ENSMUSG00000036620


Mus musculus

Features
Gene ID: ENSMUSG00000036620
  
Biological name :Mgat4b
  
Synonyms : Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B / Mgat4b / Q812F8
  
Possible biological names infered from orthology : mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B / Q9UQ53
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B1.3
Gene start: 50210890
Gene end: 50235103
  
Corresponding Affymetrix probe sets: 10375713 (MoGene1.0st)   1424720_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116802
Ensembl peptide - ENSMUSP00000119786
Ensembl peptide - ENSMUSP00000043346
NCBI entrez gene - 103534     See in Manteia.
MGI - MGI:2143974
RefSeq - NM_145926
RefSeq Peptide - NP_666038
swissprot - Q812F8
swissprot - A8Y5H5
swissprot - F7BME0
Ensembl - ENSMUSG00000036620
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mgat4bENSDARG00000004115Danio rerio
 MGAT4BENSGALG00000005924Gallus gallus
 MGAT4BENSG00000161013Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mgat4a / Q812G0 / Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A soluble form / Q9UM21* / ...ENSMUSG0000002611060
Mgat4d / Q9D4R2 / Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D / A6NG13* / MGAT4 family member D*ENSMUSG0000003505725
Mgat4c / Q9D306 / Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C / Q9UBM8* / MGAT4 family member C*ENSMUSG0000001988825
4933406M09Rik / RIKEN cDNA 4933406M09 geneENSMUSG0000005052618
A6H684 / Mgat4e / Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4E ENSMUSG0000004636717


Protein motifs (from Interpro)
Interpro ID Name
 IPR006759  Glycosyl transferase family 54


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0006487 protein N-linked glycosylation IGI
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0008375 acetylglucosaminyltransferase activity IDA
 molecular_functionGO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IDA
 molecular_functionGO:0016758 transferase activity, transferring hexosyl groups IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
N-Glycan antennae elongation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Grid2ho-19J/Grid2ho-19J
Genetic Background: C57BL/6J-Grid2ho-19J/GrsrJ

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Grid2ho-19J/Grid2ho-19J
Genetic Background: C57BL/6J-Grid2ho-19J/GrsrJ

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Grid2ho-19J/Grid2ho-19J
Genetic Background: C57BL/6J-Grid2ho-19J/GrsrJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Zbtb7bhpls/Zbtb7bhpls
Genetic Background: involves: C57BL/6JAnu

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Grid2ho-19J/Grid2ho-19J
Genetic Background: C57BL/6J-Grid2ho-19J/GrsrJ

 MP:0005146 decreased circulating VLDL cholesterol level "less than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Grid2ho-19J/Grid2ho-19J
Genetic Background: C57BL/6J-Grid2ho-19J/GrsrJ

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Grid2ho-19J/Grid2ho-19J
Genetic Background: C57BL/6J-Grid2ho-19J/GrsrJ

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Grid2ho-19J/Grid2ho-19J
Genetic Background: C57BL/6J-Grid2ho-19J/GrsrJ

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Grid2ho-19J/Grid2ho-19J
Genetic Background: C57BL/6J-Grid2ho-19J/GrsrJ

 MP:0010068 decreased red blood cell distribution width "lower than normal coefficient of variance (reference range) of the red blood cell volume for an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", NCI:C64800 "NCI Thesaurus (Code C64800)"]
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Allelic Composition: Grid2ho-19J/Grid2ho-19J
Genetic Background: C57BL/6J-Grid2ho-19J/GrsrJ

 MP:0012222 decreased prothrombin level "reduction in the level of an inactive plasma serine protease precursor produced in the liver in the presence of vitamin K which is proteolytically cleaved into active thrombin by the action of various components (as thromboplastin) of the coagulation cascade" [MGI:csmith]
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Allelic Composition: Grid2ho-19J/Grid2ho-19J
Genetic Background: C57BL/6J-Grid2ho-19J/GrsrJ

 MP:0012328 decreased circulating factor VIII level "reduced levels of the antihemophilic factor that is part of the factor VIII/von Willebrand factor complex; it is produced in the liver and acts in the intrinsic pathway of blood coagulation; it serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin" [MeSH:D12.776.124.125.350, MPD:Molly]
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Allelic Composition: Grid2ho-19J/Grid2ho-19J
Genetic Background: C57BL/6J-Grid2ho-19J/GrsrJ

 MP:0012359 increased partial thromboplastin time "increased amount of time it takes blood to clot after the addition of phospholipid, calcium, and an activator, e.g., silica, kaolin; measure of the quality of the intrinsic and common coagulation pathways" [MPD:Molly]
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Allelic Composition: Grid2ho-19J/Grid2ho-19J
Genetic Background: C57BL/6J-Grid2ho-19J/GrsrJ

 MP:0012615 decreased circulating factor IX level 
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Allelic Composition: Grid2ho-19J/Grid2ho-19J
Genetic Background: C57BL/6J-Grid2ho-19J/GrsrJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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