Manteia - Molecule gene

ENSMUSG00000033615

Mus musculus

Features

Gene ID:	ENSMUSG00000033615

Biological name :	Cplx1

Synonyms :	Complexin-1 / Cplx1 / P63040

Possible biological names infered from orthology :	O14810

Species:	Mus musculus

Chr. number:	5
Strand:	-1
Band:	F
Gene start:	108518554
Gene end:	108550024

Corresponding Affymetrix probe sets:	10532180 (MoGene1.0st) 1417746_at (Mouse Genome 430 2.0 Array) 1417747_at (Mouse Genome 430 2.0 Array) 1448832_a_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000118118 Ensembl peptide - ENSMUSP00000038502 NCBI entrez gene - 12889 See in Manteia. MGI - MGI:104727 RefSeq - NM_007756 RefSeq Peptide - NP_031782 swissprot - D3YZ72 swissprot - P63040 Ensembl - ENSMUSG00000033615

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
cplx1	ENSDARG00000111920	Danio rerio
cplx2l	ENSDARG00000018997	Danio rerio
CPLX1	ENSGALG00000015332	Gallus gallus
CPLX1	ENSG00000168993	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Cplx2 / P84086 / Complexin-2 / Q6PUV4*	ENSMUSG00000025867	84

Protein motifs (from Interpro)

Interpro ID	Name
IPR008849	Synaphin

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006836	neurotransmitter transport	IEA
biological_process	GO:0006887	exocytosis	IEA
biological_process	GO:0016079	synaptic vesicle exocytosis	IMP
biological_process	GO:0030073	insulin secretion	IMP
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	IEA
cellular_component	GO:0030425	dendrite	IEA
cellular_component	GO:0031201	SNARE complex	IDA
cellular_component	GO:0043025	neuronal cell body	IEA
cellular_component	GO:0043195	terminal bouton	IEA
cellular_component	GO:0045202	synapse	IEA
cellular_component	GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex	IEA
cellular_component	GO:0098793	presynapse	IEA
molecular_function	GO:0000149	SNARE binding	IEA
molecular_function	GO:0005326	neurotransmitter transporter activity	IMP
molecular_function	GO:0017075	syntaxin-1 binding	IEA
molecular_function	GO:0019905	syntaxin binding	IEA

Pathways (from Reactome)

Pathway description

Serotonin Neurotransmitter Release Cycle

Norepinephrine Neurotransmitter Release Cycle

Glutamate Neurotransmitter Release Cycle

Dopamine Neurotransmitter Release Cycle

Acetylcholine Neurotransmitter Release Cycle

GABA synthesis, release, reuptake and degradation

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000242	impaired fertilization	"defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Thrb^tm4Few/Thrb^tm4Few Genetic Background: involves: 129 * C57BL/6
MP:0000951	sporadic seizures	"occasional seizures occuring at irregular intervals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Thrb^tm4Few/Thrb^tm4Few Genetic Background: involves: 129 * C57BL/6
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Thrb^tm4Few/Thrb^tm4Few Genetic Background: involves: 129 * C57BL/6
MP:0001393	ataxia	"inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]	Show Allelic Composition: Thrb^tm4Few/Thrb^tm4Few Genetic Background: involves: 129 * C57BL/6
MP:0001900	impaired synaptic plasticity	"decreased or inability of the nervous system to change its reactivity as a result of successive activations " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Thrb^tm4Few/Thrb^tm4Few Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Cplx1^tm1Rmnd/Cplx1^tm1Rmnd,Cplx2^tm1Rmnd/Cplx2^tm1Rmnd,Cplx3^tm1Rmnd/Cplx3^tm1Rmnd Genetic Background: Not Specified
MP:0001924	infertility	"inability to produce live offspring" [J:47225]	Show Allelic Composition: Thrb^tm4Few/Thrb^tm4Few Genetic Background: involves: 129 * C57BL/6
MP:0001925	male infertility	"inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Thrb^tm4Few/Thrb^tm4Few Genetic Background: involves: 129 * C57BL/6
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Thrb^tm4Few/Thrb^tm4Few Genetic Background: involves: 129 * C57BL/6
MP:0002206	abnormal CNS synaptic transmission	"defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Thrb^tm4Few/Thrb^tm4Few Genetic Background: involves: 129 * C57BL/6
MP:0002566	abnormal sexual interaction	"altered initiation, failure of initiation or incomplete mating behavior" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Thrb^tm4Few/Thrb^tm4Few Genetic Background: involves: 129 * C57BL/6
MP:0002675	asthenozoospermia	"loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Thrb^tm4Few/Thrb^tm4Few Genetic Background: involves: 129 * C57BL/6
MP:0002910	abnormal excitatory postsynaptic currents	"defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Thrb^tm4Few/Thrb^tm4Few Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Cplx1^tm1Rmnd/Cplx1^tm1Rmnd,Cplx2^tm1Rmnd/Cplx2^tm1Rmnd Genetic Background: Not Specified Allelic Composition: Cplx1^tm1Rmnd/Cplx1^tm1Rmnd,Cplx2^tm1Rmnd/Cplx2^tm1Rmnd,Cplx3^tm1Rmnd/Cplx3^tm1Rmnd Genetic Background: Not Specified
MP:0002945	abnormal inhibitory postsynaptic currents	"defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Cplx1^tm1Rmnd/Cplx1^tm1Rmnd,Cplx2^tm1Rmnd/Cplx2^tm1Rmnd Genetic Background: Not Specified Allelic Composition: Cplx1^tm1Rmnd/Cplx1^tm1Rmnd,Cplx2^tm1Rmnd/Cplx2^tm1Rmnd,Cplx3^tm1Rmnd/Cplx3^tm1Rmnd Genetic Background: Not Specified
MP:0004542	impaired acrosome reaction	"abnormality in the cellular exocytosis that allows sperm to penetrate the zona pellucida of ovulated eggs" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thrb^tm4Few/Thrb^tm4Few Genetic Background: involves: 129 * C57BL/6
MP:0004753	abnormal miniature excitatory postsynaptic currents	"defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thrb^tm4Few/Thrb^tm4Few Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Cplx1^tm1Rmnd/Cplx1^tm1Rmnd,Cplx2^tm1Rmnd/Cplx2^tm1Rmnd Genetic Background: Not Specified Allelic Composition: Cplx1^tm1Rmnd/Cplx1^tm1Rmnd,Cplx2^tm1Rmnd/Cplx2^tm1Rmnd,Cplx3^tm1Rmnd/Cplx3^tm1Rmnd Genetic Background: Not Specified
MP:0004807	abnormal paired pulse inhibition	"defects in the supressive response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of inhibition of neurotransmitter release at the second stimulus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thrb^tm4Few/Thrb^tm4Few Genetic Background: involves: 129 * C57BL/6
MP:0004811	abnormal neuron physiology	"anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]	Show Allelic Composition: Thrb^tm4Few/Thrb^tm4Few Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Cplx1^tm1Rmnd/Cplx1^tm1Rmnd,Cplx2^tm1Rmnd/Cplx2^tm1Rmnd Genetic Background: Not Specified Allelic Composition: Cplx1^tm1Rmnd/Cplx1^tm1Rmnd,Cplx2^tm1Rmnd/Cplx2^tm1Rmnd,Cplx3^tm1Rmnd/Cplx3^tm1Rmnd Genetic Background: Not Specified
MP:0005445	abnormal neurotransmitter release	"aberration in the secretion of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Thrb^tm4Few/Thrb^tm4Few Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Cplx1^tm1Rmnd/Cplx1^tm1Rmnd,Cplx2^tm1Rmnd/Cplx2^tm1Rmnd,Cplx3^tm1Rmnd/Cplx3^tm1Rmnd Genetic Background: Not Specified
MP:0006335	abnormal hearing electrophysiology	"anomaly in auditory function as it relates to electrical phenomena" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thrb^tm4Few/Thrb^tm4Few Genetic Background: involves: 129 * C57BL/6
MP:0010746	abnormal pre-Botzinger complex physiology	"any functional anomaly of the group of interneurons within the medulla oblongata s ventral respiratory group that are important for the generation of ventilatory (inspiratory) rhythmogenesis" [PMID:18826652]	Show Allelic Composition: Cplx1^tm1Rmnd/Cplx1^tm1Rmnd,Cplx2^tm1Rmnd/Cplx2^tm1Rmnd Genetic Background: Not Specified Allelic Composition: Cplx1^tm1Rmnd/Cplx1^tm1Rmnd,Cplx2^tm1Rmnd/Cplx2^tm1Rmnd,Cplx3^tm1Rmnd/Cplx3^tm1Rmnd Genetic Background: Not Specified
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Cplx1^tm1Rmnd/Cplx1^tm1Rmnd,Cplx2^tm1Rmnd/Cplx2^tm1Rmnd Genetic Background: Not Specified Allelic Composition: Cplx1^tm1Rmnd/Cplx1^tm1Rmnd,Cplx2^tm1Rmnd/Cplx2^tm1Rmnd,Cplx3^tm1Rmnd/Cplx3^tm1Rmnd Genetic Background: Not Specified
MP:0011966	abnormal auditory brainstem response waveform shape	"any anomaly in the characteristic pattern of electrical activity recording of a series of vertex positive waves generated by neurons in the ascending auditory system, that can be recorded from scalp electrograms by using computer-averaged responses to short tone bursts" [MGI:csmith]	Show Allelic Composition: Thrb^tm4Few/Thrb^tm4Few Genetic Background: involves: 129 * C57BL/6
MP:0011967	increased or absent threshold for auditory brainstem response	"increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]	Show Allelic Composition: Thrb^tm4Few/Thrb^tm4Few Genetic Background: involves: 129 * C57BL/6

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr