ENSMUSG00000037583


Mus musculus

Features
Gene ID: ENSMUSG00000037583
  
Biological name :Nr0b2
  
Synonyms : Nr0b2 / Nuclear receptor subfamily 0 group B member 2 / Q62227
  
Possible biological names infered from orthology : Q15466
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D2.3
Gene start: 133553376
Gene end: 133556536
  
Corresponding Affymetrix probe sets: 10508887 (MoGene1.0st)   1449854_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000039175
NCBI entrez gene - 23957     See in Manteia.
MGI - MGI:1346344
RefSeq - NM_011850
RefSeq Peptide - NP_035980
swissprot - Q62227
Ensembl - ENSMUSG00000037583
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nr0b2aENSDARG00000044685Danio rerio
 nr0b2bENSDARG00000102756Danio rerio
 NR0B2ENSGALG00000000887Gallus gallus
 NR0B2ENSG00000131910Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nr0b1 / Q61066 / Nuclear receptor subfamily 0 group B member 1 / P51843*ENSMUSG0000002505633


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001723  Nuclear hormone receptor
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007219 Notch signaling pathway IDA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0032024 positive regulation of insulin secretion IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0042974 retinoic acid receptor binding IEA
 molecular_functionGO:0042975 peroxisome proliferator activated receptor binding IEA
 molecular_functionGO:0046965 retinoid X receptor binding IEA
 molecular_functionGO:0046966 thyroid hormone receptor binding IEA


Pathways (from Reactome)
Pathway description
Nuclear Receptor transcription pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nr0b2tm1Mjev/Nr0b2tm1Mjev,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S/SvEvBrd * C57BL/6 * DBA

Allelic Composition: Nr0b2tm1.1Mjev/Nr0b2tm1.1Mjev
Genetic Background: involves: 129S/SvEvBrd * 129S4/SvJae

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Nr0b2tm1.1Mjev/Nr0b2tm1.1Mjev
Genetic Background: involves: 129S/SvEvBrd * 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nr0b2tm1Mjev/Nr0b2tm1Mjev,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S/SvEvBrd * C57BL/6 * DBA

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Icam1tm1Alb/Icam1tm1Alb
Genetic Background: B6.Cg-Icam1tm1Alb

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Foxp3tm2Flv/Y
Genetic Background: involves: C57BL/6

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Nr0b2tm1.1Mjev/Nr0b2tm1.1Mjev
Genetic Background: involves: 129S/SvEvBrd * 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Icam1tm1Alb/Icam1tm1Alb
Genetic Background: B6.Cg-Icam1tm1Alb

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxp3tm2Flv/Y
Genetic Background: involves: C57BL/6

 MP:0002646 increased cholesterol absorption "augmented ability of the body to take in these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Icam1tm1Alb/Icam1tm1Alb
Genetic Background: B6.Cg-Icam1tm1Alb

 MP:0002781 increased circulating testosterone level "greater than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Foxp3tm2Flv/Y
Genetic Background: involves: C57BL/6

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nr0b2tm1Rus/Nr0b2tm1Rus
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003378 early sexual maturation "pubertal changes occur at an earlier than normal age" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Foxp3tm2Flv/Y
Genetic Background: involves: C57BL/6

 MP:0004774 abnormal bile salt level "anomalous concentration of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary sytem as bile salts; these play an important role in the digestion and absorption of fats" [MESH:D04.808.105, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Nr0b2tm1Rus/Nr0b2tm1Rus
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004789 increased bile salt level "increased concentration of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary sytem as bile salts; these play an important role in the digestion and absorption of fats" [MESH:D04.808.105, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxp3tm2Flv/Y
Genetic Background: involves: C57BL/6

 MP:0004884 abnormal testicular physiology "anomaly or loss either the production of male germ cells or the endocrine cells for the production testosterone" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxp3tm2Flv/Y
Genetic Background: involves: C57BL/6

 MP:0004928 increased epididymis weight "increase in the average weight of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxp3tm2Flv/Y
Genetic Background: involves: C57BL/6

 MP:0005146 decreased circulating VLDL cholesterol level "less than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nr0b2tm1.1Mjev/Nr0b2tm1.1Mjev
Genetic Background: involves: 129S/SvEvBrd * 129S4/SvJae

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Nr0b2tm1Mjev/Nr0b2tm1Mjev,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S/SvEvBrd * C57BL/6 * DBA

Allelic Composition: Nr0b2tm1.1Mjev/Nr0b2tm1.1Mjev
Genetic Background: involves: 129S/SvEvBrd * 129S4/SvJae

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Icam1tm1Alb/Icam1tm1Alb
Genetic Background: B6.Cg-Icam1tm1Alb

 MP:0005365 abnormal bile salt homeostasis "anomalous regulation of the steroid salts derived from cholesterol in the liver and which play an important role in the digestion and absorption of fats" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86154]
Show

Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Nr0b2tm1Rus/Nr0b2tm1Rus
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0010180 increased susceptibility to weight loss "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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