| MP:0000111 | cleft palate | "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840] |
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Allelic Composition: Ror1tm1.2Meg/Ror1tm1.2Meg,Ror2tm1.2Meg/Ror2tm1.2Meg
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
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| MP:0000914 | exencephaly | "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840] |
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Allelic Composition: Bbs7tm1Vcs/Bbs7tm1Vcs,Ift88Tg737Rpw/Ift88Tg737Rpw
Genetic Background: involves: FVB/N
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| MP:0001260 | increased body weight | "greater than normal average weight " [J:33400] |
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Allelic Composition: Pcdhgtm2Xzw/Pcdhgtm2Xzw,Robo2tm1Rilm/Robo2tm1Rilm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1
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| MP:0001261 | obese | "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: Pcdhgtm2Xzw/Pcdhgtm2Xzw,Robo2tm1Rilm/Robo2tm1Rilm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1
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| MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Pcdhgtm2Xzw/Pcdhgtm2Xzw,Robo2tm1Rilm/Robo2tm1Rilm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1
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| MP:0001293 | anophthalmia | "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979] |
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Allelic Composition: Ror1tm1.2Meg/Ror1tm1.2Meg,Ror2tm1.2Meg/Ror2tm1.2Meg
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
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| MP:0001326 | retinal degeneration | "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator] |
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Allelic Composition: Pcdhgtm2Xzw/Pcdhgtm2Xzw,Robo2tm1Rilm/Robo2tm1Rilm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1
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| MP:0001787 | pericardial edema | "accumulation of watery fluid in the pericardial sac of the heart" [J:52597] |
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Allelic Composition: Ror1tm1.2Meg/Ror1tm1.2Meg,Ror2tm1.2Meg/Ror2tm1.2Meg
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
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| MP:0001925 | male infertility | "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409] |
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Allelic Composition: Pcdhgtm2Xzw/Pcdhgtm2Xzw,Robo2tm1Rilm/Robo2tm1Rilm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1
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| MP:0004574 | broad limb buds | "increased anterior-posterior width of the mesenchymal outgrowth on the lateral trunk of the embryo that develops into the limbs" [MESH:National Library of Medicine_Medical Subject Headings] |
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Allelic Composition: Bbs7tm1Vcs/Bbs7tm1Vcs,Ift88Tg737Rpw/Ift88Tg737Rpw
Genetic Background: involves: FVB/N
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| MP:0006254 | thin cerebral cortex | "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683] |
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Allelic Composition: Pcdhgtm2Xzw/Pcdhgtm2Xzw,Robo2tm1Rilm/Robo2tm1Rilm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1
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| MP:0006279 | abnormal limb development | "anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bbs7tm1Vcs/Bbs7tm1Vcs,Ift88Tg737Rpw/Ift88Tg737Rpw
Genetic Background: involves: FVB/N
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| MP:0008283 | small hippocampus | "reduced size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pcdhgtm2Xzw/Pcdhgtm2Xzw,Robo2tm1Rilm/Robo2tm1Rilm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1
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| MP:0008518 | retinal outer nuclear layer degeneration | "a retrogressive impairment or destruction of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pcdhgtm2Xzw/Pcdhgtm2Xzw,Robo2tm1Rilm/Robo2tm1Rilm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1
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| MP:0008535 | enlarged lateral ventricles | "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pcdhgtm2Xzw/Pcdhgtm2Xzw,Robo2tm1Rilm/Robo2tm1Rilm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1
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| MP:0008536 | enlarged third ventricle | "increased size of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [MESH:A08.186.211.276.840, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pcdhgtm2Xzw/Pcdhgtm2Xzw,Robo2tm1Rilm/Robo2tm1Rilm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1
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| MP:0008545 | absent sperm flagella | "mature spermatozoa lack a flagella" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pcdhgtm2Xzw/Pcdhgtm2Xzw,Robo2tm1Rilm/Robo2tm1Rilm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1
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| MP:0008580 | photoreceptor inner segment degeneration | "retrogressive pathologic change in the photoreceptor region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pcdhgtm2Xzw/Pcdhgtm2Xzw,Robo2tm1Rilm/Robo2tm1Rilm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1
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| MP:0008584 | photoreceptor outer segment degeneration | "retrogressive pathologic change in the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pcdhgtm2Xzw/Pcdhgtm2Xzw,Robo2tm1Rilm/Robo2tm1Rilm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1
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| MP:0008892 | abnormal sperm flagellum | "any strucutral anomaly of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MESH:A05.360.490.890.840] |
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Allelic Composition: Pcdhgtm2Xzw/Pcdhgtm2Xzw,Robo2tm1Rilm/Robo2tm1Rilm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1
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| MP:0009141 | increased prepulse inhibition | "increase in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bbs4tm1b(EUCOMM)Hmgu/Bbs4tm1b(EUCOMM)Hmgu
Genetic Background: B6N(Cg)-Bbs4tm1b(EUCOMM)Hmgu/J
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| MP:0009703 | decreased birth body size | "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pcdhgtm2Xzw/Pcdhgtm2Xzw,Robo2tm1Rilm/Robo2tm1Rilm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1
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| MP:0009836 | abnormal sperm principal piece morphology | "any structural abnormality in the segment of the sperm flagellum where the mitochondrial sheath ends and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs; the principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece" [PMID:14581499] |
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Allelic Composition: Pcdhgtm2Xzw/Pcdhgtm2Xzw,Robo2tm1Rilm/Robo2tm1Rilm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1
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| MP:0009838 | abnormal sperm axoneme morphology | "any structural abnormality of the central core of the sperm flagellum, composed of a ring of 9 outer microtubule doublets surrounding a central pair; inner and outer dynein arms project from each of the outer 9 doublets, and these arms are responsible for generating the motive force of the flagellum; in addition, 9 radial spokes, each of which originates from 1 of the 9 outer microtubular doublet pairs, project inward toward the central pair in a helical fashion" [PMID:14581499] |
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Allelic Composition: Pcdhgtm2Xzw/Pcdhgtm2Xzw,Robo2tm1Rilm/Robo2tm1Rilm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1
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| MP:0011056 | abnormal brain ependyma motile cilium morphology | "any structural anomaly of the tiny, motile hair-like projections from the epithelial cells that line the ventricles in the brain, which beat in concert and to move cerebrospinal fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pcdhgtm2Xzw/Pcdhgtm2Xzw,Robo2tm1Rilm/Robo2tm1Rilm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1
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| MP:0011098 | complete embryonic lethality during organogenesis | "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Bbs7tm1Vcs/Bbs7tm1Vcs,Ift88Tg737Rpw/Ift88Tg737Rpw
Genetic Background: involves: FVB/N
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| MP:0011110 | partial preweaning lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith] |
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Allelic Composition: Pcdhgtm2Xzw/Pcdhgtm2Xzw,Robo2tm1Rilm/Robo2tm1Rilm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1
Allelic Composition: Bbs7tm1b(EUCOMM)Wtsi/Bbs7tm1b(EUCOMM)Wtsi
Genetic Background: B6N(Cg)-Bbs7tm1b(EUCOMM)Wtsi/J
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| MP:0011939 | increased food intake | "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith] |
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Allelic Composition: Pcdhgtm2Xzw/Pcdhgtm2Xzw,Robo2tm1Rilm/Robo2tm1Rilm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1
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| MP:0012468 | decreased striatum area | "reduced size of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [ISBN:0838580343, MGI:csmith] |
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Allelic Composition: Pcdhgtm2Xzw/Pcdhgtm2Xzw,Robo2tm1Rilm/Robo2tm1Rilm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1
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| MP:0012531 | delayed limb development | "late onset of the induction and/or differentiation of the limbs" [MGI:anna] |
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Allelic Composition: Bbs7tm1Vcs/Bbs7tm1Vcs,Ift88Tg737Rpw/Ift88Tg737Rpw
Genetic Background: involves: FVB/N
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| MP:0013202 | abnormal cilium morphology | "any structural anomaly of the specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface; each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole " [GO:0005929] |
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Allelic Composition: Pcdhgtm2Xzw/Pcdhgtm2Xzw,Robo2tm1Rilm/Robo2tm1Rilm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1
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