ENSMUSG00000037058


Mus musculus

Features
Gene ID: ENSMUSG00000037058
  
Biological name :Paip2
  
Synonyms : Paip2 / Polyadenylate-binding protein-interacting protein 2 / Q9D6V8
  
Possible biological names infered from orthology : poly(A) binding protein interacting protein 2 / Q9BPZ3
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: B2
Gene start: 35598617
Gene end: 35617186
  
Corresponding Affymetrix probe sets: 10454831 (MoGene1.0st)   1448493_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000111400
Ensembl peptide - ENSMUSP00000111401
Ensembl peptide - ENSMUSP00000111402
Ensembl peptide - ENSMUSP00000111399
Ensembl peptide - ENSMUSP00000036021
NCBI entrez gene - 67869     See in Manteia.
MGI - MGI:1915119
RefSeq - XM_017317973
RefSeq - NM_026420
RefSeq - XM_011246987
RefSeq - XM_011246988
RefSeq - XM_011246989
RefSeq - XM_011246990
RefSeq - XM_017317972
RefSeq Peptide - NP_001344399
RefSeq Peptide - NP_001344400
RefSeq Peptide - NP_001344401
RefSeq Peptide - NP_001344402
RefSeq Peptide - NP_080696
swissprot - Q9D6V8
Ensembl - ENSMUSG00000037058
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PAIP2ENSGALG00000002488Gallus gallus
 PAIP2ENSG00000120727Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Paip2b / Q91W45 / Polyadenylate-binding protein-interacting protein 2B / Q9ULR5* / poly(A) binding protein interacting protein 2B*ENSMUSG0000004589651


Protein motifs (from Interpro)
Interpro ID Name
 IPR009818  Ataxin-2, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006417 regulation of translation IMP
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0007613 memory IMP
 biological_processGO:0017148 negative regulation of translation ISO
 biological_processGO:0045947 negative regulation of translational initiation IEA
 biological_processGO:1900271 regulation of long-term synaptic potentiation IMP
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000900 translation repressor activity, mRNA regulatory element binding ISO
 molecular_functionGO:0003729 mRNA binding IDA
 molecular_functionGO:0008143 poly(A) binding ISO
 molecular_functionGO:0030371 translation repressor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Fevtm1Esd/Fevtm2Esd,Tg(Fev-cre/ERT2)aEsd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Fevtm1Esd/Fevtm2Esd,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Tg(Fev-cre)1Esd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Paip2tm1.2Nso/Paip2tm1.2Nso,Paip2btm1.2Nso/Paip2btm1.2Nso
Genetic Background: B6.129-Paip2btm1.2Nso Paip2tm1.2Nso

 MP:0001932 abnormal spermiogenesis "failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fevtm1Esd/Fevtm2Esd,Tg(Fev-cre/ERT2)aEsd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002662 abnormal cauda "anomalous structure of the tail of the epididymis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fevtm1Esd/Fevtm2Esd,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Tg(Fev-cre)1Esd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Paip2tm1.2Nso/Paip2tm1.2Nso,Paip2btm1.2Nso/Paip2btm1.2Nso
Genetic Background: B6.129-Paip2btm1.2Nso Paip2tm1.2Nso

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Paip2tm1.2Nso/Paip2tm1.2Nso,Paip2btm1.2Nso/Paip2btm1.2Nso
Genetic Background: B6.129-Paip2btm1.2Nso Paip2tm1.2Nso

 MP:0004929 decreased epididymis weight "reduction in the average weight of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Paip2tm1.2Nso/Paip2tm1.2Nso,Paip2btm1.2Nso/Paip2btm1.2Nso
Genetic Background: B6.129-Paip2btm1.2Nso Paip2tm1.2Nso

 MP:0004962 decreased prostate weight "reduction in the average weight of the gland in males that secretes part of the seminiferous fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Paip2tm1.2Nso/Paip2tm1.2Nso,Paip2btm1.2Nso/Paip2btm1.2Nso
Genetic Background: B6.129-Paip2btm1.2Nso Paip2tm1.2Nso

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Paip2tm1.2Nso/Paip2tm1.2Nso,Paip2btm1.2Nso/Paip2btm1.2Nso
Genetic Background: B6.129-Paip2btm1.2Nso Paip2tm1.2Nso

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Paip2tm1.2Nso/Paip2tm1.2Nso,Paip2btm1.2Nso/Paip2btm1.2Nso
Genetic Background: B6.129-Paip2btm1.2Nso Paip2tm1.2Nso

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Paip2tm1.2Nso/Paip2tm1.2Nso,Paip2btm1.2Nso/Paip2btm1.2Nso
Genetic Background: B6.129-Paip2btm1.2Nso Paip2tm1.2Nso

 MP:0009231 detached acrosome "detachment or loss of adhesion of the acrosome cap from the sperm head nucleus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Paip2tm1.2Nso/Paip2tm1.2Nso,Paip2btm1.2Nso/Paip2btm1.2Nso
Genetic Background: B6.129-Paip2btm1.2Nso Paip2tm1.2Nso

 MP:0009232 abnormal sperm nucleus morphology "any structural abnormality of the sperm head nucleus, including an abnormal nuclear shape or defects in the compaction of nuclear chromatin" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Paip2tm1.2Nso/Paip2tm1.2Nso,Paip2btm1.2Nso/Paip2btm1.2Nso
Genetic Background: B6.129-Paip2btm1.2Nso Paip2tm1.2Nso

 MP:0009833 absent sperm mitochondrial sheath "absence of the tightly packed helical sheath of ATP-producing mitochondria, normally found in the midpiece of the sperm flagellum" [PMID:14581499]
Show

Allelic Composition: Paip2tm1.2Nso/Paip2tm1.2Nso,Paip2btm1.2Nso/Paip2btm1.2Nso
Genetic Background: B6.129-Paip2btm1.2Nso Paip2tm1.2Nso

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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