ENSMUSG00000037224


Mus musculus

Features
Gene ID: ENSMUSG00000037224
  
Biological name :Zfyve28
  
Synonyms : Q6ZPK7 / Zfyve28 / zinc finger, FYVE domain containing 28
  
Possible biological names infered from orthology : Q9HCC9 / zinc finger FYVE-type containing 28
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: B2
Gene start: 34194893
Gene end: 34288449
  
Corresponding Affymetrix probe sets: 10529385 (MoGene1.0st)   1434504_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000092464
Ensembl peptide - ENSMUSP00000110008
NCBI entrez gene - 231125     See in Manteia.
MGI - MGI:2684992
RefSeq - XM_011240724
RefSeq - NM_001015039
RefSeq - XM_006503886
RefSeq Peptide - NP_001015039
swissprot - Q6ZPK7
swissprot - D3Z3F0
Ensembl - ENSMUSG00000037224
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zfyve28ENSDARG00000060430Danio rerio
 Q9HCC9ENSG00000159733Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q80U44 / Zfyve16 / zinc finger, FYVE domain containing 16 / Q7Z3T8* / zinc finger FYVE-type containing 16*ENSMUSG0000002170614
Zfyve9 / zinc finger, FYVE domain containing 9 / O95405* / zinc finger FYVE-type containing 9*ENSMUSG0000003455713
Q9Z1T6 / Pikfyve / phosphoinositide kinase, FYVE type zinc finger containing / Q9Y2I7*ENSMUSG000000259499
Q8VCM3 / Zfyve21 / zinc finger, FYVE domain containing 21 / Q9BQ24* / zinc finger FYVE-type containing 21*ENSMUSG000000212863


Protein motifs (from Interpro)
Interpro ID Name
 IPR000306  FYVE zinc finger
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017455  Zinc finger, FYVE-related


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007175 negative regulation of epidermal growth factor-activated receptor activity IEA
 biological_processGO:0042059 negative regulation of epidermal growth factor receptor signaling pathway IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031901 early endosome membrane ISS
 molecular_functionGO:0032266 phosphatidylinositol-3-phosphate binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Zfp719tm1b(EUCOMM)Wtsi/Zfp719tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Zfp719tm1b(EUCOMM)Wtsi/Wtsi

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Zfp719tm1b(EUCOMM)Wtsi/Zfp719tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Zfp719tm1b(EUCOMM)Wtsi/Wtsi

 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Zfp719tm1b(EUCOMM)Wtsi/Zfp719tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Zfp719tm1b(EUCOMM)Wtsi/Wtsi

 MP:0008810 increased circulating iron level "elevation in the concentration of iron in the blood" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Zfp719tm1b(EUCOMM)Wtsi/Zfp719tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Zfp719tm1b(EUCOMM)Wtsi/Wtsi

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zfp719tm1b(EUCOMM)Wtsi/Zfp719tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Zfp719tm1b(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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