ENSMUSG00000033596


Mus musculus

Features
Gene ID: ENSMUSG00000033596
  
Biological name :Rfwd3
  
Synonyms : E3 ubiquitin-protein ligase RFWD3 / Q8CIK8 / Rfwd3
  
Possible biological names infered from orthology : Q6PCD5 / ring finger and WD repeat domain 3
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: E1
Gene start: 111270944
Gene end: 111300222
  
Corresponding Affymetrix probe sets: 10568461 (MoGene1.0st)   10581800 (MoGene1.0st)   1423882_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000043780
NCBI entrez gene - 234736     See in Manteia.
MGI - MGI:2384584
RefSeq - NM_146218
RefSeq Peptide - NP_666330
swissprot - Q8CIK8
Ensembl - ENSMUSG00000033596
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rfwd3ENSDARG00000087752Danio rerio
 ENSGALG00000036234Gallus gallus
 ENSGALG00000002755Gallus gallus
 RFWD3ENSG00000168411Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR036322  WD40-repeat-containing domain superfamily
 IPR037381  E3 ubiquitin-protein ligase RFWD3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0010212 response to ionizing radiation IEA
 biological_processGO:0016567 protein ubiquitination ISO
 biological_processGO:0031297 replication fork processing IEA
 biological_processGO:0031571 mitotic G1 DNA damage checkpoint IEA
 biological_processGO:0036297 interstrand cross-link repair ISS
 biological_processGO:2000001 regulation of DNA damage checkpoint IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0035861 site of double-strand break IEA
 cellular_componentGO:0090734 site of DNA damage IEA
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0097371 MDM2/MDM4 family protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Tg(MMTV-cre)1Mam/0,Tg(MMTV-PyVT)634Mul/0,Wisp3tm1.1Cgkl/Wisp3tm1.1Cgkl
Genetic Background: FVB/N-Wisp3tm1.1Cgkl Tg(MMTV-cre)1Mam Tg(MMTV-PyVT)634Mul

 MP:0001131 abnormal ovarian follicles "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
Show

Allelic Composition: Tg(MMTV-cre)1Mam/0,Tg(MMTV-PyVT)634Mul/0,Wisp3tm1.1Cgkl/Wisp3tm1.1Cgkl
Genetic Background: FVB/N-Wisp3tm1.1Cgkl Tg(MMTV-cre)1Mam Tg(MMTV-PyVT)634Mul

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Tg(MMTV-cre)1Mam/0,Tg(MMTV-PyVT)634Mul/0,Wisp3tm1.1Cgkl/Wisp3tm1.1Cgkl
Genetic Background: FVB/N-Wisp3tm1.1Cgkl Tg(MMTV-cre)1Mam Tg(MMTV-PyVT)634Mul

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Tg(MMTV-cre)1Mam/0,Tg(MMTV-PyVT)634Mul/0,Wisp3tm1.1Cgkl/Wisp3tm1.1Cgkl
Genetic Background: FVB/N-Wisp3tm1.1Cgkl Tg(MMTV-cre)1Mam Tg(MMTV-PyVT)634Mul

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tg(MMTV-cre)1Mam/0,Tg(MMTV-PyVT)634Mul/0,Wisp3tm1.1Cgkl/Wisp3tm1.1Cgkl
Genetic Background: FVB/N-Wisp3tm1.1Cgkl Tg(MMTV-cre)1Mam Tg(MMTV-PyVT)634Mul

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Tg(MMTV-cre)1Mam/0,Tg(MMTV-PyVT)634Mul/0,Wisp3tm1.1Cgkl/Wisp3tm1.1Cgkl
Genetic Background: FVB/N-Wisp3tm1.1Cgkl Tg(MMTV-cre)1Mam Tg(MMTV-PyVT)634Mul

 MP:0003205 testicular atrophy "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Tg(MMTV-cre)1Mam/0,Tg(MMTV-PyVT)634Mul/0,Wisp3tm1.1Cgkl/Wisp3tm1.1Cgkl
Genetic Background: FVB/N-Wisp3tm1.1Cgkl Tg(MMTV-cre)1Mam Tg(MMTV-PyVT)634Mul

 MP:0004833 ovary atrophy "wasting of the ovary due to injury or disease resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(MMTV-cre)1Mam/0,Tg(MMTV-PyVT)634Mul/0,Wisp3tm1.1Cgkl/Wisp3tm1.1Cgkl
Genetic Background: FVB/N-Wisp3tm1.1Cgkl Tg(MMTV-cre)1Mam Tg(MMTV-PyVT)634Mul

 MP:0014040 increased cellular sensitivity to DNA damaging agents "greater incidence of cell death following exposure to agents that cause DNA damage" [MGI:csmith]
Show

Allelic Composition: Tg(MMTV-cre)1Mam/0,Tg(MMTV-PyVT)634Mul/0,Wisp3tm1.1Cgkl/Wisp3tm1.1Cgkl
Genetic Background: FVB/N-Wisp3tm1.1Cgkl Tg(MMTV-cre)1Mam Tg(MMTV-PyVT)634Mul

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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