ENSMUSG00000035517


Mus musculus

Features
Gene ID: ENSMUSG00000035517
  
Biological name :Tdrd7
  
Synonyms : Mus musculus tudor domain containing 7 (Tdrd7), transcript variant 3, mRNA. / Q8K1H1 / Tdrd7
  
Possible biological names infered from orthology : Q8NHU6 / tudor domain containing 7
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: B1
Gene start: 45965334
Gene end: 46034761
  
Corresponding Affymetrix probe sets: 10504672 (MoGene1.0st)   1426716_at (Mouse Genome 430 2.0 Array)   1459216_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099993
Ensembl peptide - ENSMUSP00000103406
NCBI entrez gene - 100121     See in Manteia.
MGI - MGI:2140279
RefSeq - XM_006537519
RefSeq - NM_001290475
RefSeq - NM_001355189
RefSeq - NM_146142
RefSeq - XM_006537517
RefSeq - XM_006537518
RefSeq Peptide - NP_666254
RefSeq Peptide - NP_001277404
RefSeq Peptide - NP_001342118
swissprot - Q8K1H1
swissprot - A0A0A0MQD1
Ensembl - ENSMUSG00000035517
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 E7FDW8ENSDARG00000077523Danio rerio
 tdrd7aENSDARG00000032808Danio rerio
 TDRD7ENSGALG00000012350Gallus gallus
 TDRD7ENSG00000196116Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002999  Tudor domain
 IPR025605  OST-HTH/LOTUS domain
 IPR035437  SNase-like, OB-fold superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002089 lens morphogenesis in camera-type eye ISO
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007281 germ cell development IDA
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0010608 posttranscriptional regulation of gene expression ISS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0070306 lens fiber cell differentiation ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0033391 chromatoid body IDA
 cellular_componentGO:0035770 ribonucleoprotein granule ISS
 cellular_componentGO:0043186 P granule IDA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0047485 protein N-terminus binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Lgals12tm1Ftl/Lgals12tm1Ftl
Genetic Background: B6.129-Lgals12tm1Ftl

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
Show

Allelic Composition: Tdrd7nmf166/Tdrd7nmf166
Genetic Background: involves: C3H * C57BL/6J

Allelic Composition: Tdrd7tm1.1Chum/Tdrd7tm1.1Chum
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Tdrd6tm1Chum/Tdrd6tm1Chum,Tdrd7tm1.1Chum/Tdrd7tm1.1Chum
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * ICR

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
Show

Allelic Composition: Ttnmdm/Ttnmdm
Genetic Background: involves: C57BL/6J

Allelic Composition: Tdrd7nmf166/Tdrd7nmf166
Genetic Background: involves: C3H * C57BL/6J

 MP:0001322 abnormal iris morphology "structural anomaly of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tdrd7nmf166/Tdrd7nmf166
Genetic Background: involves: C3H * C57BL/6J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Tdrd7nmf166/Tdrd7nmf166
Genetic Background: involves: C3H * C57BL/6J

Allelic Composition: Tdrd7tm1.1Chum/Tdrd7tm1.1Chum
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Tdrd6tm1Chum/Tdrd6tm1Chum,Tdrd7tm1.1Chum/Tdrd7tm1.1Chum
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0002840 abnormal lens fibers morphology "structural anomaly of the elongated cells of the crystalline lens of the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tdrd7nmf166/Tdrd7nmf166
Genetic Background: involves: C3H * C57BL/6J

 MP:0003698 abnormal male reproductive system physiology "anomaly in the function of the male organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tdrd7tm1.1Chum/Tdrd7tm1.1Chum
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005205 abnormal eye anterior chamber "anomaly of the space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ttnmdm/Ttnmdm
Genetic Background: involves: C57BL/6J

 MP:0005258 ocular hypertension "abnormal elevation of the intraocular pressure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tdrd7nmf166/Tdrd7nmf166
Genetic Background: involves: C3H * C57BL/6J

 MP:0005515 uveitis "inflammation of part or all of the uvea, the middle (vascular) tunic of the eye, and commonly involving the other tunics (sclera and cornea, and the retina)" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Tdrd7nmf166/Tdrd7nmf166
Genetic Background: involves: C3H * C57BL/6J

 MP:0006219 optic nerve degeneration "retrogressive pathologic change of the optic nerve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tdrd7tm1.1Chum/Tdrd7tm1.1Chum
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0006222 optic neuropathy "damage of the optic nerve due to a blockage of its blood supply, to nutritional deficiencies, or to toxins" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tdrd7nmf166/Tdrd7nmf166
Genetic Background: involves: C3H * C57BL/6J

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tdrd7tm1.1Chum/Tdrd7tm1.1Chum
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008841 ruptured lens capsule "a break or tear in the elastic, clear, membrane-like structure, that is outer most layer of the lens" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tdrd7nmf166/Tdrd7nmf166
Genetic Background: involves: C3H * C57BL/6J

 MP:0009829 enlarged eye anterior chamber "increased size of the space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens" [MESH:A09.371.060.067, MGI:mberry "Melissa Berry, Genetics Resources Curator"]
Show

Allelic Composition: Tdrd7nmf166/Tdrd7nmf166
Genetic Background: involves: C3H * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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