ENSMUSG00000036109


Mus musculus

Features
Gene ID: ENSMUSG00000036109
  
Biological name :Mbnl3
  
Synonyms : Mbnl3 / muscleblind like splicing factor 3 / Q8R003
  
Possible biological names infered from orthology : muscleblind like splicing regulator 3 / Q9NUK0
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: A5
Gene start: 51117269
Gene end: 51206532
  
Corresponding Affymetrix probe sets: 10604528 (MoGene1.0st)   1422836_at (Mouse Genome 430 2.0 Array)   1434678_at (Mouse Genome 430 2.0 Array)   1442549_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000046036
Ensembl peptide - ENSMUSP00000110525
Ensembl peptide - ENSMUSP00000110526
Ensembl peptide - ENSMUSP00000138520
NCBI entrez gene - 171170     See in Manteia.
MGI - MGI:2444912
RefSeq - XM_011250981
RefSeq - NM_001310515
RefSeq - NM_134163
RefSeq - XM_006541438
RefSeq - XM_006541439
RefSeq - XM_006541440
RefSeq - XM_006541441
RefSeq - XM_006541442
RefSeq - XM_011250980
RefSeq - XM_006541435
RefSeq - XM_006541436
RefSeq - XM_006541437
RefSeq Peptide - NP_598924
RefSeq Peptide - NP_001297444
swissprot - Q3TJQ3
swissprot - Q542D8
swissprot - Q8R003
swissprot - S4R267
Ensembl - ENSMUSG00000036109
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mbnl3ENSDARG00000016085Danio rerio
 MBNL3ENSGALG00000032045Gallus gallus
 MBNL3ENSG00000076770Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mbnl2 / Q8C181 / Muscleblind-like protein 2 / Q5VZF2* / muscleblind like splicing regulator 2*ENSMUSG0000002213964
Mbnl1 / Q9JKP5 / Muscleblind-like protein 1 / Q9NR56* / muscleblind like splicing regulator 1*ENSMUSG0000002776358


Protein motifs (from Interpro)
Interpro ID Name
 IPR000571  Zinc finger, CCCH-type
 IPR036855  Zinc finger, CCCH-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0043484 regulation of RNA splicing IEA
 biological_processGO:0045662 negative regulation of myoblast differentiation IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000750 abnormal muscle regeneration "inability or defects in ability to repair muscle after injuries" [J:42574]
Show

Allelic Composition: Il7tm1.1Mysl/Il7+
Genetic Background: B6.129P2(Cg)-Il7tm1.1Mysl

Allelic Composition: Mbnl3tm1.1Sws/Y
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J

 MP:0009400 decreased skeletal muscle fiber size "decrease in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il7tm1.1Mysl/Il7+
Genetic Background: B6.129P2(Cg)-Il7tm1.1Mysl

Allelic Composition: Mbnl3tm1.1Sws/Y
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J

 MP:0009406 decreased skeletal muscle fiber number "decreased number of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il7tm1.1Mysl/Il7+
Genetic Background: B6.129P2(Cg)-Il7tm1.1Mysl

Allelic Composition: Mbnl3tm1.1Sws/Y
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Il7tm1.1Mysl/Il7+
Genetic Background: B6.129P2(Cg)-Il7tm1.1Mysl

Allelic Composition: Mbnl3tm1.1Sws/Y
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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