ENSMUSG00000033952


Mus musculus

Features
Gene ID: ENSMUSG00000033952
  
Biological name :Aspm
  
Synonyms : Abnormal spindle-like microcephaly-associated protein homolog / Aspm / Q8CJ27
  
Possible biological names infered from orthology : abnormal spindle microtubule assembly / Q8IZT6
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: E4
Gene start: 139454772
Gene end: 139494091
  
Corresponding Affymetrix probe sets: 10350392 (MoGene1.0st)   1422814_at (Mouse Genome 430 2.0 Array)   1441520_at (Mouse Genome 430 2.0 Array)   1452459_at (Mouse Genome 430 2.0 Array)   1458560_at (Mouse Genome 430 2.0 Array)   1458873_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000059159
Ensembl peptide - ENSMUSP00000142880
NCBI entrez gene - 12316     See in Manteia.
MGI - MGI:1334448
RefSeq - NM_009791
RefSeq Peptide - NP_033921
swissprot - Q8CJ27
Ensembl - ENSMUSG00000033952
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aspmENSDARG00000103754Danio rerio
 ASPMENSGALG00000032398Gallus gallus
 ASPMENSG00000066279Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR001715  Calponin homology domain
 IPR011989  Armadillo-like helical
 IPR013783  Immunoglobulin-like fold
 IPR016024  Armadillo-type fold
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR029955  Abnormal spindle-like microcephaly-associated protein
 IPR031549  Abnormal spindle-like microcephaly-associated protein, ASH domain
 IPR036872  CH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0002052 positive regulation of neuroblast proliferation IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007051 spindle organization ISO
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0007420 brain development IMP
 biological_processGO:0008584 male gonad development IMP
 biological_processGO:0021873 forebrain neuroblast division IMP
 biological_processGO:0021987 cerebral cortex development IMP
 biological_processGO:0045665 negative regulation of neuron differentiation IMP
 biological_processGO:0045769 negative regulation of asymmetric cell division IMP
 biological_processGO:0048477 oogenesis IMP
 biological_processGO:0048589 developmental growth IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051445 regulation of meiotic cell cycle IMP
 biological_processGO:0051653 spindle localization IEA
 biological_processGO:0051661 maintenance of centrosome location IMP
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IGI
 biological_processGO:0090306 spindle assembly involved in meiosis IMP
 biological_processGO:0097150 neuronal stem cell population maintenance IMP
 cellular_componentGO:0000922 spindle pole IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IDA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0036449 microtubule minus-end IEA
 cellular_componentGO:0072687 meiotic spindle IDA
 cellular_componentGO:0097431 mitotic spindle pole IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005516 calmodulin binding IDA
 molecular_functionGO:0019901 protein kinase binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Clcn4tm1Tjj/Clcn4tm1Tjj,Clcn5tm6.1Tjj/Y,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: AspmGt(AA0137)Wtsi/AspmGt(AA0137)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6JOlaHsd

Allelic Composition: Aspmtm1(cre)Mrc/Aspmtm1(cre)Mrc
Genetic Background: Not Specified

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: AspmGt(AA0137)Wtsi/AspmGt(AA0137)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6JOlaHsd

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
Show

Allelic Composition: Aspmtm1(cre)Mrc/Aspmtm1(cre)Mrc
Genetic Background: Not Specified

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Tnfrsf1atm1Mak/Tnfrsf1a+
Genetic Background: involves: 129S2/SvPas

 MP:0001152 Leydig cell hyperplasia "increased number of interstitial cells of the seminiferous tubules that secrete testosterone" [J:45065]
Show

Allelic Composition: Tnfrsf1atm1Mak/Tnfrsf1a+
Genetic Background: involves: 129S2/SvPas

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Tnfrsf1atm1Mak/Tnfrsf1a+
Genetic Background: involves: 129S2/SvPas

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: AspmGt(AA0137)Wtsi/AspmGt(AA0137)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6JOlaHsd

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
Show

Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Clcn4tm1Tjj/Clcn4tm1Tjj,Clcn5tm6.1Tjj/Y,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: AspmGt(AA0137)Wtsi/AspmGt(AA0137)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6JOlaHsd

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Clcn4tm1Tjj/Clcn4tm1Tjj,Clcn5tm6.1Tjj/Y,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: AspmGt(AA0137)Wtsi/AspmGt(AA0137)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6JOlaHsd

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Clcn4tm1Tjj/Clcn4tm1Tjj,Clcn5tm6.1Tjj/Y,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: AspmGt(AA0137)Wtsi/AspmGt(AA0137)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6JOlaHsd

Allelic Composition: Aspmtm1.2Kxi/Aspmtm1.2Kxi
Genetic Background: involves: C57BL * C57BL/6J * DBA

Allelic Composition: Aspmtm1(cre)Mrc/Aspmtm1(cre)Mrc
Genetic Background: Not Specified

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aspmtm1(cre)Mrc/Aspmtm1(cre)Mrc
Genetic Background: Not Specified

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Clcn4tm1Tjj/Clcn4tm1Tjj,Clcn5tm6.1Tjj/Y,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: AspmGt(AA0137)Wtsi/AspmGt(AA0137)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6JOlaHsd

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Clcn4tm1Tjj/Clcn4tm1Tjj,Clcn5tm6.1Tjj/Y,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: AspmGt(AA0137)Wtsi/AspmGt(AA0137)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6JOlaHsd

Allelic Composition: Aspmtm1.2Kxi/Aspmtm1.2Kxi
Genetic Background: involves: C57BL * C57BL/6J * DBA

 MP:0002784 abnormal Sertoli cell morphology "malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aspmtm1.2Kxi/Aspmtm1.2Kxi
Genetic Background: involves: C57BL * C57BL/6J * DBA

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Aspmtm1(cre)Mrc/Aspmtm1(cre)Mrc
Genetic Background: Not Specified

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0003989 abnormal barrel cortex morphology "malformation of the discrete functional units of the somatosensory cortex that processes tactile information derived from the vibrissae" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Aspmtm1.2Kxi/Aspmtm1.2Kxi
Genetic Background: involves: C57BL * C57BL/6J * DBA

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clcn4tm1Tjj/Clcn4tm1Tjj,Clcn5tm6.1Tjj/Y,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: AspmGt(AA0137)Wtsi/AspmGt(AA0137)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6JOlaHsd

 MP:0004856 decreased ovary weight "reduction in the average weight of the female reproductive gland containing the germ cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clcn4tm1Tjj/Clcn4tm1Tjj,Clcn5tm6.1Tjj/Y,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: AspmGt(AA0137)Wtsi/AspmGt(AA0137)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6JOlaHsd

 MP:0004981 decreased neuronal precursor cell number "reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aspmtm1(cre)Mrc/Aspmtm1(cre)Mrc
Genetic Background: Not Specified

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
Show

Allelic Composition: Aspmtm1.2Kxi/Aspmtm1.2Kxi
Genetic Background: involves: C57BL * C57BL/6J * DBA

Allelic Composition: Aspmtm1(cre)Mrc/Aspmtm1(cre)Mrc
Genetic Background: Not Specified

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aspmtm1.2Kxi/Aspmtm1.2Kxi
Genetic Background: involves: C57BL * C57BL/6J * DBA

 MP:0008540 abnormal cerebrum morphology "any structural anomaly of the largest part of the brain, derived from the telencephalon, and is composed of a right and a left hemisphere each which contains an outer cerebral cortex and a subcortical basal ganglia; cerebral functions include sensorimotor, emotional, and intellectual activities" [MESH:A08.186.211.730.885.287]
Show

Allelic Composition: Aspmtm1.2Kxi/Aspmtm1.2Kxi
Genetic Background: involves: C57BL * C57BL/6J * DBA

 MP:0008547 abnormal neocortex morphology "any structural anomaly of the larger part of the mammalian cerebral cortex, distinguished from the allocortex by being composed of a larger number of nerve cells arranged in six layers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.885.213.420]
Show

Allelic Composition: Clcn4tm1Tjj/Clcn4tm1Tjj,Clcn5tm6.1Tjj/Y,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: AspmGt(AA0137)Wtsi/AspmGt(AA0137)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6JOlaHsd

 MP:0009235 small sperm head "reduced size of the head segment of the sperm cell" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clcn4tm1Tjj/Clcn4tm1Tjj,Clcn5tm6.1Tjj/Y,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: AspmGt(AA0137)Wtsi/AspmGt(AA0137)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6JOlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr