ENSMUSG00000035472


Mus musculus

Features
Gene ID: ENSMUSG00000035472
  
Biological name :Slc25a21
  
Synonyms : Q8BZ09 / Slc25a21 / solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21
  
Possible biological names infered from orthology : Q9BQT8 / solute carrier family 25 member 21
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: C1
Gene start: 56712634
Gene end: 57197472
  
Corresponding Affymetrix probe sets: 10400483 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000151751
Ensembl peptide - ENSMUSP00000039289
Ensembl peptide - ENSMUSP00000106308
NCBI entrez gene - 217593     See in Manteia.
MGI - MGI:2445059
RefSeq - NM_001167976
RefSeq - NM_172577
RefSeq Peptide - NP_001161448
RefSeq Peptide - NP_766165
swissprot - B6CI26
swissprot - Q8BZ09
Ensembl - ENSMUSG00000035472
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc25a21ENSDARG00000060564Danio rerio
 SLC25A21ENSGALG00000010117Gallus gallus
 Q9BQT8ENSG00000183032Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR018108  Mitochondrial substrate/solute carrier
 IPR023395  Mitochondrial carrier domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006835 dicarboxylic acid transport IBA
 biological_processGO:0006839 mitochondrial transport IBA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005743 mitochondrial inner membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005310 dicarboxylic acid transmembrane transporter activity IBA


Pathways (from Reactome)
Pathway description
Lysine catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc16a2tm1a(KOMP)Wtsi/Slc16a2tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Slc16a2tm1a(KOMP)Wtsi/Wtsi

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc24a5tm1b(KOMP)Mbp/Slc24a5tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Slc24a5tm1b(KOMP)Mbp/J

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc16a2tm1a(KOMP)Wtsi/Slc16a2tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Slc16a2tm1a(KOMP)Wtsi/Wtsi

 MP:0000443 abnormal snout morphology "anomalous structure or development of the anterior facial part of the muzzle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc16a2tm1a(KOMP)Wtsi/Slc16a2tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Slc16a2tm1a(KOMP)Wtsi/Wtsi

 MP:0000458 abnormal mandible morphology "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Slc16a2tm1a(KOMP)Wtsi/Slc16a2tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Slc16a2tm1a(KOMP)Wtsi/Wtsi

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Slc16a2tm1a(KOMP)Wtsi/Slc16a2tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Slc16a2tm1a(KOMP)Wtsi/Wtsi

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Slc16a2tm1a(KOMP)Wtsi/Slc16a2tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Slc16a2tm1a(KOMP)Wtsi/Wtsi

 MP:0002100 abnormal tooth morphology "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc16a2tm1a(KOMP)Wtsi/Slc16a2tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Slc16a2tm1a(KOMP)Wtsi/Wtsi

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc24a5tm1b(KOMP)Mbp/Slc24a5tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Slc24a5tm1b(KOMP)Mbp/J

 MP:0002932 abnormal joint "defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Slc16a2tm1a(KOMP)Wtsi/Slc16a2tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Slc16a2tm1a(KOMP)Wtsi/Wtsi

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Slc16a2tm1a(KOMP)Wtsi/Slc16a2tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Slc16a2tm1a(KOMP)Wtsi/Wtsi

 MP:0005358 abnormal incisor morphology "structural defect of the long pointed teeth; most anterior and prominent in the jaw" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85574]
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Allelic Composition: Slc16a2tm1a(KOMP)Wtsi/Slc16a2tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Slc16a2tm1a(KOMP)Wtsi/Wtsi

 MP:0005562 decreased mean corpuscular hemoglobin "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc24a5tm1b(KOMP)Mbp/Slc24a5tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Slc24a5tm1b(KOMP)Mbp/J

 MP:0005628 decreased circulating potassium level "less than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]
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Allelic Composition: Slc16a2tm1a(KOMP)Wtsi/Slc16a2tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Slc16a2tm1a(KOMP)Wtsi/Wtsi

 MP:0005632 decreased circulating aspartate transaminase level "less than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Slc16a2tm1a(KOMP)Wtsi/Slc16a2tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Slc16a2tm1a(KOMP)Wtsi/Wtsi

 MP:0006358 absent pinna reflex "complete failure to respond to an auditory stimulus by a characteristic ear twitch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc16a2tm1a(KOMP)Wtsi/Slc16a2tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Slc16a2tm1a(KOMP)Wtsi/Wtsi

 MP:0008040 decreased NK T cell number "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Slc24a5tm1b(KOMP)Mbp/Slc24a5tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Slc24a5tm1b(KOMP)Mbp/J

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc16a2tm1a(KOMP)Wtsi/Slc16a2tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Slc16a2tm1a(KOMP)Wtsi/Wtsi

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc16a2tm1a(KOMP)Wtsi/Slc16a2tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Slc16a2tm1a(KOMP)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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