ENSMUSG00000035992


Mus musculus

Features
Gene ID: ENSMUSG00000035992
  
Biological name :Fnip1
  
Synonyms : Fnip1 / Folliculin-interacting protein 1 / Q68FD7
  
Possible biological names infered from orthology : Q8TF40
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B1.3
Gene start: 54438199
Gene end: 54518235
  
Corresponding Affymetrix probe sets: 10376144 (MoGene1.0st)   1419924_at (Mouse Genome 430 2.0 Array)   1434405_at (Mouse Genome 430 2.0 Array)   1449668_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000049026
Ensembl peptide - ENSMUSP00000121399
NCBI entrez gene - 216742     See in Manteia.
MGI - MGI:2444668
RefSeq - XM_006532849
RefSeq - NM_173753
RefSeq - XM_006532847
RefSeq - XM_006532848
RefSeq Peptide - NP_776114
swissprot - F6RJ64
swissprot - Q68FD7
Ensembl - ENSMUSG00000035992
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fnip1ENSDARG00000102171Danio rerio
 FNIP1ENSGALG00000017462Gallus gallus
 FNIP1ENSG00000217128Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fnip2 / Q80TD3 / Folliculin-interacting protein 2 / Q9P278*ENSMUSG0000006117547


Protein motifs (from Interpro)
Interpro ID Name
 IPR026156  Folliculin-interacting protein family
 IPR028084  Folliculin-interacting protein, N-terminal domain
 IPR028085  Folliculin-interacting protein, middle domain
 IPR028086  Folliculin-interacting protein, C-terminal domain
 IPR037545  Tripartite DENN domain, FNIP1/2-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0002327 immature B cell differentiation IMP
 biological_processGO:0002904 positive regulation of B cell apoptotic process IMP
 biological_processGO:0009267 cellular response to starvation IMP
 biological_processGO:0031334 positive regulation of protein complex assembly IEA
 biological_processGO:0031929 TOR signaling IEA
 biological_processGO:0032007 negative regulation of TOR signaling IMP
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
 biological_processGO:2000973 regulation of pro-B cell differentiation IMP
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042030 ATPase inhibitor activity IEA
 molecular_functionGO:0051087 chaperone binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000172 abnormal bone marrow cell number "Increased or decreased number of cells that make up the core cavities of bones when compared to the norm" [MGI:tc]
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Allelic Composition: Atg3tm1.1Ywh/Atg3tm1.1Ywh,Fnip1m1Btlr/Fnip1m1Btlr,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Fnip1m1Btlr/Fnip1m1Btlr
Genetic Background: C57BL/6J-Fnip1m1Btlr

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Crim1Gt(KST264)Byg/Crim1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

Allelic Composition: Fnip1tm1.2Baba/Fnip1tm1.2Baba
Genetic Background: involves: C57BL/6 * C57BL/6J * FVB/N * SJL

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

Allelic Composition: Fnip1m1Btlr/Fnip1m1Btlr
Genetic Background: C57BL/6J-Fnip1m1Btlr

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Fnip1m1Btlr/Fnip1m1Btlr
Genetic Background: C57BL/6J-Fnip1m1Btlr

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fnip1m1Btlr/Fnip1m1Btlr
Genetic Background: C57BL/6J-Fnip1m1Btlr

Allelic Composition: Fnip1tm1.1Baba/Fnip1tm1.1Baba,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6 * FVB

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

Allelic Composition: Fnip1Gt(RRM154)Byg/Fnip1Gt(RRM154)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Fnip1tm1.2Baba/Fnip1tm1.2Baba
Genetic Background: involves: C57BL/6 * C57BL/6J * FVB/N * SJL

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

Allelic Composition: Fnip1m1Btlr/Fnip1m1Btlr
Genetic Background: C57BL/6J-Fnip1m1Btlr

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Flcntm1Baba/Flcntm1Baba,Fnip1tm1.1Baba/Fnip1tm1.1Baba,Fnip2tm1.1Lss/Fnip2tm1.1Lss,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: C57BL/6 * ICR

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sema3ftm1.2Ddg/Sema3ftm1.2Ddg,Sema3gtm1(KOMP)Vlcg/Sema3gtm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

 MP:0002108 abnormal muscle morphology "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sema3ftm1.2Ddg/Sema3ftm1.2Ddg,Sema3gtm1(KOMP)Vlcg/Sema3gtm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

 MP:0003068 enlarged kidney "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
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Allelic Composition: Fnip1tm1.1Baba/Fnip1tm1.1Baba,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6 * FVB

Allelic Composition: Flcntm1Baba/Flcntm1Baba,Fnip1tm1.1Baba/Fnip1tm1.1Baba,Fnip2tm1.1Lss/Fnip2tm1.1Lss,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: C57BL/6 * ICR

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sema3ftm1.2Ddg/Sema3ftm1.2Ddg,Sema3gtm1(KOMP)Vlcg/Sema3gtm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

 MP:0004978 decreased B-1 B cell number "reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

Allelic Composition: Fnip1Gt(RRM154)Byg/Fnip1Gt(RRM154)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Fnip1tm1.2Baba/Fnip1tm1.2Baba
Genetic Background: involves: C57BL/6 * C57BL/6J * FVB/N * SJL

Allelic Composition: Fnip1tm1.2Baba/Fnip1tm1.2Baba,Tg(IghelMD4)4Ccg/0
Genetic Background: involves: C57BL/6 * C57BL/6J * FVB/N * SJL

Allelic Composition: Fnip1Gt(RRM154)Byg/Fnip1Gt(RRM154)Byg,Tg(IghelMD4)4Ccg/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

Allelic Composition: Fnip1tm1.2Baba/Fnip1tm1.2Baba,Ightm2Cgn/Ightm2Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

Allelic Composition: Fnip1Gt(RRM154)Byg/Fnip1Gt(RRM154)Byg,Ightm2Cgn/Ightm2Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Flcntm1Baba/Flcntm1.1Lss,Tg(CAG-cre/Esr1*)1Lbe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Fnip1tm1.2Baba/Fnip1tm1.2Baba,Tg(BCL2)22Wehi/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fnip1Gt(RRM154)Byg/Fnip1Gt(RRM154)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Fnip1tm1.2Baba/Fnip1tm1.2Baba
Genetic Background: involves: C57BL/6 * C57BL/6J * FVB/N * SJL

 MP:0005330 cardiomyopathy "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]
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Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

 MP:0006036 abnormal mitochondrial physiology 
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Allelic Composition: Fnip1tm1.1Baba/Fnip1tm1.1Baba,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6 * FVB

Allelic Composition: Fnip1tm1.1Baba/Fnip1tm1.1Baba,Fnip2tm1.1Lss/Fnip2tm1.1Lss,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: C57BL/6 * ICR

 MP:0008071 absent B cells "absence of lymphocytes that expresses membrane-bound antibody, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

Allelic Composition: Fnip1Gt(RRM154)Byg/Fnip1Gt(RRM154)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Fnip1tm1.2Baba/Fnip1tm1.2Baba
Genetic Background: involves: C57BL/6 * C57BL/6J * FVB/N * SJL

Allelic Composition: Fnip1tm1.2Baba/Fnip1tm1.2Baba,Tg(IghelMD4)4Ccg/0
Genetic Background: involves: C57BL/6 * C57BL/6J * FVB/N * SJL

Allelic Composition: Fnip1Gt(RRM154)Byg/Fnip1Gt(RRM154)Byg,Tg(IghelMD4)4Ccg/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

Allelic Composition: Fnip1tm1.2Baba/Fnip1tm1.2Baba,Ightm2Cgn/Ightm2Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

Allelic Composition: Fnip1Gt(RRM154)Byg/Fnip1Gt(RRM154)Byg,Ightm2Cgn/Ightm2Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

Allelic Composition: Atg3tm1.1Ywh/Atg3tm1.1Ywh,Fnip1m1Btlr/Fnip1m1Btlr,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Fnip1m1Btlr/Fnip1m1Btlr
Genetic Background: C57BL/6J-Fnip1m1Btlr

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Fnip1m1Btlr/Fnip1m1Btlr
Genetic Background: C57BL/6J-Fnip1m1Btlr

 MP:0008186 increased pro-B cell number "greater number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fnip1Gt(RRM154)Byg/Fnip1Gt(RRM154)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Fnip1tm1.2Baba/Fnip1tm1.2Baba
Genetic Background: involves: C57BL/6 * C57BL/6J * FVB/N * SJL

 MP:0008190 decreased transitional stage B cell number "reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fnip1Gt(RRM154)Byg/Fnip1Gt(RRM154)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Fnip1tm1.2Baba/Fnip1tm1.2Baba
Genetic Background: involves: C57BL/6 * C57BL/6J * FVB/N * SJL

 MP:0008205 absent B-2 cells "absence of conventional B cells subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells" [CL:0000822, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]
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Allelic Composition: Fnip1Gt(RRM154)Byg/Fnip1Gt(RRM154)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Fnip1tm1.2Baba/Fnip1tm1.2Baba
Genetic Background: involves: C57BL/6 * C57BL/6J * FVB/N * SJL

Allelic Composition: Fnip1tm1.2Baba/Fnip1tm1.2Baba,Tg(IghelMD4)4Ccg/0
Genetic Background: involves: C57BL/6 * C57BL/6J * FVB/N * SJL

Allelic Composition: Fnip1Gt(RRM154)Byg/Fnip1Gt(RRM154)Byg,Tg(IghelMD4)4Ccg/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

Allelic Composition: Fnip1tm1.2Baba/Fnip1tm1.2Baba,Ightm2Cgn/Ightm2Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

Allelic Composition: Fnip1Gt(RRM154)Byg/Fnip1Gt(RRM154)Byg,Ightm2Cgn/Ightm2Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fnip1Gt(RRM154)Byg/Fnip1Gt(RRM154)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Fnip1tm1.2Baba/Fnip1tm1.2Baba
Genetic Background: involves: C57BL/6 * C57BL/6J * FVB/N * SJL

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Fnip1Gt(RRM154)Byg/Fnip1Gt(RRM154)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Fnip1tm1.2Baba/Fnip1tm1.2Baba
Genetic Background: involves: C57BL/6 * C57BL/6J * FVB/N * SJL

 MP:0008214 increased immature B cell number "greater number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fnip1tm1.2Baba/Fnip1tm1.2Baba,Tg(IghelMD4)4Ccg/0
Genetic Background: involves: C57BL/6 * C57BL/6J * FVB/N * SJL

Allelic Composition: Fnip1Gt(RRM154)Byg/Fnip1Gt(RRM154)Byg,Tg(IghelMD4)4Ccg/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
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Allelic Composition: Atg3tm1.1Ywh/Atg3tm1.1Ywh,Fnip1m1Btlr/Fnip1m1Btlr,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Fnip1m1Btlr/Fnip1m1Btlr
Genetic Background: C57BL/6J-Fnip1m1Btlr

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

 MP:0008528 polycystic kidney "the development of innumerable cysts in the kidneys filled with fluid replacing much of the mass of the kidneys leading to reduction in kidney function and frequently kidney failure" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Fnip1tm1.1Baba/Fnip1tm1.1Baba,Fnip2tm1.1Lss/Fnip2tm1.1Lss,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: C57BL/6 * ICR

Allelic Composition: Flcntm1Baba/Flcntm1Baba,Fnip1tm1.1Baba/Fnip1tm1.1Baba,Fnip2tm1.1Lss/Fnip2tm1.1Lss,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: C57BL/6 * ICR

 MP:0008782 increased B cell apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

Allelic Composition: Fnip1LPAB.1/Fnip1LPAB.1,Tg(IghMyc)22Bri/0
Genetic Background: involves: C57BL * C57BL/6J * SJL

Allelic Composition: Fnip1Gt(RRM154)Byg/Fnip1Gt(RRM154)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Fnip1tm1.2Baba/Fnip1tm1.2Baba
Genetic Background: involves: C57BL/6 * C57BL/6J * FVB/N * SJL

 MP:0009332 abnormal splenocyte morphology "any structural anomaly of a cell of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fnip1m1Btlr/Fnip1m1Btlr
Genetic Background: C57BL/6J-Fnip1m1Btlr

 MP:0010294 increased kidney tumor incidence "greater than the expected number of tumors originating in the kidney in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Flcntm1Baba/Flcntm1Baba,Fnip1tm1.1Baba/Fnip1tm1.1Baba,Fnip2tm1.1Lss/Fnip2tm1.1Lss,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: C57BL/6 * ICR

 MP:0010392 prolonged QRS complex duration "increase in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fnip1m1Btlr/Fnip1m1Btlr
Genetic Background: C57BL/6J-Fnip1m1Btlr

 MP:0010400 increased liver glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

 MP:0010511 shortened PR interval "decrease in the length of time between the beginning of atrial depolarization and the beginning of ventricular depolarization, measured by the interval from the beginning of the P wave to the beginning of the QRS complex" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fnip1m1Btlr/Fnip1m1Btlr
Genetic Background: C57BL/6J-Fnip1m1Btlr

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Fnip1tm1.1Baba/Fnip1tm1.1Baba,Fnip2tm1.1Lss/Fnip2tm1.1Lss,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: C57BL/6 * ICR

 MP:0014071 increased cardiac muscle glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in heart muscle" [MGI:Anna]
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Allelic Composition: Fnip1m1Btlr/Fnip1m1Btlr
Genetic Background: C57BL/6J-Fnip1m1Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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