ENSMUSG00000035936


Mus musculus

Features
Gene ID: ENSMUSG00000035936
  
Biological name :Aldh5a1
  
Synonyms : Aldh5a1 / aldhehyde dehydrogenase family 5, subfamily A1 / Q8BWF0
  
Possible biological names infered from orthology : aldehyde dehydrogenase 5 family member A1 / P51649
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: A3.1
Gene start: 24907579
Gene end: 24937661
  
Corresponding Affymetrix probe sets: 10408335 (MoGene1.0st)   1453065_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000040591
NCBI entrez gene - 214579     See in Manteia.
MGI - MGI:2441982
RefSeq - NM_172532
RefSeq Peptide - NP_766120
swissprot - B2RS41
swissprot - Q8BWF0
Ensembl - ENSMUSG00000035936
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aldh5a1ENSDARG00000076544Danio rerio
 ALDH5A1ENSGALG00000032544Gallus gallus
 P51649ENSG00000112294Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Aldh16a1 / aldehyde dehydrogenase 16 family, member A1 / Q8IZ83*ENSMUSG0000000783324


Protein motifs (from Interpro)
Interpro ID Name
 IPR010102  Succinate semialdehyde dehydrogenase
 IPR015590  Aldehyde dehydrogenase domain
 IPR016160  Aldehyde dehydrogenase, cysteine active site
 IPR016161  Aldehyde/histidinol dehydrogenase
 IPR016162  Aldehyde dehydrogenase, N-terminal
 IPR029510  Aldehyde dehydrogenase, glutamic acid active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006006 glucose metabolic process IMP
 biological_processGO:0006083 acetate metabolic process IMP
 biological_processGO:0006105 succinate metabolic process IMP
 biological_processGO:0006536 glutamate metabolic process IMP
 biological_processGO:0006540 glutamate decarboxylation to succinate IBA
 biological_processGO:0006541 glutamine metabolic process IMP
 biological_processGO:0006650 glycerophospholipid metabolic process IMP
 biological_processGO:0006678 glucosylceramide metabolic process IMP
 biological_processGO:0006681 galactosylceramide metabolic process IMP
 biological_processGO:0006749 glutathione metabolic process IMP
 biological_processGO:0007417 central nervous system development IBA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009448 gamma-aminobutyric acid metabolic process IMP
 biological_processGO:0009450 gamma-aminobutyric acid catabolic process ISO
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0022904 respiratory electron transport chain IMP
 biological_processGO:0042135 neurotransmitter catabolic process IMP
 biological_processGO:0046459 short-chain fatty acid metabolic process IMP
 biological_processGO:0051289 protein homotetramerization ISO
 biological_processGO:0055114 oxidation-reduction process ISS
 cellular_componentGO:0005739 mitochondrion ISO
 molecular_functionGO:0004777 succinate-semialdehyde dehydrogenase (NAD+) activity ISO
 molecular_functionGO:0009013 succinate-semialdehyde dehydrogenase [NAD(P)+] activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
 molecular_functionGO:0051287 NAD binding IBA


Pathways (from Reactome)
Pathway description
Degradation of GABA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000243 myoclonus "involuntary shock-like contractions, variable in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscles; generally due to a central nervous system lesion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Zeb1Tw/Zeb1Tw
Genetic Background: Not Specified

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Zeb1Tw/Zeb1Tw
Genetic Background: Not Specified

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Zeb1Tw/Zeb1Tw
Genetic Background: Not Specified

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Zeb1Tw/Zeb1Tw
Genetic Background: Not Specified

 MP:0002826 tonic seizures "increased number or decreased threshold for the induction of a seizure characterized by muscle rigidity" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Zeb1Tw/Zeb1Tw
Genetic Background: Not Specified

 MP:0003216 absence seizures "impairment of consciousness without convulsions associated with widespread bilaterally synchronous spike-and-wave discharges (SWDs) in the electroencephalogram (EEG)" [RGD:Rat Genome Database submission]
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Allelic Composition: Zeb1Tw/Zeb1Tw
Genetic Background: Not Specified

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Zeb1Tw/Zeb1Tw
Genetic Background: Not Specified

 MP:0005266 abnormal metabolism "anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Zeb1Tw/Zeb1Tw
Genetic Background: Not Specified

 MP:0005332 abnormal amino acid level "aberrant concentration of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Zeb1Tw/Zeb1Tw
Genetic Background: Not Specified

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zeb1Tw/Zeb1Tw
Genetic Background: Not Specified

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Zeb1Tw/Zeb1Tw
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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