ENSMUSG00000032802


Mus musculus

Features
Gene ID: ENSMUSG00000032802
  
Biological name :Srxn1
  
Synonyms : Srxn1 / sulfiredoxin 1
  
Possible biological names infered from orthology : Q9BYN0
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: G3
Gene start: 152105516
Gene end: 152111376
  
Corresponding Affymetrix probe sets: 10477061 (MoGene1.0st)   1419942_at (Mouse Genome 430 2.0 Array)   1425351_at (Mouse Genome 430 2.0 Array)   1426875_s_at (Mouse Genome 430 2.0 Array)   1451680_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000046196
NCBI entrez gene - 76650     See in Manteia.
MGI - MGI:104971
RefSeq - NM_029688
RefSeq Peptide - NP_083964
swissprot - A2AQU8
Ensembl - ENSMUSG00000032802
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 srxn1ENSDARG00000079160Danio rerio
 SRXN1ENSGALG00000040625Gallus gallus
 SRXN1ENSG00000271303Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003115  ParB/Sulfiredoxin
 IPR016692  Sulfiredoxin
 IPR036086  ParB/Sulfiredoxin superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016209 antioxidant activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016667 oxidoreductase activity, acting on a sulfur group of donors IEA
 molecular_functionGO:0032542 sulfiredoxin activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001739 abnormal adrenal secretion "altered ability of the surparenal gland to secrete hormones " [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Krastm1.1Hbji/Krastm1.1Hbji,Trp53tm5Tyj/Trp53tm5Tyj
Genetic Background: involves: 129S4/SvJae

 MP:0001748 increased circulating adrenocorticotropin level "elevated concentration in the blood of the pituitary hormone that stimulates the secretion of adrenal cortical steroids and induces growth of the adrenal cortex " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Krastm1.1Hbji/Krastm1.1Hbji,Trp53tm5Tyj/Trp53tm5Tyj
Genetic Background: involves: 129S4/SvJae

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Trpv5Hcalc1/Trpv5Hcalc1
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Trpv5Hcalc1/Trpv5Hcalc1
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0005345 abnormal circulating corticosterone level "anomalous blood concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Krastm1.1Hbji/Krastm1.1Hbji,Trp53tm5Tyj/Trp53tm5Tyj
Genetic Background: involves: 129S4/SvJae

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Trpv5Hcalc1/Trpv5Hcalc1
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0009078 adrenal gland hyperplasia "overdevelopment or increased size, usually due to a increased number of cells, of the endocrine glands located above the kidney and responsible for hormone and epinephrine secretion" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Krastm1.1Hbji/Krastm1.1Hbji,Trp53tm5Tyj/Trp53tm5Tyj
Genetic Background: involves: 129S4/SvJae

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trpv5Hcalc1/Trpv5Hcalc1
Genetic Background: involves: C3H/HeH * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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