ENSMUSG00000032818


Mus musculus

Features
Gene ID: ENSMUSG00000032818
  
Biological name :Loxhd1
  
Synonyms : C8YR32 / Lipoxygenase homology domain-containing protein 1 / Loxhd1
  
Possible biological names infered from orthology : lipoxygenase homology domains 1 / Q8IVV2
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: E3
Gene start: 77281958
Gene end: 77442341
  
Corresponding Affymetrix probe sets: 10456846 (MoGene1.0st)   10456887 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000094294
Ensembl peptide - ENSMUSP00000120991
Ensembl peptide - ENSMUSP00000116287
Ensembl peptide - ENSMUSP00000114988
Ensembl peptide - ENSMUSP00000045450
NCBI entrez gene - 240411     See in Manteia.
MGI - MGI:1914609
RefSeq - NM_172834
RefSeq - XM_006526434
RefSeq Peptide - NP_766422
swissprot - E9PVB2
swissprot - F6XPZ0
swissprot - D3YUR7
swissprot - C8YR32
swissprot - F6QGA9
Ensembl - ENSMUSG00000032818
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 loxhd1aENSDARG00000094738Danio rerio
 loxhd1bENSDARG00000074638Danio rerio
 LOXHD1ENSGALG00000037829Gallus gallus
 LOXHD1ENSG00000167210Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001024  PLAT/LH2 domain
 IPR036392  PLAT/LH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0050982 detection of mechanical stimulus IBA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0016020 membrane IBA
 cellular_componentGO:0032420 stereocilium IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0004096 catalase activity IEA
 molecular_functionGO:0005262 calcium channel activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0020037 heme binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Myo7apolka/Myo7apolka
Genetic Background: involves: C57BL/6J

 MP:0001967 deafness "inability to hear" [J:57651]
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Allelic Composition: Lama5mpc205H/Lama5mpc205H
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

Allelic Composition: Loxhd1mpc231H/Loxhd1mpc231H
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0002622 abnormal cochlear hair cell morphology "malformation of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Myo7apolka/Myo7apolka
Genetic Background: involves: C57BL/6J

 MP:0002857 cochlear ganglion degeneration "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Myo7apolka/Myo7apolka
Genetic Background: involves: C57BL/6J

 MP:0004362 cochlear hair cell degeneration "degeneration or loss of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo7apolka/Myo7apolka
Genetic Background: involves: C57BL/6J

 MP:0004737 absent distortion product otoacoustic emissions "failure to create mechanical distortions in the inner ear when two primary tones are presented, indicating failure of outer hair cells to amplify basilar membrane motion" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo7apolka/Myo7apolka
Genetic Background: involves: C57BL/6J

 MP:0004738 abnormal brainstem auditory evoked potential "anomaly in the electrical activity generated in response to short tone bursts; may be used to evaluate sensorineural hearing function" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo7apolka/Myo7apolka
Genetic Background: involves: C57BL/6J

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Myo7apolka/Myo7apolka
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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