| MP:0000352 | decreased cell proliferation | "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Jag1Ndr/Jag1+
Genetic Background: involves: C3H
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| MP:0000479 | abnormal intestinal cell | "anomalous structure or development of the cells comprising the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Jag1Ndr/Jag1+
Genetic Background: involves: C3H
|
| MP:0001698 | reduced embryo size | "smaller proportions of embryo compared to littermates" [J:61790] |
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Allelic Composition: Jag1Ndr/Jag1+
Genetic Background: involves: C3H
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| MP:0003059 | decreased insulin secretion | "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission] |
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Allelic Composition: Trhrtm1Bau/Trhrtm1Bau
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0003119 | abnormal digestive system development | "dysmorphology of the organ system that converts ingested food to nutrients and energy" [smb:Susan M. Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Jag1Ndr/Jag1+
Genetic Background: involves: C3H
|
| MP:0003339 | decreased number of pancreatic beta cells | "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Trhrtm1Bau/Trhrtm1Bau
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0003562 | abnormal beta cell physiology | "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Trhrtm1Bau/Trhrtm1Bau
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0003984 | embryonic growth retardation | "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Jag1Ndr/Jag1+
Genetic Background: involves: C3H
|
| MP:0005215 | abnormal islet of Langerhans morphology | "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Trhrtm1Bau/Trhrtm1Bau
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0005217 | abnormal pancreatic beta cell morphology | "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Trhrtm1Bau/Trhrtm1Bau
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0005290 | decreased oxygen consumption | "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Trhrtm1Bau/Trhrtm1Bau
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0005293 | impaired glucose tolerance | "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Trhrtm1Bau/Trhrtm1Bau
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0005621 | abnormal cell physiology | "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator] |
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Allelic Composition: Jag1Ndr/Jag1+
Genetic Background: involves: C3H
|
| MP:0006035 | abnormal mitochondrial morphology | "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Trhrtm1Bau/Trhrtm1Bau
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0006036 | abnormal mitochondrial physiology | |
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Allelic Composition: Trhrtm1Bau/Trhrtm1Bau
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0008108 | abnormal small intestinal villus morphology | "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Jag1Ndr/Jag1+
Genetic Background: involves: C3H
|
| MP:0008109 | abnormal small intestinal microvillus morphology | "any structural anomaly of the additional extensions of the villi of the small intestine which protrude from the apical surface of the epithelial cells lining the villi; the microvilli increase the absorptive surface area of the small intestine by approximately 600-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Jag1Ndr/Jag1+
Genetic Background: involves: C3H
|
| MP:0009114 | decreased pancreatic beta cell mass | "reduced total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Trhrtm1Bau/Trhrtm1Bau
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0010157 | abnormal small intestinal crypt cell proliferation | "anomaly in the ability of the cells that make up the tubular intestinal glands found in the mucosal membranes of the small intestine to undergo expansion by cell division" [MGI:jbubier "Jason Bubier, Mouse Genome Informatics Curator"] |
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Allelic Composition: Jag1Ndr/Jag1+
Genetic Background: involves: C3H
|
| MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Jag1Ndr/Jag1+
Genetic Background: involves: C3H
|
| MP:0011090 | partial perinatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
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Allelic Composition: Jag1Ndr/Jag1+
Genetic Background: involves: C3H
|
| MP:0011096 | complete embryonic lethality before somite formation | "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith] |
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Allelic Composition: Jag1Ndr/Jag1+
Genetic Background: involves: C3H
|
| MP:0011101 | partial prenatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Jag1Ndr/Jag1+
Genetic Background: involves: C3H
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| MP:0011198 | absent proamniotic cavity | "absence of the cavity of the developing embryo that is formed within the epiblast tissue prior to the closing of the proamniotic canal by the amniotic folds" [ISBN:0-12-402035-6] |
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Allelic Composition: Jag1Ndr/Jag1+
Genetic Background: involves: C3H
|
| MP:0011628 | increased mitochondria number | "greater than normal number of the cellular organelles responsible for energy production" [MGI:csmith] |
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Allelic Composition: Trhrtm1Bau/Trhrtm1Bau
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0011635 | abnormal mitochondrial crista morphology | "Any of the inward folds of the mitochondrial inner membrane; crista number, extent, and shape differ in mitochondria from different tissues and organisms; crista appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found; the shape can vary with the respiratory state of the mitochondria" [GO:0030061] |
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Allelic Composition: Trhrtm1Bau/Trhrtm1Bau
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0011637 | abnormal mitochondrial matrix morphology | "any structural anomaly of the gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion, and contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation" [GO:0005759] |
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Allelic Composition: Trhrtm1Bau/Trhrtm1Bau
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0011820 | decreased pancreatic beta cell proliferation | "reduction in the ability of the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas to undergo expansion by cell division" [CL:0000169] |
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Allelic Composition: Trhrtm1Bau/Trhrtm1Bau
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0012114 | absent inner cell mass proliferation | |
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Allelic Composition: Jag1Ndr/Jag1+
Genetic Background: involves: C3H
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| MP:0013504 | increased embryonic tissue cell apoptosis | "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith] |
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Allelic Composition: Jag1Ndr/Jag1+
Genetic Background: involves: C3H
|
| MP:0014079 | decreased small intestinal villus number | "fewer than normal numbers of the tiny hair-like projections which protrude from the inside of the small intestine and contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall" [MGI:Anna, PMID:16679353] |
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Allelic Composition: Jag1Ndr/Jag1+
Genetic Background: involves: C3H
|
| MP:0014082 | decreased small intestinal villus height | "decreased height of the tiny hair-like projections which protrude from the inside of the small intestine and contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; usually accompanied by crypt elongation or hyperplasia" [MGI:Anna, PMID:16679353] |
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Allelic Composition: Jag1Ndr/Jag1+
Genetic Background: involves: C3H
|
