ENSMUSG00000036555


Mus musculus

Features
Gene ID: ENSMUSG00000036555
  
Biological name :Iqce
  
Synonyms : Iqce / IQ domain-containing protein E / Q6PCQ0
  
Possible biological names infered from orthology : IQ motif containing E / Q6IPM2
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G2
Gene start: 140661827
Gene end: 140702378
  
Corresponding Affymetrix probe sets: 10535247 (MoGene1.0st)   1431246_at (Mouse Genome 430 2.0 Array)   1434622_at (Mouse Genome 430 2.0 Array)   1457897_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000045913
Ensembl peptide - ENSMUSP00000120637
Ensembl peptide - ENSMUSP00000121457
Ensembl peptide - ENSMUSP00000143397
Ensembl peptide - ENSMUSP00000077050
NCBI entrez gene - 74239     See in Manteia.
MGI - MGI:1921489
RefSeq - XM_011240985
RefSeq - XM_006504743
RefSeq - XM_006504744
RefSeq - XM_006504745
RefSeq - XM_006504746
RefSeq - XM_006504747
RefSeq - XM_006504748
RefSeq - NM_028833
RefSeq - XM_006504739
RefSeq - XM_006504740
RefSeq - XM_006504741
RefSeq - XM_006504742
RefSeq Peptide - NP_001334446
RefSeq Peptide - NP_083109
swissprot - F6R782
swissprot - D3YXD4
swissprot - A0A0G2JG25
swissprot - Q6PCQ0
Ensembl - ENSMUSG00000036555
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 iqceENSDARG00000089930Danio rerio
 IQCEENSGALG00000004329Gallus gallus
 IQCEENSG00000106012Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0019898 extrinsic component of membrane IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0060170 ciliary membrane IEA
 cellular_componentGO:0098797 plasma membrane protein complex IDA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Activation of SMO


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0001257 increased body length "increased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0002966 decreased circulating alkaline phosphatase level "reduced activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0004357 long tibia "increased length of the medial and larger of the two bones of the lower leg" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0010052 increased grip strength "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0011965 decreased total retina thickness "decreased width of the retina through the center plane" [MGI:csmith]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029122 Evc / P57680 / Ellis-van Creveld syndrome protein homolog / P57679* / EvC ciliary complex subunit 1*  / reaction / complex
 ENSMUSG00000050248 Evc2 / Q8K1G2 / Limbin / Q86UK5* / EvC ciliary complex subunit 2*  / complex / reaction






 

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