ENSMUSG00000034786


Mus musculus

Features
Gene ID: ENSMUSG00000034786
  
Biological name :Gpsm3
  
Synonyms : G-protein signalling modulator 3 (AGS3-like, C. elegans) / Gpsm3 / Q3U1Z5
  
Possible biological names infered from orthology : G protein signaling modulator 3 / Q9Y4H4
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: B1
Gene start: 34589806
Gene end: 34591754
  
Corresponding Affymetrix probe sets: 10444386 (MoGene1.0st)   1418396_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000045911
Ensembl peptide - ENSMUSP00000134130
Ensembl peptide - ENSMUSP00000134586
NCBI entrez gene - 106512     See in Manteia.
MGI - MGI:2146785
RefSeq - NM_134116
RefSeq Peptide - NP_598877
swissprot - Q3U1Z5
swissprot - G3UYL4
swissprot - G3UZQ1
swissprot - Q0VGT5
Ensembl - ENSMUSG00000034786
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GPSM3ENSG00000213654Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003109  GoLoco motif


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002690 positive regulation of leukocyte chemotaxis IMP
 biological_processGO:0050729 positive regulation of inflammatory response IMP
 biological_processGO:0050790 regulation of catalytic activity IEA
 biological_processGO:1900017 positive regulation of cytokine production involved in inflammatory response IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IDA
 molecular_functionGO:0030695 GTPase regulator activity IEA


Pathways (from Reactome)
Pathway description
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Epn1tm1.1Wami/Epn1tm1.1Wami,Epn2tm1Ocr/Epn2tm1Ocr,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Gna11tm1b(EUCOMM)Wtsi/Gna11tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Gna11tm1b(EUCOMM)Wtsi/H

 MP:0001102 small superior vagus ganglion "reduced size of the upper ganglion of the vagus nerve located at the jugular foramen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
Show

Allelic Composition: Gna11tm1b(EUCOMM)Wtsi/Gna11tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Gna11tm1b(EUCOMM)Wtsi/H

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Epn1tm1.1Wami/Epn1tm1.1Wami,Epn2tm1Ocr/Epn2tm1Ocr,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
Show

Allelic Composition: Epn1tm1.1Wami/Epn1tm1.1Wami,Epn2tm1Ocr/Epn2tm1Ocr,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
Show

Allelic Composition: Epn1tm1.1Wami/Epn1tm1.1Wami,Epn2tm1Ocr/Epn2tm1Ocr,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0011968 decreased threshold for auditory brainstem response "reduction in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system" [MGI:csmith]
Show

Allelic Composition: Gna11tm1b(EUCOMM)Wtsi/Gna11tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Gna11tm1b(EUCOMM)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr