ENSMUSG00000035165


Mus musculus

Features
Gene ID: ENSMUSG00000035165
  
Biological name :Kcne3
  
Synonyms : Kcne3 / Potassium voltage-gated channel subfamily E member 3 / Q9WTW2
  
Possible biological names infered from orthology : potassium voltage-gated channel subfamily E regulatory subunit 3 / Q9Y6H6
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: E2
Gene start: 100176502
Gene end: 100184869
  
Corresponding Affymetrix probe sets: 10555297 (MoGene1.0st)   1418499_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000039353
Ensembl peptide - ENSMUSP00000130019
Ensembl peptide - ENSMUSP00000136415
Ensembl peptide - ENSMUSP00000136616
Ensembl peptide - ENSMUSP00000146583
Ensembl peptide - ENSMUSP00000147047
Ensembl peptide - ENSMUSP00000147151
NCBI entrez gene - 57442     See in Manteia.
MGI - MGI:1891124
RefSeq - XM_017322388
RefSeq - NM_001190869
RefSeq - NM_001190870
RefSeq - NM_001190871
RefSeq - NM_001190950
RefSeq - NM_020574
RefSeq - XM_006508058
RefSeq - XM_006508059
RefSeq - XM_006508062
RefSeq Peptide - NP_001177798
RefSeq Peptide - NP_001177800
RefSeq Peptide - NP_001177879
RefSeq Peptide - NP_065599
RefSeq Peptide - NP_001177799
swissprot - Q545H9
swissprot - Q9WTW2
Ensembl - ENSMUSG00000035165
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 KCNE3ENSGALG00000022696Gallus gallus
 KCNE3ENSG00000175538Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000369  Potassium channel, voltage-dependent, beta subunit, KCNE
 IPR005426  Potassium channel, voltage-dependent, beta subunit, KCNE3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0043266 regulation of potassium ion transport IEA
 biological_processGO:0060306 regulation of membrane repolarization IBA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 biological_processGO:0086091 regulation of heart rate by cardiac conduction ISO
 biological_processGO:1901379 regulation of potassium ion transmembrane transport IBA
 biological_processGO:1901387 positive regulation of voltage-gated calcium channel activity IEA
 biological_processGO:1902260 negative regulation of delayed rectifier potassium channel activity ISO
 biological_processGO:1903765 negative regulation of potassium ion export across plasma membrane ISO
 biological_processGO:1903817 negative regulation of voltage-gated potassium channel activity ISO
 biological_processGO:1905025 negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0008076 voltage-gated potassium channel complex IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030425 dendrite ISS
 cellular_componentGO:0031982 vesicle ISO
 cellular_componentGO:0032809 neuronal cell body membrane ISO
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043204 perikaryon ISO
 cellular_componentGO:0045121 membrane raft ISO
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005249 voltage-gated potassium channel activity IEA
 molecular_functionGO:0005267 potassium channel activity ISS
 molecular_functionGO:0015459 potassium channel regulator activity ISO
 molecular_functionGO:0044325 ion channel binding IEA


Pathways (from Reactome)
Pathway description
Phase 3 - rapid repolarisation
Phase 2 - plateau phase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Atp1a3tm1.1Kwk/Atp1a3+
Genetic Background: B6JJcl.Cg-Atp1a3tm1.1Kwk

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Atp1a3tm1.1Kwk/Atp1a3+
Genetic Background: B6JJcl.Cg-Atp1a3tm1.1Kwk

 MP:0000639 abnormal adrenal gland morphology "malformed endocrine glands located above the kidney responsible for hormone and epinephrine secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61190]
Show

Allelic Composition: Atp1a3tm1.1Kwk/Atp1a3+
Genetic Background: B6JJcl.Cg-Atp1a3tm1.1Kwk

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Atp1a3tm1.1Kwk/Atp1a3+
Genetic Background: B6JJcl.Cg-Atp1a3tm1.1Kwk

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Irf4m1Btlr/Irf4m1Btlr
Genetic Background: C57BL/6J-Irf4m1Btlr

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Atp1a3tm1.1Kwk/Atp1a3+
Genetic Background: B6JJcl.Cg-Atp1a3tm1.1Kwk

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Irf4m1Btlr/Irf4m1Btlr
Genetic Background: C57BL/6J-Irf4m1Btlr

 MP:0002666 increased circulating aldosterone level "increased blood concentration of this hormone, secreted by the adrenal cortex, in the bloodstream; regulates sodium conservation and potassium secretion in the distal renal tubule" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Atp1a3tm1.1Kwk/Atp1a3+
Genetic Background: B6JJcl.Cg-Atp1a3tm1.1Kwk

 MP:0003233 prolonged QT interval "increase in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time" [J:93197, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Atp1a3tm1.1Kwk/Atp1a3+
Genetic Background: B6JJcl.Cg-Atp1a3tm1.1Kwk

 MP:0003285 gastric hypertrophy "increase in the bulk size of the stomach due to cell enlargement or accumulation of fluids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Kcne2tm1Gwab/Kcne2tm1Gwab
Genetic Background: involves: 129S4/SvJae

 MP:0003883 enlarged stomach "increased size of the stomach" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcne2tm1Gwab/Kcne2tm1Gwab,Kcne3tm1Gwab/Kcne3tm1Gwab
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Kcne2tm1Gwab/Kcne2+,Kcne3tm1Gwab/Kcne3tm1Gwab
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Atp1a3tm1.1Kwk/Atp1a3+
Genetic Background: B6JJcl.Cg-Atp1a3tm1.1Kwk

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rhojtm1.1Auem/Rhojtm1.1Auem,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: C57BL/6 * CBA/JNCrlj

 MP:0006335 abnormal hearing electrophysiology "anomaly in auditory function as it relates to electrical phenomena" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhojtm1.1Auem/Rhojtm1.1Auem,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: C57BL/6 * CBA/JNCrlj

 MP:0008003 achlorhydria "absence of hydrochloric acid in the gastric secretions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kcne2tm1Gwab/Kcne2tm1Gwab,Kcne3tm1Gwab/Kcne3tm1Gwab
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0008006 increased stomach pH "change in the function of the secretory and buffer systems of the stomach that control the relative acidity or alkalinity, such that the acidity is decreased, as indicated by the decreased concentration of hydrogen ion" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kcne2tm1Gwab/Kcne2tm1Gwab,Kcne3tm1Gwab/Kcne3tm1Gwab
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Irf4m1Btlr/Irf4m1Btlr
Genetic Background: C57BL/6J-Irf4m1Btlr

 MP:0008950 ventricular tachycardia "paroxysmal rapid beating of the heart originating in an ectopic focus in the heart ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Atp1a3tm1.1Kwk/Atp1a3+
Genetic Background: B6JJcl.Cg-Atp1a3tm1.1Kwk

 MP:0010155 abnormal intestine physiology "any functional anomaly of the digestive tube passing from the stomach to the anus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Irf4m1Btlr/Irf4m1Btlr
Genetic Background: C57BL/6J-Irf4m1Btlr

 MP:0010505 abnormal T wave "any anomaly in the T wave which is normally caused by the repolarization (or recovery) of the ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atp1a3tm1.1Kwk/Atp1a3+
Genetic Background: B6JJcl.Cg-Atp1a3tm1.1Kwk

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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