ENSMUSG00000032815


Mus musculus

Features
Gene ID: ENSMUSG00000032815
  
Biological name :Fanca
  
Synonyms : Fanca / Fanconi anemia group A protein homolog / Q9JL70
  
Possible biological names infered from orthology : Fanconi anemia complementation group A / O15360
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: E1
Gene start: 123268300
Gene end: 123318576
  
Corresponding Affymetrix probe sets: 10582501 (MoGene1.0st)   1418856_a_at (Mouse Genome 430 2.0 Array)   1452513_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000148306
Ensembl peptide - ENSMUSP00000045217
Ensembl peptide - ENSMUSP00000113125
Ensembl peptide - ENSMUSP00000116614
NCBI entrez gene - 14087     See in Manteia.
MGI - MGI:1341823
RefSeq - XM_006530666
RefSeq - XM_006530661
RefSeq - XM_006530662
RefSeq - XM_006530663
RefSeq - XM_006530664
RefSeq - XM_006530665
RefSeq - NM_016925
RefSeq Peptide - NP_058621
swissprot - F7CK17
swissprot - D3Z6Y5
swissprot - A0A1D5RLC1
swissprot - Q9JL70
Ensembl - ENSMUSG00000032815
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FO834799.1ENSDARG00000110103Danio rerio
 FANCAENSGALG00000000516Gallus gallus
 FANCAENSG00000187741Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003516  Fanconi anaemia group A protein
 IPR031729  Fanconi anaemia group A protein, N-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007140 male meiotic nuclear division IMP
 biological_processGO:0008584 male gonad development IMP
 biological_processGO:0008585 female gonad development IMP
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0045589 regulation of regulatory T cell differentiation IMP
 biological_processGO:0050727 regulation of inflammatory response IMP
 biological_processGO:0051090 regulation of DNA-binding transcription factor activity IMP
 biological_processGO:2000348 regulation of CD40 signaling pathway IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0043240 Fanconi anaemia nuclear complex IEA


Pathways (from Reactome)
Pathway description
Fanconi Anemia Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bmp4tm1Blh/Bmp4+,Bmp7tm1Kry/Bmp7+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

Allelic Composition: Fancatm1Wong/Fancatm1Wong
Genetic Background: involves: C57BL/6

 MP:0001116 small gonad "reduced size of the testis or the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Fancatm1Faw/Fancatm1Faw
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0001126 abnormal ovary morphology "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Fancatm1Wong/Fancatm1Wong
Genetic Background: involves: C57BL/6

Allelic Composition: Fancatm1Faw/Fancatm1Faw
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Fancatm1Wong/Fancatm1Wong
Genetic Background: involves: C57BL/6

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Fancatm1Wong/Fancatm1Wong
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Fancatm1Wong/Fancatm1Wong
Genetic Background: involves: C57BL/6

 MP:0001152 Leydig cell hyperplasia "increased number of interstitial cells of the seminiferous tubules that secrete testosterone" [J:45065]
Show

Allelic Composition: Fancatm1Faw/Fancatm1Faw
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Fancatm1Faw/Fancatm1Faw
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Bmp4tm1Blh/Bmp4+,Bmp7tm1Kry/Bmp7+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

Allelic Composition: Fancatm1Wong/Fancatm1Wong
Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * CD-1)

Allelic Composition: Fancatm1Wong/Fancatm1Wong
Genetic Background: involves: 129S6/SvEvTac

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Fancatm1Wong/Fancatm1Wong
Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * CD-1)

Allelic Composition: Fancatm1Faw/Fancatm1Faw
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Bmp4tm1Blh/Bmp4+,Bmp7tm1Kry/Bmp7+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

Allelic Composition: Fancatm1Wong/Fancatm1Wong
Genetic Background: involves: C57BL/6

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
Show

Allelic Composition: Bmp4tm1Blh/Bmp4+,Bmp7tm1Kry/Bmp7+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

Allelic Composition: Fancatm1Wong/Fancatm1Wong
Genetic Background: involves: C57BL/6

 MP:0001545 abnormal hematopoietic system physiology "anomalous function of the fluid and/or its suspended elements that circulate(s) through the heart, arteries, capillaries, and veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Faap20tm1(KOMP)Mbp/Faap20tm1(KOMP)Mbp,Fancatm1.1Wong/Fancatm1.1Wong
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fancatm1Wong/Fancatm1Wong
Genetic Background: involves: C57BL/6

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Fancatm1Faw/Fancatm1Faw
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Bmp4tm1Blh/Bmp4+,Bmp7tm1Kry/Bmp7+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

Allelic Composition: Fancatm1Wong/Fancatm1Wong
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Fancatm1Faw/Fancatm1Faw
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fancatm1Faw/Fancatm1Faw
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0002016 ovarian cysts "cystic ovary; usually refers to a benign growth" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Fancatm1Wong/Fancatm1Wong
Genetic Background: involves: C57BL/6

 MP:0002209 germ cell depletion "reduced numbers of any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bmp4tm1Blh/Bmp4+,Bmp7tm1Kry/Bmp7+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

Allelic Composition: Fancatm1Wong/Fancatm1Wong
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Fancatm1Wong/Fancatm1Wong
Genetic Background: involves: C57BL/6

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fancatm1Faw/Fancatm1Faw
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0002682 reduced number of mature ovarian follicles "fewer than normal numbers of spehroidal cell aggregations in the ovary containing the ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fancatm1Wong/Fancatm1Wong
Genetic Background: involves: C57BL/6

 MP:0002777 absent ovarian follicles "lack of the sac-like structures in the ovaries that surround the ova" [J:42612, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fancatm1Faw/Fancatm1Faw
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Fancatm1Faw/Fancatm1Faw
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0003702 abnormal chromosome morphology "anomalies in the structure of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information " [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lipetm2Rze/Lipetm2Rze,Tg(Ins2-cre)25Mgn/?
Genetic Background: involves: 129 * C57BL/6 * DBA

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmp4tm1Blh/Bmp4+,Bmp7tm1Kry/Bmp7+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0004028 chromosome breakage "chromosome instability in the from of increased frequency of spontaneous breakage with or without rearrangements" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Spi1tm1Sing/Spi1+,Spibtm1Mcs/Spib+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

 MP:0004029 spontaneous chromosome breakage "chromosome breakage due to inherent instability of chromosomes" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fancatm1Faw/Fancatm1Faw
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0004030 induced chromosome breakage "chromosome breakage following treatment with a DNA-damaging agent " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fancatm1Faw/Fancatm1Faw
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Fancatm1Faw/Fanca+
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0004834 ovary hemorrhage "presence of bleeding in the ovary" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fancatm1Wong/Fancatm1Wong
Genetic Background: involves: C57BL/6

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmp4tm1Blh/Bmp4+,Bmp7tm1Kry/Bmp7+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0005158 ovary hypoplasia "underdeveloped ovaries, usually due to reduced cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:78931]
Show

Allelic Composition: Fancatm1Wong/Fancatm1Wong
Genetic Background: involves: C57BL/6

 MP:0005169 abnormal male meiosis "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fancatm1Wong/Fancatm1Wong
Genetic Background: involves: 129S6/SvEvTac

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmp4tm1Blh/Bmp4+,Bmp7tm1Kry/Bmp7+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fancatm1Wong/Fancatm1Wong
Genetic Background: involves: 129S6/SvEvTac

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Albem12Mvw/Albem12Mvw,Fcgrttm1Dcr/Fcgrttm1Dcr,Tg(FCGRT)32Dcr/Tg(FCGRT)32Dcr
Genetic Background: B6.Cg-Albem12Mvw Fcgrttm1Dcr Tg(FCGRT)32Dcr/MvwJ

 MP:0008943 increased sensitivity to induced cell death "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Albem12Mvw/Albem12Mvw,Fcgrttm1Dcr/Fcgrttm1Dcr,Tg(FCGRT)32Dcr/Tg(FCGRT)32Dcr
Genetic Background: B6.Cg-Albem12Mvw Fcgrttm1Dcr Tg(FCGRT)32Dcr/MvwJ

 MP:0008995 early reproductive senescence "loss of reproductive capacity occurring at an earlier than expected age" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fancatm1Wong/Fancatm1Wong
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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