ENSMUSG00000032717


Mus musculus

Features
Gene ID: ENSMUSG00000032717
  
Biological name :Mdfi
  
Synonyms : Mdfi / MyoD family inhibitor / P70331
  
Possible biological names infered from orthology : Q99750
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: C
Gene start: 47815328
Gene end: 47834691
  
Corresponding Affymetrix probe sets: 10451604 (MoGene1.0st)   1420713_a_at (Mouse Genome 430 2.0 Array)   1425924_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000069915
Ensembl peptide - ENSMUSP00000108905
Ensembl peptide - ENSMUSP00000120454
Ensembl peptide - ENSMUSP00000117665
Ensembl peptide - ENSMUSP00000114930
Ensembl peptide - ENSMUSP00000114581
Ensembl peptide - ENSMUSP00000037888
NCBI entrez gene - 17240     See in Manteia.
MGI - MGI:107687
RefSeq - XM_006523745
RefSeq - NM_001109973
RefSeq - NM_001276390
RefSeq - NM_001276391
RefSeq - NM_010783
RefSeq - XM_006523743
RefSeq - XM_006523744
RefSeq Peptide - NP_001103443
RefSeq Peptide - NP_001263319
RefSeq Peptide - NP_001263320
RefSeq Peptide - NP_034913
swissprot - D3YVA0
swissprot - D3YUT8
swissprot - D3YZ53
swissprot - D3Z6Q8
swissprot - D3Z3N7
swissprot - P70331
Ensembl - ENSMUSG00000032717
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MDFIENSDARG00000089564Danio rerio
 MDFIENSGALG00000030377Gallus gallus
 MDFIENSG00000112559Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mdfic / Q8BX65 / MyoD family inhibitor domain-containing protein / Q9P1T7* / MyoD family inhibitor domain containing*ENSMUSG0000004139036


Protein motifs (from Interpro)
Interpro ID Name
 IPR026134  MyoD family inhibitor/MyoD family inhibitor domain-containing protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0048704 embryonic skeletal system morphogenesis IMP
 biological_processGO:0060707 trophoblast giant cell differentiation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000141 abnormal vertebral body morphology "malformed main portion of the vertebra anterior to the vertebral canal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
Show

Allelic Composition: Hand1tm1Jcc/Hand1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
Show

Allelic Composition: Hand1tm1Jcc/Hand1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000153 rib bifurcation "forking or division of ribs, may be a result of partial rib fusions" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hand1tm1Jcc/Hand1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
Show

Allelic Composition: Hand1tm1Jcc/Hand1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
Show

Allelic Composition: Hand1tm1Jcc/Hand1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000930 wavy neural tube "undulations in the embryonic neural tube" [J:37888]
Show

Allelic Composition: Hand1tm1Jcc/Hand1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Hand1tm1Jcc/Hand1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
Show

Allelic Composition: Hand1tm1Jcc/Hand1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001713 reduced trophoblast cell number "fewer than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:23171]
Show

Allelic Composition: Hand1tm1Jcc/Hand1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Hand1tm1Jcc/Hand1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hand1tm1Jcc/Hand1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002621 delayed neural tube closure "delayed fusion of the neuroepithelial layer in early development" [J:79790, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hand1tm1Jcc/Hand1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003051 curly tail "a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hand1tm1Jcc/Hand1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Hand1tm1Jcc/Hand1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Hand1tm1Jcc/Hand1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hand1tm1Jcc/Hand1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0004601 abnormal vertebral spinous process "any structural anomaly of the dorsal projection of the vertebral arch that projects backward and downward from the junction of the laminae, and serves for the attachment of muscles and ligaments" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hand1tm1Jcc/Hand1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0004677 truncated ribs "ribs that terminate abruptly as if having an end or point cut off" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hand1tm1Jcc/Hand1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0006029 abnormal sclerotome "malformation of the one or more of the masses of mesodermal tissue that is derived from the somites and is adjacent to the notochord that give rise to the ribs and vertebrae" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
Show

Allelic Composition: Hand1tm1Jcc/Hand1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0008148 abnormal rib-sternum attachment "any anomaly in the in the normal joining of the ribs to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hand1tm1Jcc/Hand1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Hand1tm1Jcc/Hand1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Hand1tm1Jcc/Hand1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Hand1tm1Jcc/Hand1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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