ENSMUSG00000036587


Mus musculus

Features
Gene ID: ENSMUSG00000036587
  
Biological name :Fut7
  
Synonyms : Alpha-(1,3)-fucosyltransferase 7 / Fut7 / Q11131
  
Possible biological names infered from orthology : fucosyltransferase 7 / Q11130
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: A3
Gene start: 25423267
Gene end: 25426374
  
Corresponding Affymetrix probe sets: 10470042 (MoGene1.0st)   1420756_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123526
Ensembl peptide - ENSMUSP00000039985
Ensembl peptide - ENSMUSP00000097895
Ensembl peptide - ENSMUSP00000109917
NCBI entrez gene - 14347     See in Manteia.
MGI - MGI:107692
RefSeq - XM_006497704
RefSeq - NM_001177366
RefSeq - NM_001177367
RefSeq - NM_001289453
RefSeq - NM_001289454
RefSeq - NM_001289455
RefSeq - NM_001289456
RefSeq - NM_013524
RefSeq Peptide - NP_001276385
RefSeq Peptide - NP_038552
RefSeq Peptide - NP_001170838
RefSeq Peptide - NP_001276382
RefSeq Peptide - NP_001170837
RefSeq Peptide - NP_001276383
RefSeq Peptide - NP_001276384
swissprot - Q3SWS0
swissprot - E2D0W5
swissprot - Q11131
swissprot - A2AJ24
Ensembl - ENSMUSG00000036587
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fut7ENSDARG00000044775Danio rerio
 FUT7ENSGALG00000034975Gallus gallus
 FUT7ENSG00000180549Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fut4 / Q11127 / Alpha-(1,3)-fucosyltransferase 4 / P22083* / fucosyltransferase 4*ENSMUSG0000004930738
Fut9 / O88819 / Alpha-(1,3)-fucosyltransferase 9 / Q9Y231* / fucosyltransferase 9*ENSMUSG0000005537330
Fut10 / Q5F2L2 / Alpha-(1,3)-fucosyltransferase 10 / Q6P4F1* / fucosyltransferase 10*ENSMUSG0000004615223
Fut11 / Q8BHC9 / Alpha-(1,3)-fucosyltransferase 11 / Q495W5* / fucosyltransferase 11*ENSMUSG0000003935721


Protein motifs (from Interpro)
Interpro ID Name
 IPR001503  Glycosyl transferase family 10
 IPR031481  Fucosyltransferase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IMP
 biological_processGO:0002522 leukocyte migration involved in immune response IMP
 biological_processGO:0006486 protein glycosylation ISO
 biological_processGO:0006672 ceramide metabolic process ISO
 biological_processGO:0036065 fucosylation IEA
 cellular_componentGO:0000139 Golgi membrane IBA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032580 Golgi cisterna membrane IEA
 molecular_functionGO:0008417 fucosyltransferase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0046920 alpha-(1->3)-fucosyltransferase activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fut4tm1Jbl/Fut4tm1Jbl,Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: B6.129S2-Fut7tm1Jbl Fut4tm1Jbl

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fut4tm1Jbl/Fut4tm1Jbl,Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: B6.129S2-Fut7tm1Jbl Fut4tm1Jbl

 MP:0000511 abnormal intestinal mucosa morphology "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gja10tm1Kwi/Gja10+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001273 decreased metastatic potential 
Show

Allelic Composition: Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: B6.129S2-Fut7tm1Jbl

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Olig1tm1(cre)Rth/Olig1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0002217 small lymph nodes "lymph nodes of decreased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fut4tm1Jbl/Fut4tm1Jbl,Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: B6.129S2-Fut7tm1Jbl Fut4tm1Jbl

 MP:0002345 abnormal lymph node primary follicle "anomaly in the immunologically inactive B cell area of the lymph node cortex" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Olig1tm1(cre)Rth/Olig1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Fut4tm1Jbl/Fut4tm1Jbl,Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: B6.129S2-Fut7tm1Jbl Fut4tm1Jbl

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fut4tm1Jbl/Fut4tm1Jbl,Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: B6.129S2-Fut7tm1Jbl Fut4tm1Jbl

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Olig1tm1(cre)Rth/Olig1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Fut4tm1Jbl/Fut4tm1Jbl,Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: B6.129S2-Fut7tm1Jbl Fut4tm1Jbl

 MP:0002462 abnormal granulocyte physiology "functional anomaly of neutrophils, eosinophils, or basophils " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Olig1tm1(cre)Rth/Olig1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fut4tm1Jbl/Fut4tm1Jbl,Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: B6.129S2-Fut7tm1Jbl Fut4tm1Jbl

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Fut4tm1Jbl/Fut4tm1Jbl,Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: B6.129S2-Fut7tm1Jbl Fut4tm1Jbl

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Olig1tm1(cre)Rth/Olig1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Fut4tm1Jbl/Fut4tm1Jbl,Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: B6.129S2-Fut7tm1Jbl Fut4tm1Jbl

 MP:0003627 abnormal lymphocyte rolling "anomaly in the number or velocity of lymphocytes rolling along the luminal aspects of high endothelial venules" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95656]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Olig1tm1(cre)Rth/Olig1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0003628 abnormal lymphocyte adhesion "anomaly in the number of or process by which lymphocytes adhere to the luminal aspects of high endothelial venules prior to transmigration out of the vessel" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95656]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Olig1tm1(cre)Rth/Olig1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0005338 atherosclerotic lesions "thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Fut4tm1Jbl/Fut4tm1Jbl,Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fut4tm1Jbl/Fut4tm1Jbl,Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: B6.129S2-Fut7tm1Jbl Fut4tm1Jbl

Allelic Composition: Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: B6.129S2-Fut7tm1Jbl

 MP:0008101 lymph node hypoplasia "underdevelopment or reduced size, usually due to a reduced cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fut4tm1Jbl/Fut4tm1Jbl,Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: B6.129S2-Fut7tm1Jbl Fut4tm1Jbl

 MP:0008255 decreased megakaryocyte cell number "reduced number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Olig1tm1(cre)Rth/Olig1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Olig1tm1(cre)Rth/Olig1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: B6.129S2-Fut7tm1Jbl

 MP:0010792 abnormal stomach mucosa morphology "any structural anomaly of the mucous layer of the stomach wall which contains the gastric pits and glands, and consists of epithelium, lamina propria, and the muscularis mucosae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gja10tm1Kwi/Gja10+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0020332 impaired leukocyte tethering or rolling "reduced ability or inability in the transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation" [GO:0050901, ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Fut4tm1Jbl/Fut4tm1Jbl,Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: B6.129S2-Fut7tm1Jbl Fut4tm1Jbl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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