ENSMUSG00000035673


Mus musculus

Features
Gene ID: ENSMUSG00000035673
  
Biological name :Sbno2
  
Synonyms : Protein strawberry notch homolog 2 / Q7TNB8 / Sbno2
  
Possible biological names infered from orthology : Q9Y2G9 / strawberry notch homolog 2
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C1
Gene start: 80056992
Gene end: 80105571
  
Corresponding Affymetrix probe sets: 10370721 (MoGene1.0st)   1439349_at (Mouse Genome 430 2.0 Array)   1441840_x_at (Mouse Genome 430 2.0 Array)   1443721_x_at (Mouse Genome 430 2.0 Array)   1458308_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151854
Ensembl peptide - ENSMUSP00000151449
Ensembl peptide - ENSMUSP00000151590
Ensembl peptide - ENSMUSP00000151835
Ensembl peptide - ENSMUSP00000041635
NCBI entrez gene - 216161     See in Manteia.
MGI - MGI:2448490
RefSeq - XM_017313893
RefSeq - XM_006513496
RefSeq - XM_006513497
RefSeq - XM_017313890
RefSeq - XM_017313891
RefSeq - XM_017313892
RefSeq - NM_183426
RefSeq - XM_006513492
RefSeq - XM_006513493
RefSeq - XM_006513494
RefSeq - XM_006513495
RefSeq Peptide - NP_906271
swissprot - A0A1W2P7W9
swissprot - A0A1W2P7W8
swissprot - A0A1W2P6Y8
swissprot - Q7TNB8
Ensembl - ENSMUSG00000035673
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sbno2aENSDARG00000098801Danio rerio
 si:ch73-63e15.2ENSDARG00000016188Danio rerio
 SBNO2ENSGALG00000037522Gallus gallus
 SBNO2ENSG00000064932Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sbno1 / strawberry notch 1 / A3KN83* / strawberry notch homolog 1*ENSMUSG0000003809546


Protein motifs (from Interpro)
Interpro ID Name
 IPR026741  Protein strawberry notch
 IPR026937  Strawberry notch, helicase C domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030410  Protein strawberry notch homologue 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IEA
 biological_processGO:0002281 macrophage activation involved in immune response ISO
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030282 bone mineralization IMP
 biological_processGO:0030316 osteoclast differentiation IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0050727 regulation of inflammatory response ISO
 biological_processGO:0061430 bone trabecula morphogenesis IMP
 biological_processGO:0071222 cellular response to lipopolysaccharide IDA
 biological_processGO:0071348 cellular response to interleukin-11 IDA
 biological_processGO:0071354 cellular response to interleukin-6 ISO
 biological_processGO:0072674 multinuclear osteoclast differentiation IMP
 biological_processGO:0072675 osteoclast fusion IMP
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IDA
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000067 osteopetrosis "excessive formation of dense trabecular bone and excessive calcified cartilage formation; may lead to anemia and extramedullary hematopoiesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Myh9tm1.1Dash/Myh9tm1.1Dash
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Myh9tm1.1Dash/Myh9tm1.1Dash
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
Show

Allelic Composition: Myh9tm1.1Dash/Myh9tm1.1Dash
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myh9tm1.1Dash/Myh9tm1.1Dash
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myh9tm1.1Dash/Myh9tm1.1Dash
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0004982 abnormal osteoclast morphology "any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myh9tm1.1Dash/Myh9tm1.1Dash
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0005605 increased bone mass "an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Myh9tm1.1Dash/Myh9tm1.1Dash
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
Show

Allelic Composition: Myh9tm1.1Dash/Myh9tm1.1Dash
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0009347 increased cancellous bone thickness "thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myh9tm1.1Dash/Myh9tm1.1Dash
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0010867 abnormal bone trabecula morphology "any structural anomaly of the network of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myh9tm1.1Dash/Myh9tm1.1Dash
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0010868 increased bone trabecula number "increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myh9tm1.1Dash/Myh9tm1.1Dash
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0010875 increased bone volume "increased amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myh9tm1.1Dash/Myh9tm1.1Dash
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Myh9tm1.1Dash/Myh9tm1.1Dash
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0011711 decreased osteoblast differentiation 
Show

Allelic Composition: Myh9tm1.1Dash/Myh9tm1.1Dash
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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