ENSMUSG00000034990


Mus musculus

Features
Gene ID: ENSMUSG00000034990
  
Biological name :Otoa
  
Synonyms : Otoa / Otoancorin / Q8K561
  
Possible biological names infered from orthology : Q7RTW8
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F2
Gene start: 121081650
Gene end: 121163097
  
Corresponding Affymetrix probe sets: 10557076 (MoGene1.0st)   1428037_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000044177
Ensembl peptide - ENSMUSP00000146993
Ensembl peptide - ENSMUSP00000146799
Ensembl peptide - ENSMUSP00000133005
Ensembl peptide - ENSMUSP00000132951
Ensembl peptide - ENSMUSP00000125928
NCBI entrez gene - 246190     See in Manteia.
MGI - MGI:2149209
RefSeq - XM_017322267
RefSeq - NM_139310
RefSeq Peptide - NP_647471
swissprot - A0A140LIF2
swissprot - E9PWK6
swissprot - A0A140LIX3
swissprot - Q8K561
swissprot - E9PVT3
swissprot - E9Q5L1
Ensembl - ENSMUSG00000034990
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 OTOAENSGALG00000007070Gallus gallus
 OTOAENSG00000155719Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Strc / Q8VIM6 / Stereocilin / Q7RTU9*ENSMUSG0000003349818


Protein motifs (from Interpro)
Interpro ID Name
 IPR026663  Otoancorin
 IPR026664  Stereocilin-related


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007160 cell-matrix adhesion IMP
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0019226 transmission of nerve impulse IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
Post-translational modification: synthesis of GPI-anchored proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003149 abnormal tectorial membrane morphology "malformation, malfunction or absence of the overlaying membrane of cochlear duct, an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells; sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair cell membrane potential, transducing sound into electrical signals" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:77634]
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Allelic Composition: Rabl2mot/Rabl2mot
Genetic Background: C57BL/6(CBA)-Rabl2mot

 MP:0003150 detached tectorial membrane "tectorial membrane is abnormally detached from the cochlear epithelium or spiral limbus" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:77634]
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Allelic Composition: Rabl2mot/Rabl2mot
Genetic Background: C57BL/6(CBA)-Rabl2mot

 MP:0004415 abnormal cochlear nerve compound action potential "anomaly in the combined potentials resulting from activation of the auditory division of the eighth cranial nerve; these potentials represent the summed activity of multiple cochlear afferent fibers discharging synchronously and thus assess the combined functional state of OHCs, IHCs, and their primary afferent innervation" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Rabl2mot/Rabl2mot
Genetic Background: C57BL/6(CBA)-Rabl2mot

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rabl2mot/Rabl2mot
Genetic Background: C57BL/6(CBA)-Rabl2mot

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nampttm1.1(KOMP)Vlcg/Nampttm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Nampttm1.1(KOMP)Vlcg/Ucd

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Nampttm1.1(KOMP)Vlcg/Nampttm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Nampttm1.1(KOMP)Vlcg/Ucd

 MP:0013962 absent Hensen stripe "absence of the dark, nonstriated, V-shaped band (ridge) that is normally found on the underside of the tectorial membrane (TM) in the basal region of the cochlea, from which fine gelatinous trabeculae extend to fix the TM to the border cells, i.e. cells directly adjacent to the inner phalangeal cells" [ISBN:3662026767, PMID:25080593]
Show

Allelic Composition: Rabl2mot/Rabl2mot
Genetic Background: C57BL/6(CBA)-Rabl2mot

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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