ENSMUSG00000037771


Mus musculus

Features
Gene ID: ENSMUSG00000037771
  
Biological name :Slc32a1
  
Synonyms : O35633 / Slc32a1 / solute carrier family 32 (GABA vesicular transporter), member 1
  
Possible biological names infered from orthology : Q9H598 / solute carrier family 32 member 1
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H1
Gene start: 158610767
Gene end: 158615748
  
Corresponding Affymetrix probe sets: 10478124 (MoGene1.0st)   1422756_at (Mouse Genome 430 2.0 Array)   1447573_at (Mouse Genome 430 2.0 Array)   1447574_s_at (Mouse Genome 430 2.0 Array)   1456457_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000036299
NCBI entrez gene - 22348     See in Manteia.
MGI - MGI:1194488
RefSeq - NM_009508
RefSeq Peptide - NP_033534
swissprot - O35633
swissprot - Q49S98
Ensembl - ENSMUSG00000037771
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc32a1ENSDARG00000059775Danio rerio
 SLC32A1ENSGALG00000038919Gallus gallus
 Q9H598ENSG00000101438Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR013057  Amino acid transporter, transmembrane domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006836 neurotransmitter transport IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0015812 gamma-aminobutyric acid transport IEA
 biological_processGO:0015816 glycine transport IDA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0098700 neurotransmitter loading into synaptic vesicle IEA
 cellular_componentGO:0005887 integral component of plasma membrane IC
 cellular_componentGO:0008021 synaptic vesicle IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030285 integral component of synaptic vesicle membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043229 intracellular organelle IEA
 cellular_componentGO:0044292 dendrite terminus IDA
 cellular_componentGO:0044306 neuron projection terminus IEA
 cellular_componentGO:0044316 cone cell pedicle IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048786 presynaptic active zone IDA
 cellular_componentGO:0051286 cell tip IDA
 cellular_componentGO:0060077 inhibitory synapse IEA
 molecular_functionGO:0015187 glycine transmembrane transporter activity IDA
 molecular_functionGO:0015495 gamma-aminobutyric acid:proton symporter activity IDA


Pathways (from Reactome)
Pathway description
Transport of inorganic cations/anions and amino acids/oligopeptides
GABA synthesis, release, reuptake and degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000013 abnormal fat distribution "alterations in the normal placement and amount of body fat" [J:57315]
Show

Allelic Composition: Xirp1tm1Dofr/Xirp1tm1Dofr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Gad1tm1Tama/Gad1tm1Tama,Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0000188 abnormal circulating glucose level "anomalous concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Slc32a1tm2(cre)Lowl/Slc32a1+
Genetic Background: involves: 129S6/SvEvTac

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Slc32a1tm2(cre)Lowl/Slc32a1+
Genetic Background: involves: 129S6/SvEvTac

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl,Slc32a1tm2(cre)Lowl/Slc32a1+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Agrptm1(cre)Lowl/Agrp+,Slc32a1tm1Lowl/Slc32a1tm1Lowl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Agrptm1(cre)Lowl/Agrp+,Slc32a1tm1Lowl/Slc32a1tm1Lowl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001404 no spontaneous movement "failure to make any change in position or posture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Slc32a1tm2(cre)Lowl/Slc32a1+
Genetic Background: involves: 129S6/SvEvTac

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
Show

Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Slc32a1tm1.1Bgc/Slc32a1tm1.1Bgc
Genetic Background: involves: 129X1/SvJ

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Gad1tm1Tama/Gad1tm1Tama,Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Slc32a1tm1.1Bgc/Slc32a1tm1.1Bgc
Genetic Background: involves: 129X1/SvJ

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Slc32a1tm2(cre)Lowl/Slc32a1+
Genetic Background: involves: 129S6/SvEvTac

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc17a6tm2(cre)Lowl/Slc17a6+
Genetic Background: involves: 129S6/SvEvTac

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gad1tm1Tama/Gad1tm1Tama,Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Slc32a1tm2(cre)Lowl/Slc32a1+
Genetic Background: involves: 129S6/SvEvTac

 MP:0002911 abnormal inhibitory postsynaptic potential "defect in the membrane potential detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Gad1tm1Tama/Gad1tm1Tama,Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Agrptm1(cre)Lowl/Agrp+,Slc32a1tm1Lowl/Slc32a1tm1Lowl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Slc32a1tm2(cre)Lowl/Slc32a1+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Slc32a1tm2(cre)Lowl/Slc32a1+,Tg(Pomc1-hrGFP)1Lowl/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0003052 omphalocele "protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Slc32a1tm1Yyan/Slc32a1tm1Yyan
Genetic Background: Not Specified

 MP:0003477 abnormal nerve fiber response "anomaly in the electrophysiological recordings from a single or several nerve fiber(s)" [Nmice:Neuromice Consortium Submission]
Show

Allelic Composition: Slc32a1tm1Yyan/Slc32a1tm1Yyan
Genetic Background: Not Specified

 MP:0003990 decreased neurotransmitter release "reduced secretion of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0004143 hypertonia "increased muscle tone" [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Agrptm1(cre)Lowl/Agrp+,Slc32a1tm1Lowl/Slc32a1tm1Lowl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Agrptm1(cre)Lowl/Agrp+,Slc32a1tm1Lowl/Slc32a1tm1Lowl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Agrptm1(cre)Lowl/Agrp+,Slc32a1tm1Lowl/Slc32a1tm1Lowl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0009886 failure of palatal shelf elevation "the palatal shelves fail to move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue" [PMID:16680722]
Show

Allelic Composition: Slc32a1tm1.1Bgc/Slc32a1tm1.1Bgc
Genetic Background: involves: 129X1/SvJ

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
Show

Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Slc32a1tm1.1Bgc/Slc32a1tm1.1Bgc
Genetic Background: involves: 129X1/SvJ

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Slc32a1tm2(cre)Lowl/Slc32a1+
Genetic Background: involves: 129S6/SvEvTac

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agrptm1(cre)Lowl/Agrp+,Slc32a1tm1Lowl/Slc32a1tm1Lowl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0010146 umbilical hernia "an outward bulging (protrusion) of the abdominal lining or part of the abdominal organ(s) through the area around the umbilicus; occurs when the muscle through which blood vessels pass to feed the developing fetus fails to completely close" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", PMID:20333300]
Show

Allelic Composition: Slc32a1tm1.1Bgc/Slc32a1tm1.1Bgc
Genetic Background: involves: 129X1/SvJ

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agrptm1(cre)Lowl/Agrp+,Slc32a1tm1Lowl/Slc32a1tm1Lowl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0010819 primary atelectasis "nonexpansion of the lungs after birth, seen in stillborn organisms and in live born animals that do not establish respiration" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Slc32a1tm1Yyan/Slc32a1tm1Yyan
Genetic Background: Not Specified

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Slc32a1tm1Yyan/Slc32a1tm1Yyan
Genetic Background: Not Specified

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Slc32a1tm1.1Bgc/Slc32a1tm1.1Bgc
Genetic Background: involves: 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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