ENSMUSG00000032869


Mus musculus

Features
Gene ID: ENSMUSG00000032869
  
Biological name :Psmf1
  
Synonyms : proteasome (prosome, macropain) inhibitor subunit 1 / Psmf1 / Q8BHL8
  
Possible biological names infered from orthology : proteasome inhibitor subunit 1 / Q92530
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: G3
Gene start: 151715812
Gene end: 151744186
  
Corresponding Affymetrix probe sets: 10488575 (MoGene1.0st)   1424369_at (Mouse Genome 430 2.0 Array)   1424370_s_at (Mouse Genome 430 2.0 Array)   1424371_at (Mouse Genome 430 2.0 Array)   1451337_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000105495
Ensembl peptide - ENSMUSP00000117723
Ensembl peptide - ENSMUSP00000041184
NCBI entrez gene - 228769     See in Manteia.
MGI - MGI:1346072
RefSeq - NM_212446
RefSeq - XM_006499306
RefSeq - NM_001305244
RefSeq Peptide - NP_001292173
RefSeq Peptide - NP_997611
swissprot - A2AU35
swissprot - Q8BHL8
swissprot - D6REH2
Ensembl - ENSMUSG00000032869
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 psmf1ENSDARG00000022652Danio rerio
 PSMF1ENSGALG00000000259Gallus gallus
 PSMF1ENSG00000125818Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR013886  PI31 proteasome regulator, C-terminal
 IPR021625  PI31 proteasome regulator, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process ISS
 biological_processGO:1901799 negative regulation of proteasomal protein catabolic process ISS
 cellular_componentGO:0000502 proteasome complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISO
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0046982 protein heterodimerization activity ISO
 molecular_functionGO:0070628 proteasome binding ISS


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog on state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Ubiquitin-dependent degradation of Cyclin D1
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Interleukin-1 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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