Manteia - Molecule gene

ENSMUSG00000032575

Mus musculus

Features

Gene ID:	ENSMUSG00000032575

Biological name :	Manf

Synonyms :	Manf / mesencephalic astrocyte derived neurotrophic factor

Possible biological names infered from orthology :

Species:	Mus musculus

Chr. number:	9
Strand:	-1
Band:	F1
Gene start:	106838312
Gene end:	106891979

Corresponding Affymetrix probe sets:	10596575 (MoGene1.0st) 1428112_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000125424 Ensembl peptide - ENSMUSP00000124453 Ensembl peptide - ENSMUSP00000123907 Ensembl peptide - ENSMUSP00000124562 Ensembl peptide - ENSMUSP00000066534 NCBI entrez gene - 74840 See in Manteia. MGI - MGI:1922090 RefSeq - NM_029103 RefSeq Peptide - NP_083379 swissprot - Q80ZP8 swissprot - F6T4L3 swissprot - F6USD5 swissprot - F7C1S6 swissprot - Q3TMX5 Ensembl - ENSMUSG00000032575

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
manf	ENSDARG00000063177	Danio rerio
MANF	ENSGALG00000002362	Gallus gallus
MANF	ENSG00000145050	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Cdnf / Q8CC36 / Cerebral dopamine neurotrophic factor / Q49AH0*	ENSMUSG00000039496	54

Protein motifs (from Interpro)

Interpro ID	Name
IPR011001	Saposin-like
IPR019345	Armet protein
IPR036361	SAP domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
cellular_component	GO:0005575	cellular_component	ND
cellular_component	GO:0005615	extracellular space	IEA
cellular_component	GO:0005783	endoplasmic reticulum	IEA
cellular_component	GO:0048471	perinuclear region of cytoplasm	IEA
molecular_function	GO:0003674	molecular_function	ND

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Notch2^tm2.1Ecan/Notch2^tm2.1Ecan,Tg(BGLAP-cre)1Clem/0 Genetic Background: involves: C57BL/6J * FVB/NJ
MP:0001426	polydipsia	"excessive thirst that is relatively prolonged" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Notch2^tm2.1Ecan/Notch2^tm2.1Ecan,Tg(BGLAP-cre)1Clem/0 Genetic Background: involves: C57BL/6J * FVB/NJ
MP:0001559	hyperglycemia	"abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Notch2^tm2.1Ecan/Notch2^tm2.1Ecan,Tg(BGLAP-cre)1Clem/0 Genetic Background: involves: C57BL/6J * FVB/NJ Allelic Composition: Manf^{tm1c(KOMP)Wtsi}/Manf^{tm1c(KOMP)Wtsi} Genetic Background: involves: C57BL/6N * FVB/N
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Notch2^tm2.1Ecan/Notch2^tm2.1Ecan,Tg(BGLAP-cre)1Clem/0 Genetic Background: involves: C57BL/6J * FVB/NJ
MP:0002078	abnormal glucose homeostasis	"anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Notch2^tm2.1Ecan/Notch2^tm2.1Ecan,Tg(BGLAP-cre)1Clem/0 Genetic Background: involves: C57BL/6J * FVB/NJ
MP:0002727	decreased circulating insulin level	"less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]	Show Allelic Composition: Notch2^tm2.1Ecan/Notch2^tm2.1Ecan,Tg(BGLAP-cre)1Clem/0 Genetic Background: involves: C57BL/6J * FVB/NJ Allelic Composition: Manf^{tm1c(KOMP)Wtsi}/Manf^{tm1c(KOMP)Wtsi} Genetic Background: involves: C57BL/6N * FVB/N
MP:0003339	decreased number of pancreatic beta cells	"fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Notch2^tm2.1Ecan/Notch2^tm2.1Ecan,Tg(BGLAP-cre)1Clem/0 Genetic Background: involves: C57BL/6J * FVB/NJ
MP:0004201	fetal growth retardation	"slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Notch2^tm2.1Ecan/Notch2^tm2.1Ecan,Tg(BGLAP-cre)1Clem/0 Genetic Background: involves: C57BL/6J * FVB/NJ
MP:0005334	abnormal fat pad	"malformed or aberrant size of the encapsulated adipose tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Notch2^tm2.1Ecan/Notch2^tm2.1Ecan,Tg(BGLAP-cre)1Clem/0 Genetic Background: involves: C57BL/6J * FVB/NJ
MP:0006009	abnormal neuronal migration	"defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Eprs^tm2.1Xen/Eprs^tm2.1Xen,Rps6kb1^tm1Nte/Rps6kb1^tm1Nte Genetic Background: involves: 129S1/Sv * 129X1/Sv * C57BL/6
MP:0006254	thin cerebral cortex	"decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]	Show Allelic Composition: Eprs^tm2.1Xen/Eprs^tm2.1Xen,Rps6kb1^tm1Nte/Rps6kb1^tm1Nte Genetic Background: involves: 129S1/Sv * 129X1/Sv * C57BL/6
MP:0008415	abnormal neurite morphology	"any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572]	Show Allelic Composition: Eprs^tm2.1Xen/Eprs^tm2.1Xen,Rps6kb1^tm1Nte/Rps6kb1^tm1Nte Genetic Background: involves: 129S1/Sv * 129X1/Sv * C57BL/6
MP:0008439	abnormal cortical plate morphology	"any strucutral anomaly of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236]	Show Allelic Composition: Eprs^tm2.1Xen/Eprs^tm2.1Xen,Rps6kb1^tm1Nte/Rps6kb1^tm1Nte Genetic Background: involves: 129S1/Sv * 129X1/Sv * C57BL/6
MP:0008441	thin cortical plate	"reduced thickness of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236]	Show Allelic Composition: Eprs^tm2.1Xen/Eprs^tm2.1Xen,Rps6kb1^tm1Nte/Rps6kb1^tm1Nte Genetic Background: involves: 129S1/Sv * 129X1/Sv * C57BL/6
MP:0008457	abnormal cortical intermediate zone morphology	"any structural anomaly of the region of the developing mammalian cortex that extends between the ventricular zone and the cortical plate (CP); normally, the IZ is a region of tangential migration of cells, and at midgestation, the lower part of the IZ develops into the subventricular zone" [PMID:10632599]	Show Allelic Composition: Eprs^tm2.1Xen/Eprs^tm2.1Xen,Rps6kb1^tm1Nte/Rps6kb1^tm1Nte Genetic Background: involves: 129S1/Sv * 129X1/Sv * C57BL/6
MP:0008489	postnatal slow weight gain	"the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Notch2^tm2.1Ecan/Notch2^tm2.1Ecan,Tg(BGLAP-cre)1Clem/0 Genetic Background: involves: C57BL/6J * FVB/NJ
MP:0009114	decreased pancreatic beta cell mass	"reduced total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Notch2^tm2.1Ecan/Notch2^tm2.1Ecan,Tg(BGLAP-cre)1Clem/0 Genetic Background: involves: C57BL/6J * FVB/NJ
MP:0009168	decreased pancreatic islet number	"reduction in the number of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]	Show Allelic Composition: Notch2^tm2.1Ecan/Notch2^tm2.1Ecan,Tg(BGLAP-cre)1Clem/0 Genetic Background: involves: C57BL/6J * FVB/NJ
MP:0009175	abnormal pancreatic beta cell differentiation	"atypical production of or inability to produce the cells of the pancreas that secrete insulin, and/or accumulation of pancreatic beta cell precursors" [MESH:A03.734.414.131]	Show Allelic Composition: Notch2^tm2.1Ecan/Notch2^tm2.1Ecan,Tg(BGLAP-cre)1Clem/0 Genetic Background: involves: C57BL/6J * FVB/NJ
MP:0012203	abnormal neuronal stem cell morphology	"any structural anomaly of an undifferentiated cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple types of lineage-restricted progenitors" [CL:0000047]	Show Allelic Composition: Eprs^tm2.1Xen/Eprs^tm2.1Xen,Rps6kb1^tm1Nte/Rps6kb1^tm1Nte Genetic Background: involves: 129S1/Sv * 129X1/Sv * C57BL/6
MP:0013220	increased pancreas apoptosis	"increase in the number of cells of the pancreas undergoing programmed cell death" [MGI:csmith]	Show Allelic Composition: Notch2^tm2.1Ecan/Notch2^tm2.1Ecan,Tg(BGLAP-cre)1Clem/0 Genetic Background: involves: C57BL/6J * FVB/NJ
MP:0013272	abnormal translation	"any anomaly in the cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain; translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA; translation ends with the release of a polypeptide chain from the ribosome" [GO:0006412]	Show Allelic Composition: Eprs^tm2.1Xen/Eprs^tm2.1Xen,Rps6kb1^tm1Nte/Rps6kb1^tm1Nte Genetic Background: involves: 129S1/Sv * 129X1/Sv * C57BL/6 Allelic Composition: Manf^{tm1a(KOMP)Wtsi}/Manf^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N * ICR
MP:0020599	increased cerebral cortex cell density	"increase of the density of cells of the cerebral cortex" [WTSI:vancollie]	Show Allelic Composition: Eprs^tm2.1Xen/Eprs^tm2.1Xen,Rps6kb1^tm1Nte/Rps6kb1^tm1Nte Genetic Background: involves: 129S1/Sv * 129X1/Sv * C57BL/6

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr