ENSMUSG00000035735


Mus musculus

Features
Gene ID: ENSMUSG00000035735
  
Biological name :Dagla
  
Synonyms : Dagla / Q6WQJ1 / Sn1-specific diacylglycerol lipase alpha
  
Possible biological names infered from orthology : diacylglycerol lipase alpha / Q9Y4D2
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 10245265
Gene end: 10304877
  
Corresponding Affymetrix probe sets: 10465943 (MoGene1.0st)   1455448_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000046358
Ensembl peptide - ENSMUSP00000138702
NCBI entrez gene - 269060     See in Manteia.
MGI - MGI:2677061
RefSeq - XM_017318213
RefSeq - NM_198114
RefSeq - XM_006527114
RefSeq Peptide - NP_932782
swissprot - S4R2M3
swissprot - Q6WQJ1
Ensembl - ENSMUSG00000035735
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 daglaENSDARG00000062956Danio rerio
 DAGLAENSGALG00000036492Gallus gallus
 DAGLAENSG00000134780Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Daglb / Q91WC9 / Sn1-specific diacylglycerol lipase beta / Q8NCG7* / diacylglycerol lipase beta*ENSMUSG0000003920622


Protein motifs (from Interpro)
Interpro ID Name
 IPR002921  Fungal lipase-like domain
 IPR029058  Alpha/Beta hydrolase fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0007216 G-protein coupled glutamate receptor signaling pathway IMP
 biological_processGO:0007405 neuroblast proliferation IMP
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0019369 arachidonic acid metabolic process IEA
 biological_processGO:0022008 neurogenesis IMP
 biological_processGO:0042136 neurotransmitter biosynthetic process IEA
 biological_processGO:0046340 diacylglycerol catabolic process IEA
 biological_processGO:0071926 endocannabinoid signaling pathway IMP
 biological_processGO:0098921 retrograde trans-synaptic signaling by endocannabinoid IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043196 varicosity IDA
 cellular_componentGO:0045211 postsynaptic membrane IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Arachidonate production from DAG


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Daam2tm1b(KOMP)Wtsi/Daam2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Daam2tm1b(KOMP)Wtsi/Wtsi

 MP:0000601 small liver "reduced size of the liver" [J:23170]
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Allelic Composition: Daam2tm1b(KOMP)Wtsi/Daam2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Daam2tm1b(KOMP)Wtsi/Wtsi

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Daam2tm1b(KOMP)Wtsi/Daam2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Daam2tm1b(KOMP)Wtsi/Wtsi

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Daam2tm1b(KOMP)Wtsi/Daam2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Daam2tm1b(KOMP)Wtsi/Wtsi

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Daam2tm1b(KOMP)Wtsi/Daam2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Daam2tm1b(KOMP)Wtsi/Wtsi

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Daam2tm1b(KOMP)Wtsi/Daam2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Daam2tm1b(KOMP)Wtsi/Wtsi

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: DaglbGt(OST195261)Lex/DaglbGt(OST195261)Lex
Genetic Background: B6.129S5-DaglbGt(OST195261)Lex

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: DaglbGt(OST195261)Lex/DaglbGt(OST195261)Lex
Genetic Background: B6.129S5-DaglbGt(OST195261)Lex

 MP:0001899 absent long term depression "lack of the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [Principles of Neural Science:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Plxnb2tm1a(EUCOMM)Wtsi/Plxnb2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6-Plxnb2tm1a(EUCOMM)Wtsi

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Daam2tm1b(KOMP)Wtsi/Daam2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Daam2tm1b(KOMP)Wtsi/Wtsi

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
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Allelic Composition: Daam2tm1b(KOMP)Wtsi/Daam2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Daam2tm1b(KOMP)Wtsi/Wtsi

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Myo1etm1Flv/Myo1etm1.1Flv,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002691 small stomach "reduced size of the stomach" [J:77398, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Daam2tm1b(KOMP)Wtsi/Daam2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Daam2tm1b(KOMP)Wtsi/Wtsi

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm2.1Glo/Mdm4+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: DaglbGt(OST195261)Lex/DaglbGt(OST195261)Lex
Genetic Background: B6.129S5-DaglbGt(OST195261)Lex

Allelic Composition: Daglatm1.1Kano/Daglatm1.1Kano
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

 MP:0003465 increased single cell response threshold "increase in the value at which a stimulus first elicits a recordable response" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Myo1etm1Flv/Myo1etm1.1Flv,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0003632 abnormal nervous system morphology 
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Allelic Composition: Daglatm1.1Kano/Daglatm1.1Kano
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

Allelic Composition: DaglaGt(OST288027)Lex/DaglaGt(OST288027)Lex
Genetic Background: involves: 129S5/SvEvBrd

Allelic Composition: DaglaGt(OST288027)Lex/DaglaGt(OST288027)Lex,DaglbGt(OST195261)Lex/DaglbGt(OST195261)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0003641 small lung "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]
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Allelic Composition: Daam2tm1b(KOMP)Wtsi/Daam2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Daam2tm1b(KOMP)Wtsi/Wtsi

 MP:0003795 abnormal bone structure 
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Allelic Composition: Daam2tm1b(KOMP)Wtsi/Daam2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Daam2tm1b(KOMP)Wtsi/Wtsi

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Daam2tm1b(KOMP)Wtsi/Daam2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Daam2tm1b(KOMP)Wtsi/Wtsi

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Daam2tm1b(KOMP)Wtsi/Daam2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Daam2tm1b(KOMP)Wtsi/Wtsi

 MP:0004981 decreased neuronal precursor cell number "reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: DaglbGt(OST195261)Lex/DaglbGt(OST195261)Lex
Genetic Background: B6.129S5-DaglbGt(OST195261)Lex

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Daam2tm1b(KOMP)Wtsi/Daam2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Daam2tm1b(KOMP)Wtsi/Wtsi

 MP:0009967 abnormal neuron proliferation "any anomaly in the ability of a neuron to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: DaglbGt(OST195261)Lex/DaglbGt(OST195261)Lex
Genetic Background: B6.129S5-DaglbGt(OST195261)Lex

Allelic Composition: Daglatm1Pado/Daglatm1Pado
Genetic Background: C57BL/6-Daglatm1Pado

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Daam2tm1b(KOMP)Wtsi/Daam2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Daam2tm1b(KOMP)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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