ENSMUSG00000037251


Mus musculus

Features
Gene ID: ENSMUSG00000037251
  
Biological name :Pomk
  
Synonyms : Pomk / Protein O-mannose kinase / Q3TUA9
  
Possible biological names infered from orthology : Q9H5K3
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: A2
Gene start: 25980604
Gene end: 25994133
  
Corresponding Affymetrix probe sets: 10577903 (MoGene1.0st)   1424003_at (Mouse Genome 430 2.0 Array)   1424004_x_at (Mouse Genome 430 2.0 Array)   1447867_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000053802
NCBI entrez gene - 74653     See in Manteia.
MGI - MGI:1921903
RefSeq - NM_029037
RefSeq Peptide - NP_083313
swissprot - Q3TUA9
Ensembl - ENSMUSG00000037251
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pomkENSDARG00000003208Danio rerio
 POMKENSGALG00000026210Gallus gallus
 POMKENSG00000185900Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR011009  Protein kinase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006493 protein O-linked glycosylation IEA
 biological_processGO:0007420 brain development IMP
 biological_processGO:0007611 learning or memory IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0019233 sensory perception of pain IMP
 biological_processGO:0046835 carbohydrate phosphorylation IEA
 biological_processGO:0050905 neuromuscular process IMP
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016773 phosphotransferase activity, alcohol group as acceptor IEA
 molecular_functionGO:0019200 carbohydrate kinase activity IDA


Pathways (from Reactome)
Pathway description
O-linked glycosylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Stk36tm1Lex/Stk36tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
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Allelic Composition: Stk36tm1Lex/Stk36tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Stk36tm1Lex/Stk36tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0000857 abnormal cerebellar foliation "malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951]
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Allelic Composition: Stk36tm1Lex/Stk36tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0000885 ectopic Purkinje cell "Purkinje cell body resides in places other than the Purkinje cell layer in the cerebellum" [MGI:tc, J:60896]
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Allelic Composition: Stk36tm1Lex/Stk36tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Stk36tm1Lex/Stk36tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Stk36tm1Lex/Stk36tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002635 reduced sensorimotor gating 
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Allelic Composition: Stk36tm1Lex/Stk36tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002762 ectopic granule cells "granule cell body resides in a place other than the external or internal granule layer of the cerebellum" [J:4978]
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Allelic Composition: Stk36tm1Lex/Stk36tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0004097 abnormal cerebellar cortex morphology "any structural anomaly of the thin mantle of gray matter that covers the surface of each cerebral hemisphere, including the six layers of nerve cells and the nerve pathways that connect them; together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Stk36tm1Lex/Stk36tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Stk36tm1Lex/Stk36tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0008531 increased chemical nociceptive threshold "a greater than average concentration at which chemically induced pain sensation is first detectable" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stk36tm1Lex/Stk36tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Stk36tm1Lex/Stk36tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0009456 impaired cued conditioning behavior "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Stk36tm1Lex/Stk36tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0009956 abnormal cerebellar layer morphology "any structural anomaly of the laminar structure of the cerebellar cortex comprising the gray matter of the cerebellum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stk36tm1Lex/Stk36tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0009977 abnormal cerebellar granule cell migration "defective or impaired movement of cerebellar granule cell neurons from the germinal zone into the granule cell layer of the cerebellum during development of the cerebellar cortex" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stk36tm1Lex/Stk36tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0010008 abnormal Purkinje cell migration "defective or impaired movement of immature Purkinje cells from the ventricular zone of the fourth ventricle to the forming Purkinje cell layer during development of the cerebellar cortex" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stk36tm1Lex/Stk36tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Stk36tm1Lex/Stk36tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011495 abnormal head shape "any anomaly in the characteristic surface outline or contour of a head of an organism" [MGI:csmith]
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Allelic Composition: Stk36tm1Lex/Stk36tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000039952 Dag1 / Q62165 / Dystroglycan Alpha-dystroglycan Beta-dystroglycan / Q14118* / dystroglycan 1*  / reaction






 

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