ENSMUSG00000033880


Mus musculus

Features
Gene ID: ENSMUSG00000033880
  
Biological name :Lgals3bp
  
Synonyms : Galectin-3-binding protein / Lgals3bp / Q07797
  
Possible biological names infered from orthology : Q08380
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E2
Gene start: 118392751
Gene end: 118402092
  
Corresponding Affymetrix probe sets: 10393573 (MoGene1.0st)   1448380_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120846
Ensembl peptide - ENSMUSP00000121024
Ensembl peptide - ENSMUSP00000035579
Ensembl peptide - ENSMUSP00000101897
NCBI entrez gene - 19039     See in Manteia.
MGI - MGI:99554
RefSeq - NM_011150
RefSeq Peptide - NP_035280
swissprot - E9Q5X5
swissprot - F6VRP8
swissprot - Q07797
Ensembl - ENSMUSG00000033880
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lgals3bpaENSDARG00000037805Danio rerio
 lgals3bpbENSDARG00000040528Danio rerio
 zgc:112492ENSDARG00000076848Danio rerio
 Q08380ENSG00000108679Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Btbd17 / Q9DB72 / BTB/POZ domain-containing protein 17 / A6NE02* / BTB domain containing 17*ENSMUSG0000000020219


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR001190  SRCR domain
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR011705  BTB/Kelch-associated
 IPR017448  SRCR-like domain
 IPR036772  SRCR-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0007155 cell adhesion IEA
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0005044 scavenger receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Platelet degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Myoz2tm1Eno/Myoz2tm1Eno,Tg(Myh6-Ppp3ca)37Eno/0
Genetic Background: involves: 129 * C57BL/6J

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Myoz2tm1Eno/Myoz2tm1Eno,Tg(Myh6-Ppp3ca)37Eno/0
Genetic Background: involves: 129 * C57BL/6J

 MP:0008617 increased circulating interleukin-12 level "increase in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Myoz2tm1Eno/Myoz2tm1Eno,Tg(Myh6-Ppp3ca)37Eno/0
Genetic Background: involves: 129 * C57BL/6J

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Myoz2tm1Eno/Myoz2tm1Eno,Tg(Myh6-Ppp3ca)37Eno/0
Genetic Background: involves: 129 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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