Okn/Tardbp+
Genetic Background: Not Specified

 MP:0010207 abnormal telomere morphology "any structural anomaly of the terminal repetitive DNA section of a chromosome which is involved in chromosomal replication and senescence, and which protects the end of the chromosome from deterioration" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tardbptm2(TARDBP*A382T/Venus)Okn/Tardbp+
Genetic Background: Not Specified

 MP:0010948 abnormal double-strand DNA break repair "any annomaly in the process of repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix" [GO:0006302]
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Allelic Composition: Tardbptm2(TARDBP*A382T/Venus)Okn/Tardbp+
Genetic Background: Not Specified

 MP:0012138 decreased forebrain size "size reduction or truncation of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
Show

Allelic Composition: Tardbptm2(TARDBP*A382T/Venus)Okn/Tardbp+
Genetic Background: Not Specified

 MP:0012504 increased forebrain apoptosis "increase in the number of cells of the forebrain undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Tardbptm2(TARDBP*A382T/Venus)Okn/Tardbp+
Genetic Background: Not Specified

 MP:0013601 increased testis apoptosis "increase in the number of cells of the male reproductive glands undergoing programmed cell death" [MGI:Anna]
Show

Allelic Composition: Tardbptm2(TARDBP*A382T/Venus)Okn/Tardbp+
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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