ENSMUSG00000032589


Mus musculus

Features
Gene ID: ENSMUSG00000032589
  
Biological name :Bsn
  
Synonyms : Bsn / O88737 / Protein bassoon
  
Possible biological names infered from orthology : bassoon presynaptic cytomatrix protein / Q9UPA5
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: F1
Gene start: 108096022
Gene end: 108190384
  
Corresponding Affymetrix probe sets: 10596880 (MoGene1.0st)   1422023_at (Mouse Genome 430 2.0 Array)   1436123_at (Mouse Genome 430 2.0 Array)   1450467_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000035208
Ensembl peptide - ENSMUSP00000139053
NCBI entrez gene - 12217     See in Manteia.
MGI - MGI:1277955
RefSeq - XM_006511634
RefSeq - NM_007567
RefSeq Peptide - NP_031593
swissprot - O88737
swissprot - V9GX98
Ensembl - ENSMUSG00000032589
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bsnbENSDARG00000079161Danio rerio
 CABZ01086611.1ENSDARG00000111110Danio rerio
 BSNENSGALG00000001849Gallus gallus
 BSNENSG00000164061Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pclo / Q9QYX7 / Protein piccolo / Q9Y6V0* / piccolo presynaptic cytomatrix protein*ENSMUSG0000006160133


Protein motifs (from Interpro)
Interpro ID Name
 IPR008899  Zinc finger, piccolo-type
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR030627  Protein bassoon


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007416 synapse assembly IEA
 biological_processGO:0035418 protein localization to synapse IGI
 biological_processGO:0048790 maintenance of presynaptic active zone structure IEA
 biological_processGO:0099526 presynapse to nucleus signaling pathway IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0019898 extrinsic component of membrane ISO
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0044306 neuron projection terminus IDA
 cellular_componentGO:0045202 synapse ISO
 cellular_componentGO:0048786 presynaptic active zone IEA
 cellular_componentGO:0060076 excitatory synapse ISS
 cellular_componentGO:0098793 presynapse IDA
 cellular_componentGO:0098831 presynaptic active zone cytoplasmic component IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0098882 structural constituent of presynaptic active zone IC


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000243 myoclonus "involuntary shock-like contractions, variable in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscles; generally due to a central nervous system lesion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Krt10tm1Der/Krt10+,Tg(KRT14-cre/PGR)1Der/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR

 MP:0000947 convulsive seizures "seizures characterized by uncontrolled motor activity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krt10tm1Der/Krt10+,Tg(KRT14-cre/PGR)1Der/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR

 MP:0001005 abnormal rod morphology "structural or developmental anomaly of the photoreceptors that contain rhodopsin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Krt10tm1Der/Krt10+,Tg(KRT14-cre/PGR)1Der/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Krt10tm1Der/Krt10+,Tg(KRT14-cre/PGR)1Der/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Krt10tm1Der/Krt10+,Tg(KRT14-cre/PGR)1Der/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krt10tm1Der/Krt10+,Tg(KRT14-cre/PGR)1Der/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Krt10tm1Der/Krt10+,Tg(KRT14-cre/PGR)1Der/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
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Allelic Composition: Krt10tm1Der/Krt10+,Tg(KRT14-cre/PGR)1Der/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR

 MP:0002917 decreased synaptic depression "decrease in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Krt10tm1Der/Krt10+,Tg(KRT14-cre/PGR)1Der/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR

 MP:0003635 abnormal synaptic transmission "defect in the communication from a neuron to a target across a synapse " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Krt10tm1Der/Krt10+,Tg(KRT14-cre/PGR)1Der/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR

 MP:0003996 clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by unilateral or bilateral rhythmic jerking movements of the arms and legs caused by alternating contraction and relaxation of muscle" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Krt10tm1Der/Krt10+,Tg(KRT14-cre/PGR)1Der/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR

 MP:0004417 decreased cochlear nerve compound action potential "reduction of the combined potentials resulting from activation of the auditory division of the eighth cranial nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Krt10tm1Der/Krt10+,Tg(KRT14-cre/PGR)1Der/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR

 MP:0004433 abnormal cochlear inner hair cell physiology "anomalies in processes pertinent to the function of cochlear IHCs which constitute the true sensory cell type sending impulses via the cochlear (auditory) nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Krt10tm1Der/Krt10+,Tg(KRT14-cre/PGR)1Der/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR

 MP:0004562 abnormal inner hair cell synaptic ribbon morphology "any structural abnormality in the presynaptic active zone of mature cochlear IHCs which usually contain a single synaptic ribbon, i.e. a submicrometer, electron-dense structure tethering synaptic vesicles; each spiral ganglion neuron receives input from only one IHC synapse" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Krt10tm1Der/Krt10+,Tg(KRT14-cre/PGR)1Der/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR

Allelic Composition: BsnGt(OST486029)Lex/BsnGt(OST486029)Lex
Genetic Background: Not Specified

 MP:0004563 absent active-zone-anchored inner hair cell synaptic ribbon "absence or loss of the usually single synaptic ribbon, a characteristic osmiophilic, electron-dense structure to which synaptic vesicles are tethered at the active zone of the cochlear inner hair cell afferent synapse" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Krt10tm1Der/Krt10+,Tg(KRT14-cre/PGR)1Der/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR

 MP:0004738 abnormal brainstem auditory evoked potential "anomaly in the electrical activity generated in response to short tone bursts; may be used to evaluate sensorineural hearing function" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krt10tm1Der/Krt10+,Tg(KRT14-cre/PGR)1Der/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR

 MP:0004792 abnormal synaptic vesicle number "anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Krt10tm1Der/Krt10+,Tg(KRT14-cre/PGR)1Der/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Krt10tm1Der/Krt10+,Tg(KRT14-cre/PGR)1Der/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR

 MP:0005423 abnormal somatic nervous system physiology "anomalous function of any of the cranial and spinal nerves or their ganglia or the peripheral sensory receptors" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Krt10tm1Der/Krt10+,Tg(KRT14-cre/PGR)1Der/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Krt10tm1Der/Krt10+,Tg(KRT14-cre/PGR)1Der/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR

Allelic Composition: BsnGt(OST486029)Lex/BsnGt(OST486029)Lex
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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