ENSMUSG00000034833


Mus musculus

Features
Gene ID: ENSMUSG00000034833
  
Biological name :Tespa1
  
Synonyms : Protein TESPA1 / Q3U132 / Tespa1
  
Possible biological names infered from orthology : A2RU30 / thymocyte expressed, positive selection associated 1
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: D3
Gene start: 130322870
Gene end: 130364111
  
Corresponding Affymetrix probe sets: 10367532 (MoGene1.0st)   1428959_at (Mouse Genome 430 2.0 Array)   1439179_a_at (Mouse Genome 430 2.0 Array)   1439981_at (Mouse Genome 430 2.0 Array)   1444051_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000047284
Ensembl peptide - ENSMUSP00000151338
Ensembl peptide - ENSMUSP00000152009
NCBI entrez gene - 67596     See in Manteia.
MGI - MGI:1914846
RefSeq - NM_183264
RefSeq - XM_006514006
RefSeq Peptide - NP_899087
swissprot - Q3U132
Ensembl - ENSMUSG00000034833
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tespa1ENSDARG00000053311Danio rerio
 ENSGALG00000037826Gallus gallus
 A2RU30ENSG00000135426Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ssfa2 / Q922B9 / Sperm-specific antigen 2 homolog / P28290* / sperm specific antigen 2*ENSMUSG0000002700725
Q14B48 / Ccdc129 / Coiled-coil domain-containing protein 129 / Q6ZRS4* / coiled-coil domain containing 129*ENSMUSG0000003797316


Protein motifs (from Interpro)
Interpro ID Name
 IPR026647  Protein TESPA1
 IPR029325  KRAP, ITPR-interacting domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010387 COP9 signalosome assembly IMP
 biological_processGO:0033089 positive regulation of T cell differentiation in thymus IMP
 biological_processGO:0050862 positive regulation of T cell receptor signaling pathway IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0008180 COP9 signalosome ISS
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005102 signaling receptor binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
Show

Allelic Composition: Kcnj11tm1Sse/Kcnj11tm1Sse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcnj11tm1Sse/Kcnj11tm1Sse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tespa1tm1Lrgl/Tespa1tm1Lrgl,Tg(TcraTcrb)1100Mjb/0
Genetic Background: B6.Cg-Tespa1tm1Lrgl Tg(TcraTcrb)1100Mjb

Allelic Composition: Tespa1tm1Lrgl/Tespa1tm1Lrgl,Tg(TcraTcrb)425Cbn/0
Genetic Background: B6.Cg-Tespa1tm1Lrgl Tg(TcraTcrb)425Cbn

 MP:0003790 absent CD4+8- cells "lack of the set of single-positive T cells that express CD4 on their surface" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tespa1tm1Lrgl/Tespa1tm1Lrgl
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kcnj11tm1Sse/Kcnj11tm1Sse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005010 abnormal CD8+ T cell morphology/development "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Tespa1tm1Lrgl/Tespa1tm1Lrgl
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kcnj11tm1Sse/Kcnj11tm1Sse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Kcnj11tm1Sse/Kcnj11tm1Sse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kcnj11tm1Sse/Kcnj11tm1Sse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008049 increased memory T cell number "greater number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kcnj11tm1Sse/Kcnj11tm1Sse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kcnj11tm1Sse/Kcnj11tm1Sse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tespa1tm1Lrgl/Tespa1tm1Lrgl,Tg(TcraTcrb)1100Mjb/0
Genetic Background: B6.Cg-Tespa1tm1Lrgl Tg(TcraTcrb)1100Mjb

Allelic Composition: Tespa1tm1Lrgl/Tespa1tm1Lrgl,Tg(TcraTcrb)425Cbn/0
Genetic Background: B6.Cg-Tespa1tm1Lrgl Tg(TcraTcrb)425Cbn

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kcnj11tm1Sse/Kcnj11tm1Sse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tespa1tm1Lrgl/Tespa1tm1Lrgl,Tg(TcraTcrb)1100Mjb/0
Genetic Background: B6.Cg-Tespa1tm1Lrgl Tg(TcraTcrb)1100Mjb

Allelic Composition: Tespa1tm1Lrgl/Tespa1tm1Lrgl,Tg(TcraTcrb)425Cbn/0
Genetic Background: B6.Cg-Tespa1tm1Lrgl Tg(TcraTcrb)425Cbn

Allelic Composition: Tespa1tm1Lrgl/Tespa1tm1Lrgl,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2J

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tespa1tm1Lrgl/Tespa1tm1Lrgl
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Kcnj11tm1Sse/Kcnj11tm1Sse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Kcnj11tm1Sse/Kcnj11tm1Sse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013588 small thymus medulla "decreased size of the inner area of thymus lobules" [MGI:Anna]
Show

Allelic Composition: Kcnj11tm1Sse/Kcnj11tm1Sse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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