ENSMUSG00000033420


Mus musculus

Features
Gene ID: ENSMUSG00000033420
  
Biological name :Antxr1
  
Synonyms : Anthrax toxin receptor 1 / Antxr1 / Q9CZ52
  
Possible biological names infered from orthology : Q9H6X2
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: D1
Gene start: 87133853
Gene end: 87335821
  
Corresponding Affymetrix probe sets: 10545974 (MoGene1.0st)   1431995_at (Mouse Genome 430 2.0 Array)   1451446_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000144853
Ensembl peptide - ENSMUSP00000145105
Ensembl peptide - ENSMUSP00000144911
Ensembl peptide - ENSMUSP00000045634
NCBI entrez gene - 69538     See in Manteia.
MGI - MGI:1916788
RefSeq - NM_054041
RefSeq - XM_006506564
RefSeq Peptide - NP_473382
swissprot - A0A0N4SV16
swissprot - Q9CZ52
swissprot - A0A0N4SUW7
Ensembl - ENSMUSG00000033420
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 antxr1aENSDARG00000025672Danio rerio
 antxr1bENSDARG00000074075Danio rerio
 ANTXR1ENSGALG00000030603Gallus gallus
 ANTXR1ENSG00000169604Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Antxr2 / Q6DFX2 / Anthrax toxin receptor 2 / P58335*ENSMUSG0000002933846
Antxrl / Q8BVM2 / Anthrax toxin receptor-like / A6NF34*ENSMUSG0000004744128
AC164099.2ENSMUSG0000011572622


Protein motifs (from Interpro)
Interpro ID Name
 IPR002035  von Willebrand factor, type A
 IPR008399  Anthrax toxin receptor, C-terminal
 IPR008400  Anthrax toxin receptor, extracellular
 IPR036465  von Willebrand factor A-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0022414 reproductive process IMP
 biological_processGO:0031532 actin cytoskeleton reorganization ISO
 biological_processGO:0034446 substrate adhesion-dependent cell spreading ISS
 biological_processGO:1901202 negative regulation of extracellular matrix assembly IMP
 biological_processGO:1905050 positive regulation of metallopeptidase activity IMP
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0009897 external side of plasma membrane ISO
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031258 lamellipodium membrane ISO
 cellular_componentGO:0031527 filopodium membrane ISS
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity ISS
 molecular_functionGO:0005518 collagen binding ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051015 actin filament binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000116 abnormal tooth development "anomalous formation of the teeth" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tg(CD2-Zbtb7b)C8Rbo/?,Themistm1Lov/Themistm1Lov
Genetic Background: involves: 129

 MP:0000120 malocclusion "perturbations in the normal patterned arrangement of the teeth or alignment of the jaw, resulting in the incorrect position of biting or chewing surfaces of the upper and lower teeth" [J:61509]
Show

Allelic Composition: Tg(CD2-Zbtb7b)C8Rbo/?,Themistm1Lov/Themistm1Lov
Genetic Background: involves: 129

 MP:0000133 abnormal long bone metaphysis morphology "malformed conical section of bone between the epiphysis and diaphysis of the long bones" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Tg(CD2-Zbtb7b)C8Rbo/?,Themistm1Lov/Themistm1Lov
Genetic Background: involves: 129

 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tg(CD2-Zbtb7b)C8Rbo/?,Themistm1Lov/Themistm1Lov
Genetic Background: involves: 129

 MP:0001126 abnormal ovary morphology "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Tg(CD2-Zbtb7b)C8Rbo/?,Themistm1Lov/Themistm1Lov
Genetic Background: involves: 129

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Pbx1tm1Mlc/Pbx1tm3.1Mlc,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0002835 abnormal cranial suture morphology "defects of the fibrous joint in the bones of the head" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:62161]
Show

Allelic Composition: Tg(CD2-Zbtb7b)C8Rbo/?,Themistm1Lov/Themistm1Lov
Genetic Background: involves: 129

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
Show

Allelic Composition: Tg(CD2-Zbtb7b)C8Rbo/?,Themistm1Lov/Themistm1Lov
Genetic Background: involves: 129

 MP:0003668 abnormal periodontal ligament morphology "any structural anomaly in the fibrous connective tissue that surrounds the root of a tooth, separating it from and attaching it to the alveolar bone; normally extends from the base of the gingival mucosa to the fundus of the bony socket, and its main function is to hold the tooth in its socket" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:66512]
Show

Allelic Composition: Tg(CD2-Zbtb7b)C8Rbo/?,Themistm1Lov/Themistm1Lov
Genetic Background: involves: 129

 MP:0008944 decreased sensitivity to induced cell death "increase in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pbx1tm1Mlc/Pbx1tm3.1Mlc,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Antxr1tm1.2Lepp/Antxr1tm1.2Lepp,Antxr2tm1.2Lepp/Antxr2tm1.2Lepp
Genetic Background: involves: 129 * C57BL/6

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Antxr1tm1.2Lepp/Antxr1tm1.2Lepp,Antxr2tm1.2Lepp/Antxr2tm1.2Lepp
Genetic Background: involves: 129 * C57BL/6

 MP:0010747 abnormal enamel organ morphology "any structural anomaly of the circumscribed mass of ectodermal cells which bud off from the dental lamina; it becomes cup-shaped and develops on its internal face the ameloblast layer of cells that produces the enamel cap of a developing tooth" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Tg(CD2-Zbtb7b)C8Rbo/?,Themistm1Lov/Themistm1Lov
Genetic Background: involves: 129

 MP:0013258 abnormal extracellular matrix morphology "any structural anomaly of the structure lying external to one or more cells, which provides structural support for cells or tissues; in mammals, the extracellular matrix is completely external to the cell " [GO:0031012]
Show

Allelic Composition: Tg(CD2-Zbtb7b)C8Rbo/?,Themistm1Lov/Themistm1Lov
Genetic Background: involves: 129

 MP:0030083 long upper incisors "increased length or overgrowth of the upper set of long teeth that are the most anterior and prominent in the jaw" [MGI:anna]
Show

Allelic Composition: Tg(CD2-Zbtb7b)C8Rbo/?,Themistm1Lov/Themistm1Lov
Genetic Background: involves: 129

 MP:0030541 misaligned incisors "abnormal alignment of the upper and lower incisor teeth, usually resulting in malocclusion; in gnawing rodents, where incisors are rootless and grow continually, signs of incisor malocclusion include uneven wear patterns, sloping of the cutting edges, fractured teeth, altered pigmentation, and obvious pathological overgrowth of the incisors" [HP:0011062, https://books.google.com/books?isbn=0323394302, PMID:19622764]
Show

Allelic Composition: Pbx1tm1Mlc/Pbx1tm3.1Mlc,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Antxr1tm1.2Bstc/Antxr1tm1.2Bstc
Genetic Background: B6.Cg-Antxr1tm1.2Bstc

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr