ENSMUSG00000037600


Mus musculus

Features
Gene ID: ENSMUSG00000037600
  
Biological name :Kdf1
  
Synonyms : A2A9F4 / Kdf1 / Keratinocyte differentiation factor 1
  
Possible biological names infered from orthology : Q8NAX2
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D2.3
Gene start: 133518963
Gene end: 133530790
  
Corresponding Affymetrix probe sets: 10508883 (MoGene1.0st)   1417797_a_at (Mouse Genome 430 2.0 Array)   1417798_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000048768
Ensembl peptide - ENSMUSP00000122170
Ensembl peptide - ENSMUSP00000119014
Ensembl peptide - ENSMUSP00000113590
Ensembl peptide - ENSMUSP00000101521
NCBI entrez gene - 69073     See in Manteia.
MGI - MGI:1916323
RefSeq - XM_006539151
RefSeq - NM_001083916
RefSeq - NM_133707
RefSeq - XM_006539150
RefSeq Peptide - NP_598468
RefSeq Peptide - NP_001077385
swissprot - A8Y5H9
swissprot - A2A9F3
swissprot - A2A9F2
swissprot - A2A9F4
Ensembl - ENSMUSG00000037600
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kdf1aENSDARG00000079834Danio rerio
 kdf1bENSDARG00000101878Danio rerio
 KDF1ENSGALG00000000902Gallus gallus
 KDF1ENSG00000175707Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR028003  Keratinocyte differentiation factor 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003334 keratinocyte development IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0010482 regulation of epidermal cell division IMP
 biological_processGO:0010839 negative regulation of keratinocyte proliferation IMP
 biological_processGO:0016331 morphogenesis of embryonic epithelium IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0045606 positive regulation of epidermal cell differentiation IMP
 biological_processGO:0048589 developmental growth IMP
 biological_processGO:0060887 limb epidermis development IMP
 biological_processGO:0061436 establishment of skin barrier IMP
 biological_processGO:2000647 negative regulation of stem cell proliferation IMP
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005938 cell cortex IDA
 cellular_componentGO:0030054 cell junction ISO
 cellular_componentGO:0031252 cell leading edge IDA
 cellular_componentGO:0072686 mitotic spindle ISO
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Kdf1shd/Kdf1+,SfnEr/Sfn+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Kdf1shd/Kdf1shd
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Kdf1shd/Kdf1shd
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0000468 abnormal esophageal epithelium morphology "malformation of the epithelial layer of the esophagus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Kdf1shd/Kdf1shd
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
Show

Allelic Composition: Kdf1shd/Kdf1shd
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
Show

Allelic Composition: Kdf1shd/Kdf1shd
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
Show

Allelic Composition: Kdf1shd/Kdf1shd
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0000764 abnormal tongue epithelium morphology "malformation of the epithelial layer of the tongue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Kdf1shd/Kdf1shd
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0001198 tight skin "skin has a taut, stretched appearance" [J:65038]
Show

Allelic Composition: Kdf1shd/Kdf1shd
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
Show

Allelic Composition: Kdf1shd/Kdf1+,SfnEr/Sfn+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Kdf1shd/Kdf1shd
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0001240 abnormal cornified layer morphology "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kdf1shd/Kdf1+,SfnEr/Sfn+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0001241 absent cornified layer "missing the outer layer of the epidermis, composed of several layers of keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kdf1shd/Kdf1shd
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kdf1shd/Kdf1shd
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0002160 abnormal reproductive system morphology "structural or developmental anomaly of any of the tissues involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kdf1shd/Kdf1shd
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0002233 abnormal nose morphology "any structural anomaly of the organ that is specialized for smell and is part of the respiratory system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Kdf1shd/Kdf1shd
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0002656 abnormal keratinocyte differentiation "developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mus81tm1Chmg/Mus81tm1Chmg,Slx1btm1.1Jrou/Slx1btm1.1Jrou
Genetic Background: involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6

Allelic Composition: Kdf1shd/Kdf1tm1a(EUCOMM)Wtsi
Genetic Background: involves: C3HeB/FeJ * C57BL/6J * C57BL/6N

Allelic Composition: Kdf1shd/Kdf1shd
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
Show

Allelic Composition: Mus81tm1Chmg/Mus81tm1Chmg,Slx1btm1.1Jrou/Slx1btm1.1Jrou
Genetic Background: involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6

Allelic Composition: Kdf1shd/Kdf1tm1a(EUCOMM)Wtsi
Genetic Background: involves: C3HeB/FeJ * C57BL/6J * C57BL/6N

Allelic Composition: Kdf1shd/Kdf1+,SfnEr/Sfn+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Kdf1shd/Kdf1shd
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0003938 abnormal ear development "developmental anomaly of any of the structures involved in the ear or vestibular system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kdf1shd/Kdf1shd
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0009576 oral atresia "congenital blockage, fusion, or absence of the normal opening of the oral cavity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kdf1shd/Kdf1+,SfnEr/Sfn+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Kdf1shd/Kdf1shd
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0009583 increased keratinocyte proliferation "increase in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kdf1shd/Kdf1shd
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0009884 palatal shelf fusion with tongue or mandible "palatal shelves do not elevate during development and instead fuse with tongue tissues or with the mandible tissues" [PMID:16680722]
Show

Allelic Composition: Kdf1shd/Kdf1shd
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Kdf1shd/Kdf1shd
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Kdf1shd/Kdf1+,SfnEr/Sfn+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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