ENSMUSG00000037366


Mus musculus

Features
Gene ID: ENSMUSG00000037366
  
Biological name :Pafah2
  
Synonyms : Pafah2 / Platelet-activating factor acetylhydrolase 2, cytoplasmic / Q8VDG7
  
Possible biological names infered from orthology : platelet activating factor acetylhydrolase 2 / Q99487
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D3
Gene start: 134396320
Gene end: 134427413
  
Corresponding Affymetrix probe sets: 10508974 (MoGene1.0st)   1448489_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117607
Ensembl peptide - ENSMUSP00000101495
Ensembl peptide - ENSMUSP00000101496
NCBI entrez gene - 100163     See in Manteia.
MGI - MGI:2140321
RefSeq - XM_017319887
RefSeq - NM_001285872
RefSeq - NM_001285874
RefSeq - NM_001285875
RefSeq - NM_001285877
RefSeq - NM_133880
RefSeq - XM_006538455
RefSeq - XM_011250171
RefSeq Peptide - NP_001272801
RefSeq Peptide - NP_001272806
RefSeq Peptide - NP_598641
RefSeq Peptide - NP_001272803
RefSeq Peptide - NP_001272804
swissprot - E9QNW6
swissprot - D3Z3Q4
swissprot - Q8VDG7
Ensembl - ENSMUSG00000037366
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PAFAH2ENSGALG00000021658Gallus gallus
 PAFAH2ENSG00000158006Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pla2g7 / Q60963 / Platelet-activating factor acetylhydrolase / Q13093* / phospholipase A2 group VII*ENSMUSG0000002391337


Protein motifs (from Interpro)
Interpro ID Name
 IPR005065  Platelet-activating factor acetylhydrolase-like
 IPR016715  Platelet-activating factor acetylhydrolase, eucaryote
 IPR029058  Alpha/Beta hydrolase fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Platelet homeostasis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kcnq1ot1tm2Mjh/Kcnq1ot1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Kcnq1ot1tm2Mjh/Kcnq1ot1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0008412 increased cellular sensitivity to oxidative stress "greater incidence of cell death or enhanced production of reactive oxygen species after exposure to a variety of stress conditions including ionizing radiation, exposure to xenobiotics, inflammation, and phagocytosis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kcnq1ot1tm2Mjh/Kcnq1ot1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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