ENSMUSG00000036372


Mus musculus

Features
Gene ID: ENSMUSG00000036372
  
Biological name :Tmem258
  
Synonyms : P61166 / Tmem258 / transmembrane protein 258
  
Possible biological names infered from orthology : P61165
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: A
Gene start: 10204014
Gene end: 10207824
  
Corresponding Affymetrix probe sets: 1425242_at (Mouse Genome 430 2.0 Array)   1428632_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000044751
Ensembl peptide - ENSMUSP00000128883
NCBI entrez gene - 69038     See in Manteia.
MGI - MGI:1916288
RefSeq - NM_001163431
RefSeq - NM_026919
RefSeq Peptide - NP_001156903
RefSeq Peptide - NP_081195
swissprot - Q60FD1
swissprot - P61166
swissprot - E9Q853
Ensembl - ENSMUSG00000036372
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q6PBS6ENSDARG00000078785Danio rerio
 Q76LT9ENSGALG00000038292Gallus gallus
 P61165ENSG00000134825Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007915  Oligosaccharyltransferase complex subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0006487 protein N-linked glycosylation IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0034998 oligosaccharyltransferase I complex IEA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004842 abnormal large intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the large intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Trp53tm1Brn/Trp53tm1Brn,Tg(TPO-cre)1Shk/0
Genetic Background: 129.Cg-Trp53tm1Brn Ptentm2.1Ppp Tg(TPO-cre)1Shk

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Trp53tm1Brn/Trp53tm1Brn,Tg(TPO-cre)1Shk/0
Genetic Background: 129.Cg-Trp53tm1Brn Ptentm2.1Ppp Tg(TPO-cre)1Shk

 MP:0008883 abnormal enterocyte proliferation "anomaly in the ability of the enterocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Trp53tm1Brn/Trp53tm1Brn,Tg(TPO-cre)1Shk/0
Genetic Background: 129.Cg-Trp53tm1Brn Ptentm2.1Ppp Tg(TPO-cre)1Shk

 MP:0008885 increased enterocyte apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Trp53tm1Brn/Trp53tm1Brn,Tg(TPO-cre)1Shk/0
Genetic Background: 129.Cg-Trp53tm1Brn Ptentm2.1Ppp Tg(TPO-cre)1Shk

 MP:0010180 increased susceptibility to weight loss "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Trp53tm1Brn/Trp53tm1Brn,Tg(TPO-cre)1Shk/0
Genetic Background: 129.Cg-Trp53tm1Brn Ptentm2.1Ppp Tg(TPO-cre)1Shk

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Trp53tm1Brn/Trp53tm1Brn,Tg(TPO-cre)1Shk/0
Genetic Background: 129.Cg-Trp53tm1Brn Ptentm2.1Ppp Tg(TPO-cre)1Shk

 MP:0012556 increased cell death "increased occurrence of the cessation of function at the cellular level" [http://orcid.org/0000-0001-5208-3432]
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Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Trp53tm1Brn/Trp53tm1Brn,Tg(TPO-cre)1Shk/0
Genetic Background: 129.Cg-Trp53tm1Brn Ptentm2.1Ppp Tg(TPO-cre)1Shk

 MP:0013298 increased susceptibility to colitis induced morbidity/mortality " increased likelihood that an organism will display the expected moribund state caused by colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:Annie_Speak]
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Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Trp53tm1Brn/Trp53tm1Brn,Tg(TPO-cre)1Shk/0
Genetic Background: 129.Cg-Trp53tm1Brn Ptentm2.1Ppp Tg(TPO-cre)1Shk

 MP:0013956 decreased colon length "reduced length of the portion of the large intestine between the cecum and the rectum" [ISBN:0683400088]
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Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Trp53tm1Brn/Trp53tm1Brn,Tg(TPO-cre)1Shk/0
Genetic Background: 129.Cg-Trp53tm1Brn Ptentm2.1Ppp Tg(TPO-cre)1Shk

 MP:0020354 increased endoplasmic reticulum stress "increase in in the accumulation of misfolded or unfolded proteins in the endoplasmic reticulum lumen; this accumulation may be stimulated by genetic or enviromental factors" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Trp53tm1Brn/Trp53tm1Brn,Tg(TPO-cre)1Shk/0
Genetic Background: 129.Cg-Trp53tm1Brn Ptentm2.1Ppp Tg(TPO-cre)1Shk

Allelic Composition: Gt(ROSA)26Sortm1(CAG-cas9*,-EGFP)Fezh/?,Tmem258tm1.1(KOMP)Vlcg/Tmem258+
Genetic Background: involves: C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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