ENSMUSG00000033430


Mus musculus

Features
Gene ID: ENSMUSG00000033430
  
Biological name :Terf2ip
  
Synonyms : Q91VL8 / Telomeric repeat-binding factor 2-interacting protein 1 / Terf2ip
  
Possible biological names infered from orthology : Q9NYB0 / TERF2 interacting protein
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: E1
Gene start: 112011398
Gene end: 112020528
  
Corresponding Affymetrix probe sets: 10575619 (MoGene1.0st)   1419381_at (Mouse Genome 430 2.0 Array)   1426049_a_at (Mouse Genome 430 2.0 Array)   1456400_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000052170
NCBI entrez gene - 57321     See in Manteia.
MGI - MGI:1929871
RefSeq - NM_020584
RefSeq Peptide - NP_065609
swissprot - Q91VL8
Ensembl - ENSMUSG00000033430
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 terf2ipENSDARG00000103977Danio rerio
 TERF2IPENSGALG00000000903Gallus gallus
 Q9NYB0ENSG00000166848Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001357  BRCT domain
 IPR009057  Homeobox-like domain superfamily
 IPR015010  Rap1 Myb domain
 IPR021661  TRF2-interacting telomeric protein/Rap1, C-terminal
 IPR036420  BRCT domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000723 telomere maintenance IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated ISO
 biological_processGO:0010569 regulation of double-strand break repair via homologous recombination IMP
 biological_processGO:0010833 telomere maintenance via telomere lengthening IMP
 biological_processGO:0032204 regulation of telomere maintenance IEA
 biological_processGO:0032205 negative regulation of telomere maintenance IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0048239 negative regulation of DNA recombination at telomere IMP
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0070198 protein localization to chromosome, telomeric region IEA
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling IEA
 biological_processGO:1901985 positive regulation of protein acetylation IEA
 cellular_componentGO:0000781 chromosome, telomeric region ISO
 cellular_componentGO:0000783 nuclear telomere cap complex IEA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005635 nuclear envelope IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0030870 Mre11 complex IEA
 cellular_componentGO:0070187 shelterin complex IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019902 phosphatase binding IEA
 molecular_functionGO:0042162 telomeric DNA binding IEA
 molecular_functionGO:0098505 G-rich strand telomeric DNA binding IEA


Pathways (from Reactome)
Pathway description
Packaging Of Telomere Ends
DNA Damage/Telomere Stress Induced Senescence


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000010 abnormal abdominal fat pads "malformed or aberrant size of the encapsulated adipose tissue in the abdomen" [J:65146]
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Allelic Composition: Cdh23tm1.2Ugds/Cdh23tm1.2Ugds
Genetic Background: involves: 129S1/SvImJ * BALB/c * C57BL/6

 MP:0001188 hyperpigmentation "excess of pigment in any or all tissues or a part of a tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Cbln1tm1.2Mmsh/Cbln1tm1.2Mmsh
Genetic Background: involves: C57BL/6

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Cbln1tm1.2Mmsh/Cbln1tm1.2Mmsh
Genetic Background: involves: C57BL/6

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Cdh23tm1.2Ugds/Cdh23tm1.2Ugds
Genetic Background: involves: 129S1/SvImJ * BALB/c * C57BL/6

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdh23tm1.2Ugds/Cdh23tm1.2Ugds
Genetic Background: involves: 129S1/SvImJ * BALB/c * C57BL/6

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cdh23tm1.2Ugds/Cdh23tm1.2Ugds
Genetic Background: involves: 129S1/SvImJ * BALB/c * C57BL/6

 MP:0003155 abnormal telomere length "abnormal length of the terminal section of a chromosome which has a specialized structure and which is involved in chromosomal replication and stability; normal length is a few hundred base pairs" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Cbln1tm1.2Mmsh/Cbln1tm1.2Mmsh
Genetic Background: involves: C57BL/6

 MP:0003982 increased cholesterol level "greater than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdh23tm1.2Ugds/Cdh23tm1.2Ugds
Genetic Background: involves: 129S1/SvImJ * BALB/c * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cdh23tm1.2Ugds/Cdh23tm1.2Ugds
Genetic Background: involves: 129S1/SvImJ * BALB/c * C57BL/6

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cdh23tm1.2Ugds/Cdh23tm1.2Ugds
Genetic Background: involves: 129S1/SvImJ * BALB/c * C57BL/6

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdh23tm1.2Ugds/Cdh23tm1.2Ugds
Genetic Background: involves: 129S1/SvImJ * BALB/c * C57BL/6

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Cdh23tm1.2Ugds/Cdh23tm1.2Ugds
Genetic Background: involves: 129S1/SvImJ * BALB/c * C57BL/6

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp5se-52CoS/Bmp5se-52CoS
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0009286 increased abdominal fat pad weight "greater than average weight of the encapsulated adipose tissue in the abdomen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdh23tm1.2Ugds/Cdh23tm1.2Ugds
Genetic Background: involves: 129S1/SvImJ * BALB/c * C57BL/6

 MP:0009789 decreased susceptibility to bacterial infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmp5se-52CoS/Bmp5se-52CoS
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0010095 increased chromosomal stability "decrease in the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an reduced rate of loss of heterozygosity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Cbln1tm1.2Mmsh/Cbln1tm1.2Mmsh
Genetic Background: involves: C57BL/6

 MP:0010207 abnormal telomere morphology "any structural anomaly of the terminal repetitive DNA section of a chromosome which is involved in chromosomal replication and senescence, and which protects the end of the chromosome from deterioration" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cbln1tm1.2Mmsh/Cbln1tm1.2Mmsh
Genetic Background: involves: C57BL/6

Allelic Composition: Terf2iptm1.1Blas/Terf2iptm1.1Blas
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

 MP:0010934 increased subcutaneous adipose tissue amount "increase in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdh23tm1.2Ugds/Cdh23tm1.2Ugds
Genetic Background: involves: 129S1/SvImJ * BALB/c * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Bmp5se-52CoS/Bmp5se-52CoS
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0011117 abnormal susceptibility to weight gain "anomaly in body weight over time when compared to the average increase in weight on the same diet, with equal energy (calorie) intake" [MGI:csmith]
Show

Allelic Composition: Cdh23tm1.2Ugds/Cdh23tm1.2Ugds
Genetic Background: involves: 129S1/SvImJ * BALB/c * C57BL/6

 MP:0020411 increased abdominal adipose tissue amount "increase in amount of adipose tissue associated with internal organs" [MGI:anna]
Show

Allelic Composition: Cdh23tm1.2Ugds/Cdh23tm1.2Ugds
Genetic Background: involves: 129S1/SvImJ * BALB/c * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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