ENSMUSG00000036858


Mus musculus

Features
Gene ID: ENSMUSG00000036858
  
Biological name :Ptcra
  
Synonyms : pre T cell antigen receptor alpha / Ptcra
  
Possible biological names infered from orthology : Q6ISU1
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: C
Gene start: 46755663
Gene end: 46763712
  
Corresponding Affymetrix probe sets: 10451465 (MoGene1.0st)   1421760_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000035683
NCBI entrez gene - 19208     See in Manteia.
MGI - MGI:104857
RefSeq - NM_011195
RefSeq Peptide - NP_035325
swissprot - A0A0R4J0F4
Ensembl - ENSMUSG00000036858
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000045228Gallus gallus
 PTCRAENSG00000171611Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR013783  Immunoglobulin-like fold
 IPR027834  Pre-T-cell antigen receptor
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
No match


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
Show

Allelic Composition: Nat1Rgsc1523/Nat1+
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Nat1Rgsc1523/Nat1+
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: H2b/H2b,Ptcratm1Vbo/Ptcratm1Vbo,Tcratm1Mom/Tcra/Tcrdtm1.1(Tcra)Rsky,Tg(Tcrb)93Vbo/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

Allelic Composition: Tcratm1Mom/Tcra/Tcrdtm1.1(Tcra)Rsky,H2d/H2d,Ptcratm1Vbo/Ptcratm1Vbo,Tg(Tcrb)93Vbo/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

Allelic Composition: Ptcratm1.1Shoy/Ptcratm1.1Shoy
Genetic Background: involves: C57BL/6

Allelic Composition: Ptcratm1(icre)Hjf/Ptcratm1(icre)Hjf
Genetic Background: B6.129P2-Ptcratm1(icre)Hjf

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: a/a,Hps6ru/Hps6ru
Genetic Background: B6.Cg-Hps6ru

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Asy/a
Genetic Background: C57BL/6J-Asy/a/J

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: a/a,Hps6ru/Hps6ru
Genetic Background: B6.Cg-Hps6ru

Allelic Composition: H2b/H2b,Ptcratm1Vbo/Ptcratm1Vbo,Tcratm1Mom/Tcra/Tcrdtm1.1(Tcra)Rsky,Tg(Tcrb)93Vbo/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

Allelic Composition: Tcratm1Mom/Tcra/Tcrdtm1.1(Tcra)Rsky,H2d/H2d,Ptcratm1Vbo/Ptcratm1Vbo,Tg(Tcrb)93Vbo/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

Allelic Composition: H2b/H2b,Ptcratm1Vbo/Ptcratm1Vbo,Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0002408 abnormal double-positive T cell "anomalous development or number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: a/a,Hps6ru/Hps6ru
Genetic Background: B6.Cg-Hps6ru

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptcratm1.1Shoy/Ptcratm1.1Shoy
Genetic Background: involves: C57BL/6

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptcratm1.1Shoy/Ptcratm1.1Shoy
Genetic Background: involves: C57BL/6

 MP:0005089 decreased double-negative T cell count "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: a/a,Hps6ru/Hps6ru
Genetic Background: B6.Cg-Hps6ru

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Asy/a
Genetic Background: C57BL/6J-Asy/a/J

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Nat1Rgsc1523/Nat1+
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Ptcratm1.1Shoy/Ptcratm1.1Shoy
Genetic Background: involves: C57BL/6

Allelic Composition: Ptcratm1(icre)Hjf/Ptcratm1(icre)Hjf
Genetic Background: B6.129P2-Ptcratm1(icre)Hjf

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: a/a,Hps6ru/Hps6ru
Genetic Background: B6.Cg-Hps6ru

 MP:0008346 increased gamma-delta T cell number "greater number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
Show

Allelic Composition: Ptcratm1.1Shoy/Ptcratm1.1Shoy
Genetic Background: involves: C57BL/6

 MP:0010133 increased DN3 thymocyte number "increased number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain." [CL:0000807]
Show

Allelic Composition: a/a,Hps6ru/Hps6ru
Genetic Background: B6.Cg-Hps6ru

Allelic Composition: Ptcratm1.1Shoy/Ptcratm1.1Shoy
Genetic Background: involves: C57BL/6

 MP:0010136 decreased DN4 thymocyte number "reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive." [CL:0000808]
Show

Allelic Composition: a/a,Hps6ru/Hps6ru
Genetic Background: B6.Cg-Hps6ru

Allelic Composition: Ptcratm1(icre)Hjf/Ptcratm1(icre)Hjf
Genetic Background: B6.129P2-Ptcratm1(icre)Hjf

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr